ADC as a predictor of pathologic response to neoadjuvant therapy in esophageal cancer: a systematic review and meta-analysis

L, Maffazzioli; Zilio, Mariana Blanck; Klamt, Alexandre Luis; Duarte, Juliana Ávila; Mazzini, Guilherme S.; Campos, Vinícius Jardim; Chedid, Marcio; Gurski, Richard R

doi:10.1007/s00330-020-06723-x

Cited by 8 publications

(7 citation statements)

References 38 publications

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“…None of the groups had smokers, anticoagulant agent users, polyhydramnios or chorioamnionitis, and a previous history of placental abruption. Gestational weeks at MRI examination in the control group were similar to those in the abruption group (median [range], 33.5 vs. 30.5 [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] weeks, p = 0.202).…”

Section: Resultsmentioning

confidence: 85%

“…21 The ADC values have been shown to provide helpful information for the diagnosis and evaluation of various diseases. [22][23][24] In placental MRI, reduced ADC is known as a marker of placental dysfunction, which means a decrease in the function of the placenta, which supplies oxygen and nutrients to the fetus. 14,15,[25][26][27] These findings suggest that placental abruption leads to a decrease in placental function.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of placental abruption with diffusion‐weighted imaging

Mizutani

Kotani

Kato

et al. 2022

J of Obstet and Gynaecol

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Aim: To investigate whether placental abruption without fetal distress could be assessed by apparent diffusion coefficient (ADC) values in magnetic resonance imaging (MRI). Methods: We conducted a retrospective case-control study at a single center. ADC values at the lesions of placental abruption in the abruption group (n = 8) were compared to those in the control group (n = 32). In the abruption group, ADC values at the sites of abruption were also compared to those at the nonabruption sites within the same placenta. Results: The ADC values in the placental area above the abruption site in the abruption group showed lower values than those in the control group when the slice containing the umbilical cord insertion site was set as the reference, and those values were compared in each corresponding slice. Compared with average ADC values, those above the abruption site in the abruption group were also significantly lower than those in the control group (p < 0.001). Furthermore, ADC values at the area above abruption were lower than those at the nonabruption area of all planes in the abruption group. Conclusions: ADC values at the lesions above the placental abruption site were reduced compared to those in the normal placenta and those in the nonabruption area. Thus, it would be helpful to understand the pathophysiology of placental abruption in expectant management, although further investigations would be needed.

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Section: Resultsmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Assessment of placental abruption with diffusion‐weighted imaging

Mizutani

Kotani

Kato

et al. 2022

J of Obstet and Gynaecol

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“…In a prospective study, the ADC was used to predict pCR after nCRT for esophageal cancer, achieving an AUC of 0.791 [ 23 ]. Meta-analysis revealed that changes of ADC during treatment significantly associated with pCR after neoadjuvant therapy for esophageal cancer [ 15 ]. However, baseline ADC was not associated with pathological response, indicating the ADC may not be competent for early prediction [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Conventional MR image analysis has shown promising potential in predicting pCR after nCRT in esophageal cancer. A meta-analysis including seven studies with 158 patients showed that the increase of apparent diffusion coefficient (ADC) computed from diffusion-weighted imaging (DWI) during nCRT was significantly different between pCR and non-pCR groups [ 15 ]. However, no study has explored MR radiomics, which can maximize the use of valuable image information, to predict nCRT response in esophageal cancer.…”

Section: Introductionmentioning

confidence: 99%

MR radiomics predicts pathological complete response of esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy: a multicenter study

Liu,

Wang,

Wang

et al. 2024

Cancer Imaging

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Background More than 40% of patients with resectable esophageal squamous cell cancer (ESCC) achieve pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT), who have favorable prognosis and may benefit from an organ-preservation strategy. Our study aims to develop and validate a machine learning model based on MR radiomics to accurately predict the pCR of ESCC patients after nCRT. Methods In this retrospective multicenter study, eligible patients with ESCC who underwent baseline MR (T2-weighted imaging) and nCRT plus surgery were enrolled between September 2014 and September 2022 at institution 1 (training set) and between December 2017 and August 2021 at institution 2 (testing set). Models were constructed using machine learning algorithms based on clinical factors and MR radiomics to predict pCR after nCRT. The area under the curve (AUC) and cutoff analysis were used to evaluate model performance. Results A total of 155 patients were enrolled in this study, 82 in the training set and 73 in the testing set. The radiomics model was constructed based on two radiomics features, achieving AUCs of 0.968 (95%CI 0.933–0.992) in the training set and 0.885 (95%CI 0.800-0.958) in the testing set. The cutoff analysis resulted in an accuracy of 82.2% (95%CI 72.6-90.4%), a sensitivity of 75.0% (95%CI 58.3-91.7%), and a specificity of 85.7% (95%CI 75.5-96.0%) in the testing set. Conclusion A machine learning model based on MR radiomics was developed and validated to accurately predict pCR after nCRT in patients with ESCC.

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“…It seems that DWI does not provide any additional benefit for the assessment of the ablation zone in the subacute phase after TULSA [9, 25]. Several studies have shown that an increasing ADC value after treatment can predict a response to therapy [26, 27]. This is related to processes of ablation that cause cell lysis or necrosis.…”

Section: Discussionmentioning

confidence: 99%

MR-Guided Transurethral Ultrasound Ablation of Prostate Cancer: Initial Experience of Monitoring Tumor Response by Dynamic Apparent Diffusion Coefficient Measurements at 3.0 T

Meyer¹,

Bohlscheid²,

Lemmer³

et al. 2023

Urol Int

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Introduction: Diffusion-weighted imaging (DWI) as part of multiparametric magnetic resonance imaging (mpMRI) is an important sequence for the detection of prostate cancer (PCa). The objective of this retrospective analysis was to evaluate changes in apparent diffusion coefficient (ADC) measurements in biopsy-proven PCa undergoing TULSA-PRO (MR-guided transurethral ultrasound ablation of the prostate) at 3.0 T after 1, 3, and 6–12 months posttreatment. Methods: Nineteen patients underwent follow-up examinations after 1, 3, and 6–12 months including mpMRI at 3.0 T and urological-clinical examinations with quantitative analysis of ADCs. Results: In PCa, a significant increase of ADC values after 6–12 months was measured after TULSA-PRO treatment by 29.1% (pre-TULSA: 0.79 ± 0.16 × 10−3 mm2/s, 6–12 months: 1.02 ± 0.35 × 10−3 mm2/s), while the corresponding value in the reference tissue decreased by 48.5% (pre-TULSA: 1.20 ± 0.15 × 10−3 mm2/s, 6–12 months: 0.91 ± 0.29 × 10−3 mm2/s). The mean ADC values in the early follow-up groups at 1 and 3 months did not change significantly. Conclusion: DWI with ADC as part of mpMRI can serve as a biomarker to dynamically monitor the follow-up after TULSA after 6–12 months. For early posttreatment progression, it is not suitable due to too many confounding variables.

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ADC as a predictor of pathologic response to neoadjuvant therapy in esophageal cancer: a systematic review and meta-analysis

Cited by 8 publications

References 38 publications

Assessment of placental abruption with diffusion‐weighted imaging

Assessment of placental abruption with diffusion‐weighted imaging

MR radiomics predicts pathological complete response of esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy: a multicenter study

MR-Guided Transurethral Ultrasound Ablation of Prostate Cancer: Initial Experience of Monitoring Tumor Response by Dynamic Apparent Diffusion Coefficient Measurements at 3.0 T

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