Added predictive value of 18F-FDG PET/CT for pediatric rhabdomyosarcoma

El‐Kholy, Esraa; Nadi, Enas El; Hafez, Hanafy; Ahmed, S.N.; Younes, Alaa; El-Kenanii, Naglaa; Khalid, Elham

doi:10.1097/mnm.0000000000001040

Cited by 16 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, after adjusting on confounding factors in the multivariate analysis, the risks of death and recurrence were approximately 2.6 (p = 0.009) and 2.7 (p = 0.006) times higher for an MTV � 200 cm 3 . Although patient selection relied on a PET scan being performed at diagnosis, our population was representative of the clinical reality, especially for the proportion of boys/girls and the distribution in each risk group [26,38] contrary to previous published PET studies [11,14,39]. The age distribution is as previously described with a bimodal age peaks in childhood [40].…”

Section: Discussionmentioning

confidence: 98%

“…Apart from detecting intrathoracic lesions where chest CT remains essential, F-18 FDG PET-CT (PET) has been shown to be superior to CT for the initial staging of RMS, mainly on account of its ability to detect nodal involvement and metastatic disease [9]. Recent studies, albeit retrospective and with a limited number of patients, have reported equivocal results about the prognostic significance of metabolic tumour activity measured via standardized uptake value (SUV) [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

PET metabolic tumor volume as a new prognostic factor in childhood rhabdomyosarcoma

et al. 2022

View full text Add to dashboard Cite

Purpose Childhood RMS is a rare malignant disease in which evaluation of tumour spread at diagnosis is essential for therapeutic management. F-18 FDG-PET imaging is currently used for initial RMS disease staging. Materials and methods This multicentre retrospective study in six French university hospitals was designed to analyse the prognostic accuracy of MTV at diagnosis for patients with RMS between 1 January 2007 and 31 October 2017, for overall (OS) and progression-free survival (PFS). MTV was defined as the sum of the primitive tumour and the largest metastasis, where relevant, with a 40% threshold of the primary tumour SUVmax. Additional aims were to define the prognostic value of SUVmax, SUVpeak, and bone lysis at diagnosis. Results Participants were 101 patients with a median age of 7.4 years (IQR [4.0-12.5], 62 boys), with localized disease (35 cases), regional nodal spread (43 cases), or distant metastases (23). 44 patients had alveolar subtypes. In a univariate analysis, a MTV greater than 200 cm3 was associated with OS (HR = 3.47 [1.79;6.74], p<0.001) and PFS (HR = 3.03 [1.51;6.07], p = 0.002). SUVmax, SUVpeak, and bone lysis also influenced OS (respectively p = 0.005, p = 0.004 and p = 0.007) and PFS (p = 0.029, p = 0.019 and p = 0.015). In a multivariate analysis, a MTV greater than 200 cm3 was associated with OS (HR = 2.642 [1.272;5.486], p = 0.009) and PFS (HR = 2.707 [1.322;5.547], p = 0.006) after adjustment for confounding factors, including SUVmax, SUVpeak, and bone lysis. Conclusion A metabolic tumor volume greater than 200 cm3, SUVmax, SUVpeak, and bone lysis in the pre-treatment assessment were unfavourable for outcome.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

PET metabolic tumor volume as a new prognostic factor in childhood rhabdomyosarcoma

et al. 2022

View full text Add to dashboard Cite

show abstract

“…There are no references for the performance of type I and type II PPB on 18 F-FDG PET/CT, so we cannot be sure whether PPB tumor cells take up 18 F-FDG or whether the high 18 F-FDG uptake of type II PPB we report is caused by PPB cells alone, by partially differentiated rhabdomyosarcoma tissue alone, or by them together. It has been shown that rhabdomyosarcoma has a high glucose metabolism (average SUVmax of 7.2) and that the higher the degree of glucose uptake, the more aggressive the tumor is and the more likely it is to develop distant metastases (15,16). Furthermore, higher glucose metabolism in rhabdomyosarcoma tends to predict a worse prognosis (17).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Pleuropulmonary Blastoma in a 2.5-Year-Old Boy: 18F-FDG PET/CT Findings

Ruan

Sun

2021

Front. Nucl. Med.

View full text Add to dashboard Cite

Pleuropulmonary blastoma (PPB) is a rare invasive primary malignancy in the thoracic cavity that occurs mainly in infants and children. It is often misdiagnosed and not treated correctly and promptly due to the lack of specificity of clinical symptoms and conventional imaging presentations. We report a 2.5-year-old boy who underwent X-ray chest radiography, chest CT, and 18F-FDG PET/CT. PET/CT images demonstrated a sizeable cystic-solid mass with heterogeneous increased glucose metabolism in the left thoracic cavity. The diagnosis of PPB (type II) was finally confirmed by a CT-guided puncture biopsy of the active tumor tissue. This case highlights the critical role of 18F-FDG PET/CT in the diagnosis of PPB in children.

show abstract

“…SUV max of primary sites of RMS was quite different in previous studies, in which it ranged from 0 to 32 ( 9 , 11 , 17 – 22 , 24 ). High SUV max was more prevalent among patients with less favorable clinical and pathological features including unfavorable primary site, alveolar pathology, presence of regional or distant metastasis, and high-risk group, relating to worse prognosis ( 23 ). However, there exists criticism in using SUV to evaluate therapy response, since it is calculated only from one voxel of the ROI.…”

Section: Discussionmentioning

confidence: 99%

Utility of [18F] Fluoro-Deoxyglucose Positron Emission Tomography/Computed Tomography for Staging and Therapy Response Evaluation in Pediatric Rhabdomyosarcoma: A Case Series and Literature Review

Liu

Zhao

et al. 2020

Front. Med.

View full text Add to dashboard Cite

Background: The role of [ 18 F] fluoro-deoxyglucose [[ 18 F] FDG] positron emission tomography (PET)/computed tomography (CT) in pediatric rhabdomyosarcoma (RMS) is not well-established. This manuscript explores the role of staging and therapy response evaluation of PET/CT in a series of patients with RMS. Methods: Thirteen consecutive patients with pathologically proven RMS underwent baseline PET/CT scan and a second PET/CT for evaluation of therapy response. Maximum standardized uptake value (SUV max), mean standardized uptake value (SUV mean), highest standardized uptake peak value (SUV peak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were obtained from baseline PET/CT and were used as potential predictors for evaluation of metabolic treatment response. Results: On baseline PET/CT, most RMSs are located in the pelvic cavity, and upper arms ranked second. The primary lesions were large and showed invasion to the surrounding tissues. Lymph node metastases were seen in eight patients, and eight patients showed distant metastasis to the lung, liver, and bone. The median SUV max , SUV mean , and SUV peak of primary sites were 7.1, 4.0, and 5.9, respectively. The median MTV and TLG were 196.6 cm 3 and 780.2, respectively. After therapy, six patients received complete metabolic response (CMR) and non-CMR occurred in seven patients on the second PET/CT. SUV max , SUV peak , MTV, and TLG in patients with CMR were significantly lower than those in patients with non-CMR. Conclusions: Primary sites and metastatic lesions of RMS demonstrate increased glycolytic activity, which may allow them to be imaged using [ 18 F] FDG PET/CT. Metabolic parameters derived from the baseline PET/CT have potential value for predicting CMR to therapy in pediatric RMS.

show abstract

Added predictive value of 18F-FDG PET/CT for pediatric rhabdomyosarcoma

Cited by 16 publications

References 9 publications

PET metabolic tumor volume as a new prognostic factor in childhood rhabdomyosarcoma

PET metabolic tumor volume as a new prognostic factor in childhood rhabdomyosarcoma

Case Report: Pleuropulmonary Blastoma in a 2.5-Year-Old Boy: 18F-FDG PET/CT Findings

Utility of [18F] Fluoro-Deoxyglucose Positron Emission Tomography/Computed Tomography for Staging and Therapy Response Evaluation in Pediatric Rhabdomyosarcoma: A Case Series and Literature Review

Contact Info

Product

Resources

About