Adaptogenic activity of Trigonella foenum graecum (Linn) seeds in rodents exposed to anoxia and immobilization stress

Pawar, Vinod S; Hugar, Shivakumar

doi:10.1016/s2221-1691(12)60161-0

Cited by 16 publications

(11 citation statements)

References 11 publications

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“…In stress-induced animals, spleen contracts and releases more amounts of lymphocytes, neutrophils and eosinophils into circulations. [ 13 ] Pretreatment with E. aureum extract have shown to significantly reduce the number of white blood cells parameters. The adaptogenic activity may be attributed due to the presence of flavonoids in the E. aureum extract.…”

Section: Discussionmentioning

confidence: 99%

An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract

et al. 2017

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Background:Stress is a normal part of everyday life but chronic stress can lead to a variety of stress-related illnesses including hypertension, anxiety, and depression. In the present investigation, standardized leaf extract of Epipremnumaureum was evaluated for its anti-stress potential.Materials and Methods:For the evaluation of anti-stress activity, groups of mice (n = 6) were subjected to forced swim stress and anoxic stress tolerance test in mice 1h after daily treatment of E.aureumextract. Diazepam (5 mg/kg) was taken as a reference standard. Urinary vanillylmandelic acid (VMA) and ascorbic acid were selected as noninvasive biomarkers to assess the anti-stress activity and plasma cortisol, blood ascorbic acid, and weight of adrenal were measured. The 24 h urinary excretion of VMA and ascorbic acid were determined by spectrophotometric methods in all groups under normal and stressed conditions. The hematological parameters (neutrophils, lymphocytes, and eosinophils) were also determined.Results:Administration of E.aureumat doses of 400 and 600 mg/kg wasfound to be effective in inhibiting the stress induced urinary biochemical changes in a dose-dependent manner. Treatment with E. aureum extract prevents the rise in blood ascorbic acid and plasma cortisol. Moreover, the extract prevented the increase in weight of adrenal gland also significantly increased the anoxia stress tolerance time. Dose-dependent significant reduction in white blood cell count was observed in anoxic stress tolerance test as compared to stressed group.Conclusion:Hence, the present study provides scientific support for the positiveadaptogenic effect of E. aureum extract.

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Section: Discussionmentioning

confidence: 99%

An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract

et al. 2017

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“…Cortisol increases mRNA level in liver cells. Spleen constricts to release more blood cells (RBC and WBC) during stress, so their weights decrease in stress [ 22 ]. This stress induced changes were significantly reversed by the test extract at lower and higher doses.…”

Section: Discussionmentioning

confidence: 99%

Adaptogenic Activity of Lyophilized Hydroethanol Extract of Pandanus odoratissimus in Swiss Albino Mice

Adkar

Jadhav

Ambavade

et al. 2014

International Scholarly Research Notices

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Background. The leaves of Pandanus odoratissimus Linn have been widely used in Ayurveda to treat a variety of common and stress related disorders. In the present investigation, hydroethanol extract of leaves of Pandanus odoratissimus Linn (LEPO) were evaluated for antistress activity in normal and stress induced mice. Furthermore, the extract was studied for nootropic (adaptogenic) activity in mice and in vitro antioxidant potential to correlate with its adaptogenic and antistress activity. LEPO (100 and 200 mg/kg p.o) was evaluated against forced swimming endurance stress test, anoxia stress tolerance and immobilization stress and chronic cold resistant stress tests, and biomarkers (serum glucose, Corticosterone, WBC, RBC, and DLC count) to assess the antistress activity in mice. Withania somnifera (WS) (100 mg/kg p.o) was selected as reference standard. The parameters like anoxia stress tolerance time were recorded in anoxia stress and estimation of biochemical marker levels and determination of organs weight were carried out in immobilization stress models. Results. Concomitant treatment with LEPO 200 mg/kg significantly increased in anoxia stress tolerance time. Dose dependent significant reduction in serum glucose, corticosterone, and WBC, RBC, and DLC was observed in immobilisation stress model as compared to stressed group. LEOP 200 mg/kg and WS 100 mg/kg significantly reversed/inhibited the stress induced changes in these parameters. The results from the present study indicate that these values also express that dose dependent significant adaptogenic activity in stressed animals. Conclusion. The present study provides scientific support for the antistress (adaptogenic) and nootropic activities of lyophilized hydroethanol extract of Pandanus odoratissimus Linn and substantiate the traditional claims for the usage of Pandanus in stress induced disorders.

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“…The results of the study showed that the extract offered strong antioxidant activity in a concentration dependent manner [38] .…”

Section: Pharmacological Studiesmentioning

confidence: 94%

“… Antistress study Pawar and Hugar (2012) studied the adaptogenic activity of methanolic extract of Trigonella foenum-graecum seeds (METFGS) at 100, 250 and 500 mg/kg doses against anoxia stress tolerance in mice and immobilization stress models. The results of the study showed marked increase in anoxia stress tolerance time.…”

Section: Pharmacological Studiesmentioning

confidence: 99%

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2018

Int. J. Res. Pharm. Pharm. Sci.

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Unani medicine of system has gained popularity among the society in current scenario. They have been used for their scent, flavor, or therapeutic properties. Methi or Trigonella foenum-graecum (TFG) belonging to the family Fabaceae is an aromatic perennial herb which is cultivated throughout India. It is widely used in cosmetic and flavoring industries. It is included in the formulations used for chloasma, improving complexion and beautification. According to Unani classical literature, its suppository was made in conjunction with duck fat and introduced into the body to cure cirrhosis of the uterus and its mouth opened up. It is extensively used for several human diseases mentioned in Unani system of medicine. Various scientific/ experimental studies have been performed presently on TFG namely, phytochemical, physicochemical, pharmacological and clinical studies. In this review, Various actions and clinical indications have been elaborated in the Unani classical literature and some properties namely Antiinflammatory, An-diabetic, Antiarthritic, Antiglycemic, Antioxidant and Anti-stress activities have been revalidated in the light of recent scientific researches. Significant information about METHI as a traditional herbal medicine is provided in this review.

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Adaptogenic activity of Trigonella foenum graecum (Linn) seeds in rodents exposed to anoxia and immobilization stress

Cited by 16 publications

References 11 publications

An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract

An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract

Adaptogenic Activity of Lyophilized Hydroethanol Extract of Pandanus odoratissimus in Swiss Albino Mice

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