Adaptive weighted sum tests via LASSO method in multi-locus family-based association analysis

Li, Rui; Yuan, Min; Huang, Xu; Chen, Pinzhong; Xu, Xu Steven; Yang, Yaning

doi:10.1016/j.compbiolchem.2020.107320

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…To eliminate variables, the L1 penalty could force coefficient estimates to zero (7). This method could circumvent the necessity for explicit multiple testing correction and prevent overfitting of the model (8). It is increasingly common in the genetic field and others, but it is seldom used in BPD prediction (9).…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Nomogram for Predicting Bronchopulmonary Dysplasia in Very-Low-Birth-Weight Infants

et al. 2021

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Background: Bronchopulmonary dysplasia is a common pulmonary disease in newborns and is one of the main causes of death. The aim of this study was to build a new simple-to-use nomogram to screen high-risk populations.Methods: In this single-center retrospective study performed from January 2017 to December 2020, we reviewed data on very-low-birth-weight infants whose gestational ages were below 32 weeks. LASSO regression was used to select variables for the risk model. Then, we used multivariable logistic regression to build the prediction model incorporating these selected features. Discrimination was assessed by the C-index, and and calibration of the model was assessed by and calibration curve and the Hosmer-Lemeshow test.Results: The LASSO regression identified gestational age, duration of ventilation and serum NT-proBNP in the 1st week as significant predictors of BPD. The nomogram-illustrated model showed good discrimination and calibration. The C-index was 0.853 (95% CI: 0.851–0.854) in the training set and 0.855 (95% CI: 0.77–0.94) in the validation set. The calibration curve and Hosmer-Lemeshow test results showed good calibration between the predictions of the nomogram and the actual observations.Conclusion: We demonstrated a simple-to-use nomogram for predicting BPD in the early stage. It may help clinicians recognize high-risk populations.

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Section: Introductionmentioning

confidence: 99%

Development and Validation of a Nomogram for Predicting Bronchopulmonary Dysplasia in Very-Low-Birth-Weight Infants

et al. 2021

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“…The Lasso regression method performs variable selection as an alternative to the subset selection method to reduce model complexity. This method can prevent the model from overfitting and avoids the need for multiple test corrections ( 15 ). Normally distributed data are presented as mean ± standard deviation, and nonnormally distributed data are presented as medians and interquartile ranges.…”

Section: Methodsmentioning

confidence: 99%

A prediction nomogram for moderate-to-severe bronchopulmonary dysplasia in preterm infants < 32 weeks of gestation: A multicenter retrospective study

Zhang

Wei

et al. 2023

Front. Pediatr.

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BackgroundModerate-to-severe bronchopulmonary dysplasia (msBPD) is a serious complication in preterm infants. We aimed to develop a dynamic nomogram for early prediction of msBPD using perinatal factors in preterm infants born at <32 weeks' gestation.MethodsThis multicenter retrospective study conducted at three hospitals in China between January 2017 and December 2021 included data on preterm infants with gestational age (GA) < 32 weeks. All infants were randomly divided into training and validation cohorts (3:1 ratio). Variables were selected by Lasso regression. Multivariate logistic regression was used to build a dynamic nomogram to predict msBPD. The discrimination was verified by receiver operating characteristic curves. Hosmer-Lemeshow test and decision curve analysis (DCA) were used for evaluating calibration and clinical applicability.ResultsA total of 2,067 preterm infants. GA, Apgar 5-min score, small for gestational age (SGA), early onset sepsis, and duration of invasive ventilation were predictors for msBPD by Lasso regression. The area under the curve was 0.894 (95% CI 0.869–0.919) and 0.893 (95% CI 0.855–0.931) in training and validation cohorts. The Hosmer−Lemeshow test calculated P value of 0.059 showing a good fit of the nomogram. The DCA demonstrated significantly clinical benefit of the model in both cohorts. A dynamic nomogram predicting msBPD by perinatal days within postnatal day 7 is available at https://sdxxbxzz.shinyapps.io/BPDpredict/.ConclusionWe assessed the perinatal predictors of msBPD in preterm infants with GA < 32 weeks and built a dynamic nomogram for early risk prediction, providing clinicians a visual tool for early identification of msBPD.

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Method construction of structure-property relationships from data by machine learning assisted mining for materials design applications

Dai

Liu

et al. 2020

Materials & Design

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Adaptive weighted sum tests via LASSO method in multi-locus family-based association analysis

Cited by 3 publications

References 25 publications

Development and Validation of a Nomogram for Predicting Bronchopulmonary Dysplasia in Very-Low-Birth-Weight Infants

Development and Validation of a Nomogram for Predicting Bronchopulmonary Dysplasia in Very-Low-Birth-Weight Infants

A prediction nomogram for moderate-to-severe bronchopulmonary dysplasia in preterm infants < 32 weeks of gestation: A multicenter retrospective study

Method construction of structure-property relationships from data by machine learning assisted mining for materials design applications

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