Added value of susceptibility-weighted imaging to diffusion-weighted imaging in the characterization of parotid gland tumors

Jiang, Jia-Suo; Zhu, Liu-Ning; Chen, Wei; Chen, Lu; Su, Guo‐Yi; Xu, Xiao‐Quan

doi:10.1007/s00405-020-05985-x

Cited by 9 publications

(14 citation statements)

References 23 publications

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“…2. The risk associated with patient selection was considered unclear in 11 studies due to uncertainty about whether consecutive patients had been enrolled [6,[19][20][21][22][23][24][25][26][27][28]. The risk of bias with respect to the index test was unclear in nine studies due to unclear information about blinding protocols [6,[19][20][21][22]24,26,29,30].…”

Section: Methodological Quality Assessmentmentioning

confidence: 99%

“…The risk of bias with respect to the index test was unclear in nine studies due to unclear information about blinding protocols [6,[19][20][21][22]24,26,29,30]. The risk of bias with respect to the reference standard was unclear in all studies [6,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33], as it could not be determined whether the study references had been interpreted without knowledge of the index test results. The risk of bias with respect to flow and timing was rated high in four studies with multiple subsets [19,25,29,34], and one subset was selected from each to prevent oversampling.…”

Section: Methodological Quality Assessmentmentioning

confidence: 99%

“…The risk of bias with respect to flow and timing was rated high in four studies with multiple subsets [19,25,29,34], and one subset was selected from each to prevent oversampling. The risk of bias with respect to flow and timing was rated unclear in nine studies [6,[20][21][22][23][24]26,28,32] because either the same reference standards were not used or the interval between the index test and reference standard was not reported. There were no obvious applicable concerns.…”

Section: Methodological Quality Assessmentmentioning

confidence: 99%

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Performance of diffusion-weighted imaging for the diagnosis of parotid gland malignancies: A meta-analysis

Chen

Liu

Tang

et al. 2021

European Journal of Radiology

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This study aimed to assess the diagnostic performance of diffusion-weighted imaging (DWI) for parotid gland malignancies. Methods: Four databases (PubMed, the Cochrane Library, Embase, and Web of Science) were searched systematically and retrospectively by two researchers until May 18, 2020. The methodological quality of the studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. A bivariate random effects model was used to pool the sensitivity and specificity data for the apparent diffusion coefficient (ADC). Summary receiver operating characteristic curve was constructed, and the area under the curve (AUC) was calculated. The positive (LR+) and negative likelihood ratios (LR-) were also calculated. Subgroup and meta-regression analyses were performed to evaluate heterogeneity within studies. Results: Sixteen studies involving 1004 patients were included. The pooled sensitivity, specificity, and AUC for the ADC to distinguish malignant from begin parotid lesions were 89 %, 76 %, and 0.91, respectively. The LR + was 3.7 and LR-was 0.15, respectively. Subgroup analyses revealed that the applied cut-off b values and study size were sources of heterogeneity for the ADC. There were publication bias concerns. Conclusions: Our meta-analysis suggests that the ADC value provides excellent sensitivity and moderate specificity for the diagnosis of malignant lesions in the parotid gland. However, substantial heterogeneity was found. Therefore, additional larger, prospective studies in combination with standard techniques focusing on parotid tumors should be conducted to determine the true performance of DWI for the differential diagnosis of parotid lesions.

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Section: Methodological Quality Assessmentmentioning

confidence: 99%

Section: Methodological Quality Assessmentmentioning

confidence: 99%

Section: Methodological Quality Assessmentmentioning

confidence: 99%

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Performance of diffusion-weighted imaging for the diagnosis of parotid gland malignancies: A meta-analysis

Chen

Liu

Tang

et al. 2021

European Journal of Radiology

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“…Newer MRI sequences bring additional values and can improve diagnostic accuracy, however do not allow for definite detection of tumor malignancy and are time consuming. High diffusion restriction on diffusion-weighted-imaging (DWI) corresponding with its derived low apparent diffusion coefficient (ADC) values and high intratumoral susceptibility signal intensity (ITSS) on susceptibility-weighted imaging (SWI), the latter an indirect indicator of angiogenesis, may indicate malignancy [54]. However, Warthin tumors may have confusing features, showing even higher diffusion restriction than malignant tumors and similar ITSS [54].…”

Section: Contrast-enhanced and Nuclear Medicine Techniquesmentioning

confidence: 99%

WFUMB position paper. Incidental findings of the salivary glands

Białek¹,

Lim

Dong

et al. 2021

Med Ultrason

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A salivary incidentaloma (SI) stands for any focal salivary lesion, independent of size, discovered by any imaging method including ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), multimodal positron emis-sion tomography (PET) combined with CT or MRI, or X-ray imaging, performed for another reason, in the absence of known salivary glands’ disease. The article presents a detailed analysis of salivary gland diseases with the emphasis on neoplasms. It describes frequency of SIs found on imaging, their prevalence, epidemiology and clinical significance. The probability of malignancy or malignant transformation of a SI, its imaging features, recommended treatment, management and follow-up, as well as ethical issues, psychological burden, informed decision making, economical consequences and costs are discussed. The general prevalence of SIs is low, but is dramatically increasing over time, and may rise significantly in selected groups of oncologic patients. SIs most frequently turn out to be benign primary neoplasms or pseudotumors, including intraparenchymal lymph nodes. SIs detected by other imaging methods should be subsequently assessed with US. Solid SIs demand ultrasound guided fine-needle aspiration cytology (US-FNAC). Neoplasms should undergo surgery. Post-operative US follow-up is man-datory for malignant tumors and recommended for benign neoplasms.

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“…Diffusion weighted imaging (DWI) is a widely-used technique for evaluating the rate of microscopic water diffusion in tissues. Its derived apparent diffusion coefficient (ADC) has been accepted as an important diagnostic marker for characterizing parotid gland tumors [1][2][3][4][5][6]. In clinical practice, single-shot echo-planar imaging (SS-EPI) is commonly used for DWI scan.…”

Section: Introductionmentioning

confidence: 99%

Feasibility study of using simultaneous multi-slice RESOLVE diffusion weighted imaging to assess parotid gland tumors: comparison with conventional RESOLVE diffusion weighted imaging

Jiang

Zhu

et al. 2020

BMC Med Imaging

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Background: To evaluate the feasibility of using simultaneous multi-slice (SMS) readout segmentation of long variable echo-trains (RESOLVE) diffusion-weighted imaging (DWI) to assess parotid gland tumors, compared with conventional RESOLVE DWI. Methods: From September 2018 to December 2018, 20 consecutive patients with parotid tumors who underwent MRI scan for pre-surgery evaluation were enrolled. SMS-RESOLVE DWI and conventional RESOLVE DWI were scanned with matched imaging parameters, respectively. The scan time of two DWI sequences was recorded. Qualitative (anatomical structure differentiation, lesion display, artifact, and overall image quality) and quantitative (apparent diffusion coefficient, ADC; ratio of signal-to-noise ratio, SNR ratio; ratio of contrast-to-noise ratio, CNR ratio) assessments of image quality were performed, and compared between SMS-RESOLVE DWI and conventional RESOLVE DWI by using Paired t-test. Two-sided P value less than 0.05 indicated significant difference. Results: The scan time was 3 min and 41 s for SMS-RESOLVE DWI, and 5 min and 46 s for conventional RESOLVE DWI. SMS-RESOLVE DWI produced similar qualitative image quality with RESOLVE DWI (anatomical structure differentiation, P = 0.164; lesion display, P = 0.193; artifact, P = 0.330; overall image quality, P = 0.083). Meanwhile, there were no significant difference on ADC Lesion (P = 0.298), ADC Masseter (P = 0.122), SNR ratio (P = 0.584) and CNR ratio (P = 0.217) between two DWI sequences. Conclusion: Compared with conventional RESOLVE DWI, SMS-RESOLVE DWI could provide comparable image quality using markedly reduced scan time. SMS could increase the clinical usability of RESOLVE technique for DWI of parotid gland.

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Added value of susceptibility-weighted imaging to diffusion-weighted imaging in the characterization of parotid gland tumors

Cited by 9 publications

References 23 publications

Performance of diffusion-weighted imaging for the diagnosis of parotid gland malignancies: A meta-analysis

Performance of diffusion-weighted imaging for the diagnosis of parotid gland malignancies: A meta-analysis

WFUMB position paper. Incidental findings of the salivary glands

Feasibility study of using simultaneous multi-slice RESOLVE diffusion weighted imaging to assess parotid gland tumors: comparison with conventional RESOLVE diffusion weighted imaging

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