Adaptogenic (Anti-Stress) Effect of Aqueous Musanga cecropioides (Urticaceae)

Owolabi, Tunde Ayobami; Ezenwa, K.C.; Olayioye, E.Y.; Iyorhibe, O.C.; Amodu, E.; Aferuan, O.F.; Okubor, P.C.; Ayinde, Buniyamin A; Okogun, Joseph I.

doi:10.20546/ijcmas.2019.810.296

Cited by 3 publications

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“…Excess cortisol synthesis in response to stress (chronic cold restraint stress) raises plasma glucose by stimulating the release of other adrenal hormones, including catecholamines. 22 Flavonoids, glycosides, triterpenoids, phytosterols (sitosterol a steroid), and phenolic compounds are the primary secondary metabolites in plants that alleviate stress. 4 Treatment of stressed animals with EECS at 200 and 400 mg/kg may reduce biochemical levels because quercetin acts on the hypothalamus to reduce CRF.…”

Section: Discussionmentioning

confidence: 99%

Pre-clinical Evaluation and In-silico Docking of Coriandrum sativum on Stress and Cognitive Defi cits in Rodents

Vanukuru¹,

Mudunuri²,

Bhimasani³

et al. 2023

IJPQA

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Ethanolic extract aerial portions of Coriandrum sativum (EECS) were tested for their anxiolytic eff ects on the cold-resistant stress test after seven days of treatment and their cognitive boosting eff ects after eight days of therapy (EECS). Total phenolic content and fl avonoid compound levels were calculated. C. sativum showed anti-stress effi cacy in a cold-resistant stress animal at 200 and 400 mg/kg doses. The plasma glucose, triglyceride, cholesterol levels, as well as the weight of the adrenal glands are all aff ected by the stimulation of the HPA in stressful situations. Pre-treatment with EECS and Geriforte, which contain secondary metabolites such as fl avonoids, glycosides, triterpenoids, and phenolic compounds, signifi cantly reduced stress-induced changes in these biochemical levels in cold stress animals. Screening for acetylcholinesterase inhibition activity in-vitro using Ellman’s approach increased AChE inhibition dose-dependently in the brains of mice. The data proved that the extract’s potential to reduce pain in-vitro is what led to the observed cognitive benefi ts in-vivo. Animals given EECS at 200 and 400 mg/kg had their infl exion ratio improved as a result of the memory defi cit being reversed. The scopolamine-induced amnesia group of mice showed degeneration of vacuolated cells, pyramidal cells, pyknosis, loss of architecture and the creation of lesions in the hippocampus; however, these characteristics were restored by EECS and standard therapy. Eff ective docking scores in mcule software were observed for interactions with receptors PDB: 4K5Y (CRF-1) for adaptogenic and PDB: 1E66 (AChE) for cognition, according to in-silico research. The ethanolic extract of C. sativum has been shown to have positive and scientifi cally-supported eff ects on human health when used as a nutraceutical, with the in-vitro acetylcholinesterase Inhibition assay, anti-stress, and cognitive enhancement activities, and in-silico studies all corroborated by this study.

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Section: Discussionmentioning

confidence: 99%

Pre-clinical Evaluation and In-silico Docking of Coriandrum sativum on Stress and Cognitive Defi cits in Rodents

Vanukuru¹,

Mudunuri²,

Bhimasani³

et al. 2023

IJPQA

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“…In this regard, the biological effects of plant extracts and their potential use as medicines have been intensively studied over the past decades [ 5 , 6 , 7 ]. Bioactive components of plant extracts are represented by an impressive diversity of secondary metabolites, which are typically involved in stress response [ 8 , 9 ], herbivore resistance [ 10 ] and protection against oxidative damage associated with vital physiological functions—photosynthesis, lipid/fatty acid metabolism and oxidative phosphorylation [ 11 ]. Not surprisingly, the secondary metabolites involved in these functions were repeatedly shown to exhibit a broad spectrum of pharmacological effects [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Characterization of Water Avens (Geum rivale L.) Extracts: Structure Assignment and Biological Activity of the Major Phenolic Constituents

Orlova

Kysil

Цветкова

et al. 2022

Plants

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Water avens (Geum rivale L.) is a common Rosaceae plant widely spread in Europe and North America. It is rich in biologically active natural products, some of which are promising as prospective pharmaceuticals. The extracts of water avens are well known for their triterpenoid metabolites and associated anti-inflammatory, antimicrobial and antioxidant activities. However, the polyphenolic profiles of G. rivale L. are still awaiting complete characterization. Accordingly, the contribution of its individual components to the antioxidant, antibacterial and neuroprotective activity of the extracts is still unknown. As this plant can be available on an industrial scale, a better knowledge of its properly-relevant constituents might give access to new highly-efficient pharmaceutical substances and functional products. Therefore, herein we comprehensively characterize the secondary metabolome of G. rivale by ESI-HR-MS, ESI-HR-MSn and NMR spectroscopy with a special emphasis on the polyphenolic composition of its aerial parts. Furthermore, a multilateral evaluation of the antioxidant, neuroprotective and antibacterial properties of the aqueous and ethyl acetate fractions of the total aqueous alcoholic extract as well as individual isolated polyphenols was accomplished. Altogether four phenolic acid derivatives (trigalloyl hexose, caffeoyl-hexoside malate, ellagic acid and ellagic acid pentoside), six flavonoids (three quercetin derivatives, kaempferol and three its derivatives and two isorhamnetin derivatives) and four tannins (HHDP-hexoside, proantocyanidin dimer, pedunculagin I and galloyl-bis-HHDP-hexose) were identified in this plant for the first time. The obtained aqueous and ethyl acetate fractions of the total extract as well as the isolated individual compounds showed pronounced antioxidant activity. In addition, a pronounced antibacterial activity against several strains was proved for the studied fractions (for ethyl acetate fraction the highest activity against E. coli АТСС 25922 and S. aureus strains ATCC 27853 and SG-511 (MIC 15.6 μg/mL) was observed; for aqueous fraction—against Staphylococcus aureus SG-511 (MIC 31.2 μg/mL)). However, the anti-neurodegenerative (neuroprotective) properties could not be found with the employed methods. However, the antibacterial activity of the fractions could not be associated with any of the isolated individual major phenolics (excepting 3-O-methylellagic acid). Thus, the aerial parts of water avens represent a promising source of polyphenolic compounds with antioxidant activity and therefrom derived human health benefits, although the single constituents isolated so far lack a dominant selectively bioactive constituent in the bioassays performed.

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Examination of Medicinal Plants for Radionuclides Absorption and Their Health Implications

Popoola,

Isola,

Fakeye

et al. 2023

Preprint

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This study tests the concentration of 40K, 238U, and 232Th radionuclides and also evaluates the possible radiological health risks in medicinal plants found in Ewu, Edo State, Nigeria, using a NaI(Tl) gamma spectrometer. The six selected medicinal plants are Magnifera indica, Dacryodes edulis, Terminalia catappa, Cymbopogon citratus, Anacardium occidentale, and Persea Americana. The results showed that the activity concentrations for 40K ranged from 146.59 ± 4.81 in Persea americana to 296.08 3.42 Bq/kg in Cymbopogon citratus with a mean of 209.43 ± 5.14 Bq/kg, 238U ranged from 2.25 ± 0.06 to 5.57 ± 0.15 Bq/kg with a mean of 4.73 ± 0.15 Bq/kg and 232Th varied from 4.50 ± 0.35 to 12.07 ± 0.57 Bq/kg with a mean of 8.00 ± 0.40 Bq/kg. The maximum and minimum activity concentrations of both 238U and 232Th were found in Magnifera indica and Cymbopogon citratus respectively. The calculated radiological hazards assessment due to the investigated medicinal plants is well within the internationally recommended safe limits. 232Th contributes 54.91% to the total ECED , while 6.35% for 238U is the least. 232Th exhibit a very strong, positive, and significant relationship with (ECED and ELCR), and it contributes largely to the ECED and ELCR due to ingestion of the examined herbal plant. Therefore, the use of these medicinal plants is radiologically safe for human consumption.

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Adaptogenic (Anti-Stress) Effect of Aqueous Musanga cecropioides (Urticaceae)

Cited by 3 publications

References 0 publications

Pre-clinical Evaluation and In-silico Docking of Coriandrum sativum on Stress and Cognitive Defi cits in Rodents

Pre-clinical Evaluation and In-silico Docking of Coriandrum sativum on Stress and Cognitive Defi cits in Rodents

Phytochemical Characterization of Water Avens (Geum rivale L.) Extracts: Structure Assignment and Biological Activity of the Major Phenolic Constituents

Examination of Medicinal Plants for Radionuclides Absorption and Their Health Implications

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