Adaptive Treatment for Youth With Substance Use and Depression: Early Depression Response and Short-term Outcomes

Application of the RDoC Framework to Predict Alcohol Use and Suicidal Thoughts and Behaviors among Early Adolescents in the Adolescent Brain and Cognitive Development (ABCD) Study

“…Third, given the co-occurrence of ALC and STBs in youth as young as 9 years, personalized treatments to meet this high-risk group are needed. To date, there is currently no standard approach to treating co-occurring ALC and STBs, but motivational enhancement therapy or cognitive behavioral therapy approaches have demonstrated efficacy [ 82 , 83 ]. Unfortunately, ALC and STBs are often treated in two separate systems of care, and usually with older adolescents, highlighting an important and unmet need [ 82 , 83 ].…”

“…To date, there is currently no standard approach to treating co-occurring ALC and STBs, but motivational enhancement therapy or cognitive behavioral therapy approaches have demonstrated efficacy [ 82 , 83 ]. Unfortunately, ALC and STBs are often treated in two separate systems of care, and usually with older adolescents, highlighting an important and unmet need [ 82 , 83 ]. However, one intervention to highlight is a two-site randomized control trial that recruited 95 participants aged 13–21, with depression and substance use, led by John Curry, PhD, MD, and Yifrah Kaminer, MD, MBA at the University of Connecticut (J. Curry, personal communication, 14 June 2022) [ 83 ].…”

“…Unfortunately, ALC and STBs are often treated in two separate systems of care, and usually with older adolescents, highlighting an important and unmet need [ 82 , 83 ]. However, one intervention to highlight is a two-site randomized control trial that recruited 95 participants aged 13–21, with depression and substance use, led by John Curry, PhD, MD, and Yifrah Kaminer, MD, MBA at the University of Connecticut (J. Curry, personal communication, 14 June 2022) [ 83 ]. The trial includes an adaptive method, such that initial substance use treatment (CBT) is supplemented with one of two depression treatments (CBT-for-depression [CBT-D], or treatment-as-usual [TAU] only when needed.…”

Barriers for recruitment to treatment of youths with co‐occurring substance use disorders and depression

“…Consequently, this report aims to compare two treatment studies conducted at the same site using similar recruitment procedures by the same team of research assistants and investigators. The first study was for adolescents with a mono‐diagnosis of SUD, mainly cannabis use disorder (CUD) or harmful alcohol use, 16 and the second study was for adolescents with SUD (mostly CUD or harmful alcohol use) and COD 17 . We hypothesized that in comparison to adolescents with SUD diagnosis only, those with SUD‐COD would be significantly more challenging to recruit and retain in the pretreatment assessment phase.…”

“…The first study was for adolescents with a monodiagnosis of SUD, mainly cannabis use disorder (CUD) or harmful alcohol use, 16 and the second study was for adolescents with SUD (mostly CUD or harmful alcohol use) and COD. 17 We hypothesized that in comparison to adolescents with SUD diagnosis only, those with SUD-COD would be significantly more challenging to recruit and retain in the pretreatment assessment phase. Furthermore, we examined the role of the female gender as a potential moderator for retention in the pretreatment phase due to the preponderance of females with depression compared to males (without formulating a hypothesis).…”