Add-on rTMS for the acute treatment of depressive symptoms is probably more effective in adolescents than in adults: Evidence from real-world clinical practice

Zhang, Tianhong; Zhu, Jun‐Juan; Xu, Li-Hua; Tang, Xiaochen; Cui, Huiru; Wei, Yanyan; Wang, Yan; Hu, Qiang; Qian, Zhenying; Liu, Xiaohua; Tang, Yingying; Li, Chunbo; Wang, Jijun

doi:10.1016/j.brs.2018.09.007

Cited by 42 publications

(50 citation statements)

References 24 publications

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“…Additionally, to the best of our knowledge, this is the largest “real-world” TMS study. As known, this type of studies allow the inclusion of a considerable number of subjects with a wide range of demographic features, thus realistically mimicking real-life practice settings (Zhang et al, 2019). Nonetheless, several limitations must also be acknowledged.…”

Section: Discussionmentioning

confidence: 99%

Age, Height, and Sex on Motor Evoked Potentials: Translational Data From a Large Italian Cohort in a Clinical Environment

Cantone¹,

Lanza

Vinciguerra

et al. 2019

Front. Hum. Neurosci.

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Introduction Motor evoked potentials (MEPs) to transcranial magnetic stimulation (TMS) are known to be susceptible to several sources of variability. However, conflicting evidences on individual characteristics in relatively small sample sizes have been reported. We investigated the effect of age, height, and sex on MEPs of the motor cortex and spinal roots in a large cohort. Methods A total of 587 subjects clinically and neuroradiologically intact were included. MEPs were recorded during mild tonic contraction through a circular coil applied over the “hot spot” of the first dorsal interosseous and tibialis anterior muscles (TAs), bilaterally. Central motor conduction time (CMCT) was estimated as the difference between MEP cortical latency and the peripheral motor conduction time (PMCT) by cervical or lumbar magnetic stimulation. Peak-to-peak MEP amplitude to cortical stimulation and right-to-left difference of each parameter were also measured. Results After Bonferroni correction, general linear (multiple) regression analysis showed that both MEP cortical latency and PMCT at four limbs positively correlated with age and height. At lower limbs, an independent effect of sex on the same measures was also observed (with females showing smaller values than males). CMCT correlated with both age (negatively) and height (positively) when analyzed by a single regression; however, with a multiple regression analysis this significance disappeared, due to the correction for the multicollinearity within the dataset. Conclusion Physical individual features need to be considered for a more accurate and meaningful MEPs interpretation. Both in clinical practice and in research setting, patients and controls should be matched for age, height, and sex.

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Section: Discussionmentioning

confidence: 99%

Age, Height, and Sex on Motor Evoked Potentials: Translational Data From a Large Italian Cohort in a Clinical Environment

Cantone¹,

Lanza

Vinciguerra

et al. 2019

Front. Hum. Neurosci.

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“…Tables 1 and 2 summarized the characteristics of the studies. The studies include open-label trials [27][28][29][30][31][32], case reports [33][34][35][36][37], case series [38][39][40][41], naturalistic studies [42], and randomized sham-controlled trial [43].…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…The majority of the studies are from the USA [28][29][30][31][33][34][35]40,43]. The rest of the studies were from China [37,38,42], Israel [32], Finland [36], Canada [27,39], Australia [41], and across multiple nations [44]. The lowest age of the recipient of rTMS was ten [40,42,43], but most of the patients were above 12.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

The Safety and Efficacy of Repetitive Transcranial Magnetic Stimulation in the Treatment of Major Depression Among Children and Adolescents: A Systematic Review

Majumder¹,

Balan²,

Gupta³

et al. 2021

Cureus

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Major depression is a chronic debilitating condition affecting people of all ages and is rising over the past decade. Major depression among children and adolescents is often resistant to traditional treatments, thus necessitating the exploration of novel strategies. Repetitive transcranial magnetic stimulation (rTMS) is gaining increasing attention as a useful tool in treating various conditions and has received the US Food and Drug Administration (FDA) approval to treat depression and obsessive-compulsive disorder among adults. Favorable outcomes among adults generated interest in using it among children. Until recently, the existing literature lacked randomized sham-controlled trials on this topic among children and adolescents. The newest additions in the literature necessitated another in-depth look at the data to explore the safety and efficacy of rTMS in the context of depression among children and adolescents. We searched the Medline and Cochrane databases and included 18 articles for our systematic review. Our systematic review indicates level 1 evidence that rTMS is safe but failed to show its superiority to placebo as a stand-alone treatment for resistant depression among children and adolescents. However, there is level 2 evidence favoring add-on rTMS to treat major depression among children and adolescents. The study subjects appear to tolerate the rTMS treatment well with some minor and mostly self-limited side effects. Risks of treatment-emergent hypomanic symptoms and seizure appear to be very low. There is no evidence of worsening of suicidal ideation or cognitive decline during rTMS treatment.

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“…Another study on data pooled from 3 protocols with 30‐session courses of open‐label rTMS for adolescents with TRD ( N = 19) reported that rTMS mitigated suicidal ideation in adolescents . A naturalistic study aimed to investigate the efficacy and clinical outcome of add‐on rTMS (at least 10 sessions of 10‐Hz HFL) in a sample of adolescents compared with adult patients (42 adolescents and 75 adults) . The authors reported that both groups showed significant improvements, with response and remission rates higher among adolescents in comparison with adults.…”

Section: Special Populationsmentioning

confidence: 99%

An Update on Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder

Trevizol

Blumberger

2019

Clin Pharma and Therapeutics

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Repetitive transcranial magnetic stimulation (rTMS) has emerged as an evidenced‐based treatment for major depression that does not respond to standard first‐line therapies. The majority of data support the use of high‐frequency (10 Hz) treatment delivered to the left dorsolateral prefrontal cortex. Intermittent theta burst stimulation is a new emerging treatment that reduces the time required to deliver treatment and can increase capacity and access to this treatment. This review will comprehensively cover recent advancements in the field of rTMS for depression, including stimulation parameters and targets aimed at enhancing outcomes. In addition, efforts to use modern neuroscience tools to personalize this treatment and optimize outcomes will be reviewed.

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Add-on rTMS for the acute treatment of depressive symptoms is probably more effective in adolescents than in adults: Evidence from real-world clinical practice

Cited by 42 publications

References 24 publications

Age, Height, and Sex on Motor Evoked Potentials: Translational Data From a Large Italian Cohort in a Clinical Environment

Age, Height, and Sex on Motor Evoked Potentials: Translational Data From a Large Italian Cohort in a Clinical Environment

The Safety and Efficacy of Repetitive Transcranial Magnetic Stimulation in the Treatment of Major Depression Among Children and Adolescents: A Systematic Review

An Update on Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder

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