Adaptogenic flower buds exert cancer preventive effects by enhancing the SCFA-producers, strengthening the epithelial tight junction complex and immune responses

Xia, Wenrui; Khan, Imran; Li, Xiao-ang; Huang, Guoxin; Yu, Zhi‐Ling; Leong, Wai Kit; Han, Ruixuan; Ho, Leung Tsun; Hsiao, W.L. Wendy

doi:10.1016/j.phrs.2020.104809

Cited by 48 publications

(30 citation statements)

References 73 publications

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“…The supernatant from the co-cultured bacteria decreases IL-8 production in DSS-induced colitis mice models as well [62]. More recently, butyrate has also been shown to increase the extracellular tight junction protein complexes in APCmin/+ mice model [63]. This underscores the potential role of butyrate in preventing formation and dissemination of CRC.…”

Section: The Effects Of Dietary Interventions On Colorectal Cancermentioning

confidence: 86%

Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer

Appunni¹,

Rubens²,

Ramamoorthy³

et al. 2021

Preprint

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Dietary factors play an important role in shaping the gut microbiome which, in turn, regulates the molecular events in colonic mucosa. The composition and resulting metabolism of the gut microbiome have been implicated in the development of colorectal cancer (CRC). Diets low in dietary fibers and phytomolecules as well as other lifestyle-related factors may predispose to CRC. Emerging evidence demonstrates that the predominance of microbes, such as Fusobacterium nucleatum, can predispose the colonic mucosa to malignant transformation. Dietary and lifestyle modifications have been demonstrated to restrict the growth of potentially harmful opportunistic organisms. In this study, we aim to present evidence regarding the relationship of dietary factors to the gut microbiome and development of CRC.

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Section: The Effects Of Dietary Interventions On Colorectal Cancermentioning

confidence: 86%

Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer

Appunni¹,

Rubens²,

Ramamoorthy³

et al. 2021

Preprint

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Section: Not All Additives Are Bad: Potentially Beneficial Chemical Fmentioning

confidence: 99%

“…The flower buds of adaptogenic plants, typically found in Chinese traditional medicines, including Gardenia jasminoides, Sophorae japonica, and Lonicerae japonicae, demonstrated a significant effect on reducing polyp burden, along with lowering expression of oncogenic signaling molecules in mice [53]. These changes were associated with a reduction in pathobiont microbes including Helicobacter pylori, along with an increase in beneficial microbes, including the key short chain fatty acid (SCFA) producers, Akkermansia, Barnesiella, Coprococcus, Lachnoclostridium, and Ruminococcus [53]. A diet high in seaweed has been linked with promotion of Bacteroides plebeius, which is involved in the breakdown of the seaweed Sargassum wightii to polysaccharides (SWP1 and SWP2); this significantly reduces cell proliferation and induces apoptosis in human breast cancer cell lines [54,55].…”

Section: Not All Additives Are Bad: Potentially Beneficial Chemical Fmentioning

confidence: 99%

“…Fusobacterium nucleatum [77] High-fat (keto) diet [58,77,131] B-glucuronidase [64] SCFA [132,133] Sodium phenylbutyrate [107,108,110] Colorectal Fusobacterium nucleatum [58] Clostridium butyricum, Butyricicoccus pullicaecorum Akkermansia, Barnesiella, Coprococcus, Lachnoclostridium, and Ruminococcus [53,85,99] High-fat (keto) diet [58,60,73] Red meat [21] B-glucuronidase [65] SCFA [70,72,99] Probiotics [85,86] Decursin [50] Sodium butyrate [85,99,[102][103][104][105][106] Sodium phenylbutyrate [107,108,110] Vitamin D [35] Vitamin A [37,39] Nitrates [46] Oat flakes [52] Adaptogenic flower buds [53] n-3 PUFAs [91] Polyphenols [76,78]…”

Section: Pancreaticmentioning

confidence: 99%

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The Multifaceted Roles of Diet, Microbes, and Metabolites in Cancer

Armstrong

Bording-Jorgensen

Wine

2021

Cancers

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Many studies performed to date have implicated select microbes and dietary factors in a variety of cancers, yet the complexity of both these diseases and the relationship between these factors has limited the ability to translate findings into therapies and preventative guidelines. Here we begin by discussing recently published studies relating to dietary factors, such as vitamins and chemical compounds used as ingredients, and their contribution to cancer development. We further review recent studies, which display evidence of the microbial-diet interaction in the context of cancer. The field continues to advance our understanding of the development of select cancers and how dietary factors are related to the development, prevention, and treatment of these cancers. Finally, we highlight the science available in the discussion of common misconceptions with regards to cancer and diet. We conclude this review with thoughts on where we believe future research should focus in order to provide the greatest impact towards human health and preventative medicine.

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“…Some researchers also report that the composition of the microbial community changes collectively and that some bacterial species have a strong and individual influence on carcinogenesis 34,35,36 . The predominance of the Fusobacterium genus in neoplastic tissue, for example, indicates a high risk for CRC and can be considered a potential biomarker for the development of colorectal carcinogenesis 22,26 .…”

Section: Table 1 Belowmentioning

confidence: 99%