Adaptogenic Effects of Dihydroquercetin–Chitosan Composition during Modeling of Acute Hypoxia

Murach, Elena; Baranov, I. A.; Ерлыкина, Е. И.; Koryagin, Andrey V.; Мочалова, А. Е.; Смирнова, Л. А.

doi:10.1007/s10517-014-2336-0

Cited by 4 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dihydroquercetin (DHQ) ((2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one) is a flavonoid commonly found in onions ( 16 ) , milk, thistle ( 17 ) and French maritime bark ( 18 ) . This polyphenol is classified as an antioxidant ( 19 ) and meets two of the three criteria for effective radical scavenging ability – the presence of the o -dihydroxy structure in the B ring conferring stability and the 5- and 7-OH groups with 4-oxo function in the A and C rings that are responsible for a maximum radical scavenging potential. In addition to its antioxidative effect, DHQ has been shown to have beneficial properties in cancer, CVD and liver diseases ( 20 ) .…”

mentioning

confidence: 99%

Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice

et al. 2015

View full text Add to dashboard Cite

Polyphenols have been described to have a wide range of biological activities, and many reports, published during recent years, have highlighted the beneficial effects of phenolic compounds, illustrating their promising role as therapeutic tools in several acute and chronic disorders. The purpose of study was to evaluate, in an already-assessed model of lung injury caused by bleomycin (BLM) administration, the role of resveratrol and quercetin, as well as to explore the potential beneficial properties of a mango leaf extract, rich in mangiferin, and a grape leaf extract, rich in dihydroquercetin (DHQ), on the same model. Mice were subjected to intra-tracheal administration of BLM, and polyphenols were administered by oral route immediately after BLM instillation and daily for 7 d. Treatment with resveratrol, mangiferin, quercetin and DHQ inhibited oedema formation and body weight loss, as well as ameliorated polymorphonuclear infiltration into the lung tissue and reduced the number of inflammatory cells in bronchoalveolar lavage fluid. Moreover, polyphenols suppressed inducible nitric oxide synthase expression, and prevented oxidative and nitroxidative lung injury, as shown by the reduced nitrotyrosine and poly (ADP-ribose) polymerase levels. The degree of apoptosis, as evaluated by Bid and Bcl-2 balance, was also suppressed after polyphenol treatment. Finally, these natural products down-regulated cyclo-oxygenase-2, extracellular signal-regulated kinase phosphorylated expression and reduced NF-κBp65 translocation. Our findings confirmed the anti-inflammatory effects of resveratrol and quercetin in BLM-induced lung damage, and highlight, for the first time, the protective properties of exogenous administration of mangiferin and DHQ on experimental pulmonary fibrosis.

show abstract

mentioning

confidence: 99%

Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Interestingly, the adaptogenic effect of taxifolin (dihydroquercetin) has been the subject of two studies, in which the authors confirmed that the formulation of taxifolin with chitosan as a vehicle produced a strong antihypoxic effect under conditions of experimental hypobaric hypoxia, with the lactate/pyruvate ratio much lower in the group of rats that received the taxifolin than in hypoxic animals ( Baranov et al, 2015;Murach et al, 2014). However, it is believed that the sum effect of a crude extract is most probably a synergy of different pharmacologically active compounds present in the extract, which might be responsible for the adaptogenic effect of HEHt (Wagner, 2011).…”

Section: Discussionmentioning

confidence: 98%

Heteropterys tomentosa A. Juss: Toxicological and adaptogenic effects in experimental models

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Previous studies have found that TAX bound to glyoxalic acid condensation could become a new compound consisting of two TAX unit dimers, having more effective anti-oxidant effects than TAX [ 152 ]. In addition, TAX-chitosan compositions were found to present more apparent anti-hypoxia actions in the process of preventive oral therapy under experimental hypoxia conditions than TAX alone [ 153 ]. On the other hand, in order to improve the bioavailability of TAX, γ-cyclodextrin (γ-CD) was employed as an inclusion complex.…”

Section: Bioavailability Of Taxmentioning

confidence: 99%

New Perspectives of Taxifolin in Neurodegenerative Diseases

Yang

Zhang

2023

View full text Add to dashboard Cite

Neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Cerebral amyloid angiopathy (CAA) and Huntington’s disease (HD), are characterized by cognitive and motor dysfunctions and neurodegeneration. These diseases become more severe over time and cannot be cured currently. Until now, most treatments for these diseases are only used to relieve the symptoms. Taxifolin (TAX), 3, 5, 7, 3, 4-pentahydroxy flavanone, also named dihydroquercetin, is a compound derived primarily from Douglas fir and Larix gemelini. TAX has been confirmed to present various pharmacological activities, including anti-inflammation, anti-cancer, anti-virus and regulation of oxidative stress effects. In central nervous system, TAX is demonstrated to inhibit Aβ fibril formation, protect neurons and improve cerebral blood flow, cognitive ability and dyskinesia. At present, TAX is only applied as a health additive in clinical practice. This review aimed to summarize the application of TAX in neurodegenerative diseases and the underlying neuroprotective mechanisms, such as suppressing inflammation, attenuating oxidative stress, preventing Aβ protein formation, maintaining dopamine levels and thus reducing neuronal loss.

show abstract

Adaptogenic Effects of Dihydroquercetin–Chitosan Composition during Modeling of Acute Hypoxia

Cited by 4 publications

References 5 publications

Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice

Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice

Heteropterys tomentosa A. Juss: Toxicological and adaptogenic effects in experimental models

New Perspectives of Taxifolin in Neurodegenerative Diseases

Contact Info

Product

Resources

About