2017
DOI: 10.1172/jci91081
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Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation

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Cited by 43 publications
(48 citation statements)
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“…After blocking for 1 hour in TBS containing 0.1% Tween-20 (TBST) and 5% dry milk, the membranes were incubated overnight at 4°C with the indicated primary antibody (listed in Supplemental Table 2) in blocking buffer containing 2% dry milk. Blots were washed and incubated with HRP-conjugated secondary antibody generated in rabbit (1:5,000) or mouse (1:2,000) (Dako) for 1 hour at room temperature (66). Immunoreactive protein bands were visualized using ECL reagent (Thermo Fisher Scientific).…”
Section: Author Contributionsmentioning
confidence: 99%
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“…After blocking for 1 hour in TBS containing 0.1% Tween-20 (TBST) and 5% dry milk, the membranes were incubated overnight at 4°C with the indicated primary antibody (listed in Supplemental Table 2) in blocking buffer containing 2% dry milk. Blots were washed and incubated with HRP-conjugated secondary antibody generated in rabbit (1:5,000) or mouse (1:2,000) (Dako) for 1 hour at room temperature (66). Immunoreactive protein bands were visualized using ECL reagent (Thermo Fisher Scientific).…”
Section: Author Contributionsmentioning
confidence: 99%
“…Hearts were subsequently dehydrated in 70% ethanol, embedded in paraffin, and coronally sectioned (10-μm thickness). Sections were stained with Masson's trichrome or H&E as previously described (65,66) and then mounted and imaged using a Hamamatsu NanoZoomer 2.0HT Slide Scanning System.…”
Section: Author Contributionsmentioning
confidence: 99%
“…Altered cellular shape, connectivity and adhesion, actin dynamics, and the continuum between the cytoskeleton and the nucleus via the 'Linker of Nucleoskeleton and Cytoskeleton' complex (LINC complex), are all implicated in mechanotransduction signaling. Numerous studies demonstrated a Hippo-independent YAP regulation, highlighting a multifaceted control of YAP, especially in the heart (Ragni et al, 2017) (Hirai et al, 2017) .…”
Section: Introductionmentioning
confidence: 99%
“…Advances in molecular and genetic techniques have vastly improved the understanding of molecular mechanisms responsible for cardiomyopathies and cardiac Table 6. Animal models of left ventricular noncompaction cardiomyopathy [141][142][143][144][145][146][147][148][149][150][151][152][153][154][155][156][157][158][159]. DOI: http://dx.doi.org/10.5772/intechopen.89033 dysfunction.…”
Section: Resultsmentioning
confidence: 99%