Addendum to Nitrobenzene [BAT Value Documentation, 2017]

Hartwig, A.; Arand, Michael

doi:10.1002/3527600418.bb9895e2318

Cited by 1 publication

(2 citation statements)

References 4 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the process of exposure reconstruction also has inherent limitations. However, although the applied PBPK model is not yet fully calibrated, it compared relatively well with the published aggregated data used earlier to, for example, set BEI and BAT values for TDI [ 29 , 30 ]. For HDI, a correlation formula by Maitre et al [ 17 ] was used.…”

Section: Discussionmentioning

confidence: 92%

“…These corresponded to exposure to threshold limit values (TLVs) of 0.001 ppm and 0.005 ppm (0.007 and 0.034 mg/m 3 for TDI and HDI, respectively) when sampled at the end of the shift. Similarly, the Deutsche Forschungsgemeinschaft (DFG) has given a biological tolerance (BAT) value of 15 µg/g creatinine, measured as urinary HDA, for HDI and a BAT value of 5 µg/g creatinine, measured as the sum of urinary 2,4- and 2,6-TDA, for TDI [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Occupational Exposure and Health Impact Assessment of Diisocyanates in Finland

Huuskonen

Porras

Scholten

et al. 2023

Toxics

View full text Add to dashboard Cite

Diisocyanates are a group of chemicals widely used in different industrial applications. The critical health effects related to diisocyanate exposure are isocyanate sensitisation, occupational asthma and bronchial hyperresponsiveness (BHR). Industrial air measurements and human biomonitoring (HBM) samples were gathered in specific occupational sectors to examine MDI, TDI, HDI and IPDI and the respective metabolites from Finnish screening studies. HBM data can give a more accurate picture of diisocyanate exposure, especially if workers have been exposed dermally or used respiratory protection. The HBM data were used for conducting a health impact assessment (HIA) in specific Finnish occupational sectors. For this purpose, exposure reconstruction was performed on the basis of HBM measurements of TDI and MDI exposures using a PBPK model, and a correlation equation was made for HDI exposure. Subsequently, the exposure estimates were compared to a previously published dose–response curve for excess BHR risk. The results showed that the mean and median diisocyanate exposure levels and HBM concentrations were low for all diisocyanates. In HIA, the excess risk of BHR from MDI exposure over a working life period was highest in the construction and motor and vehicle industries and repair sectors, resulting in estimated excess risks of BHR of 2.0% and 2.6%, and 113 and 244 extra BHR cases in Finland, respectively. Occupational exposure to diisocyanates must be monitored because a clear threshold for DI sensitisation cannot be established.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%