Add‐on probiotics in patients with persistent allergic rhinitis: A randomized crossover clinical trial

Jalali, Mir Mohammad; Soleimani, Robabeh; Foumani, Ali Alavi; Khosravi, Hooman Ganjeh

doi:10.1002/lary.27858

Cited by 30 publications

(19 citation statements)

References 38 publications

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“…thermophilus ) with intranasal budesonide or intranasal budesonide with placebo for 8 weeks. The addition of probiotics significantly improved quality of life in persistent rhinitis patients [ 135 ]. Another research group evaluated the effect of L. rhamnosus GG and vitamin D supplementation on the effectiveness of grass-specific sublingual immunotherapy (SLIT) in children.…”

Section: Results: Evidence Of Efficacy Of Probioticsmentioning

confidence: 99%

Probiotics in Pediatrics. A Review and Practical Guide

Depoorter

Vandenplas

2021

Nutrients

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The potential benefit of the administration of probiotics in children has been studied in many settings globally. Probiotics products contain viable micro-organisms that confer a health benefit on the host. Beneficial effects of selected probiotic strains for the management or prevention of selected pediatric conditions have been demonstrated. The purpose of this paper is to provide an overview of current available evidence on the efficacy of specific probiotics in selected conditions to guide pediatricians in decision-making on the therapeutic or prophylactic use of probiotic strains in children. Evidence to support the use of certain probiotics in selected pediatric conditions is often available. In addition, the administration of probiotics is associated with a low risk of adverse events and is generally well tolerated. The best documented efficacy of certain probiotics is for treatment of infectious gastroenteritis, and prevention of antibiotic-associated, Clostridioides difficile-associated and nosocomial diarrhea. Unfortunately, due to study heterogeneity and in some cases high risk of bias in published studies, a broad consensus is lacking for specific probiotic strains, doses and treatment regimens for some pediatric indications. The current available evidence thus limits the systematic administration of probiotics. The most recent meta-analyses and reviews highlight the need for more well-designed, properly powered, strain-specific and dedicated-dose response studies.

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Section: Results: Evidence Of Efficacy Of Probioticsmentioning

confidence: 99%

Probiotics in Pediatrics. A Review and Practical Guide

Depoorter

Vandenplas

2021

Nutrients

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“…The survey is constructed for self-administration. The SF-36 has also been widely used when measuring effects of allergic rhinitis on everyday life 48…”

Section: Methods and Analysismentioning

confidence: 99%

Effects of a probiotic treatment (Enterococcus faecalis) and open-label placebo on symptoms of allergic rhinitis: study protocol for a randomised controlled trial

Schaefer

Enck

2019

BMJ Open

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IntroductionSeveral studies suggest that gut microbiota may play an important role in allergic diseases. The present trial aims to examine effects of the probiotic Enterococcus faecalis on symptoms of allergic rhinitis in patients. Effects of this probiotic on the immune system have been reported by several studies, but the majority of the previous trials were animal studies. In addition, it is well known that symptoms in allergic rhinitis are prone to exhibit high placebo responses. Moreover, recent studies report that even placebos without deception (open-label placebos) are highly effective in reducing symptoms of allergic rhinitis. Our study design combines both new approaches to assess effects on allergic symptoms in patients. The objective of this study is to compare the effects of a probiotic treatment (E. faecalis) with effects seen by open-label placebo, concealed placebo treatment and no treatment control.Methods and analysisA total of 120 patients with allergic rhinitis will be randomly assigned to one of four different groups: a double-blind probiotic/placebo group (groups 1 and 2), an open-label placebo group (group 3) and a no-treatment group (group 4) to control for spontaneous variation of symptoms. The primary outcome is the evaluation of allergic symptoms using the Combined Symptoms Medication Score. Furthermore, health-related quality of life is examined (Rhinitis Quality of Life Questionnaire). Secondary outcomes include a visual analogue scale on allergic burden and a second quality of life questionnaire. This report describes the study design of the randomised controlled trial.Ethics and disseminationThe study design was approved by the ethical committee of the UKT Department of Psychosomatic Medicine and Psychotherapy, Tübingen, Germany. The trial is registered at the German Clinical Trials Register (www.drks.de, DRKS00015804). The trial results will be published in peer-reviewed journals and at conferences.Trial registration numberGerman Clinical Trials Register (www.drks.de, DRKS00015804); Pre-results.

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“…Probiotic-assisted combination therapy is also an important area of focus. In a study using a Gram-positive oral probiotic formulation ( Familact capsules) in combination with budesonide, Jalali et al 58 found that the addition of probiotics significantly improved the quality of life of AR patients compared with budesonide alone (according to SNOT-22 and control test scores for allergic rhinitis and asthma). The benefits of combined treatment with probiotics and AIT have also been studied.…”

Section: Probioticsmentioning

confidence: 99%

Research Advances in the Treatment of Allergic Rhinitis by Probiotics

Liu¹,

Hu²,

Kang³

et al. 2022

JAA

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Allergic rhinitis (AR) impairs the quality of life of patients and reduces the efficiency of social work, it is an increasingly serious public medical and economic problem in the world. Conventional anti-allergic drugs for the treatment of allergic rhinitis (AR) can cause certain side effects, which limit the quality of life of patients. Therefore, it makes sense to look for other forms of treatment. Several studies in recent years have shown that probiotics have shown anti-allergic effects in various mouse and human studies. For example, the application of certain probiotic strains can effectively relieve the typical nasal and ocular symptoms of allergic rhinitis in children and adults, thereby improving the quality of life and work efficiency. At the same time, previous studies in humans and mice have found that probiotics can produce multiple effects, such as reduction of Th2 cell inflammatory factors and/or increase of Th1 cell inflammatory factors, changes in allergy-related immunoglobulins and cell migration, regulate Th1/Th2 balance or restore intestinal microbiota disturbance. For patients with limited activity or allergic rhinitis with more attacks and longer attack duration, oral probiotics have positive effects. The efficacy of probiotics in the prevention and treatment of allergic rhinitis is remarkable, but its specific mechanism needs further study. This review summarizes the research progress of probiotics in the treatment of allergic rhinitis in recent years.

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Add‐on probiotics in patients with persistent allergic rhinitis: A randomized crossover clinical trial

Cited by 30 publications

References 38 publications

Probiotics in Pediatrics. A Review and Practical Guide

Probiotics in Pediatrics. A Review and Practical Guide

Effects of a probiotic treatment (Enterococcus faecalis) and open-label placebo on symptoms of allergic rhinitis: study protocol for a randomised controlled trial

Research Advances in the Treatment of Allergic Rhinitis by Probiotics

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