Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects

Abstract

Supramolecular structures, such as micelles, liposomes, polymerosomes or dendrimerosomes, are widely studied and used as drug delivery systems. The behavior of amphiphilic building blocks strongly depends on their spatial distribution and shape of polar and nonpolar component. This report is focused on the development of new versatile synthetic protocols for amphiphilic carbosilane dendrons (amp-CS-DDNs) capable of self-assembly to regular micelles and other supramolecular objects. The presented strategy enables the fine modification of amphiphilic structure in several ways and also enables the facile connection of a desired functionality. DLS experiments demonstrated correlations between structural parameters of amp-CS-DDNs and the size of formed nanoparticles. For detailed information about the organization and spatial distribution of amp-CS-DDNs assemblies, computer simulation models were studied by using molecular dynamics in explicit water.

Metallo-Glycodendrimeric Materials against Enterotoxigenic Escherichia coli

“…Another hypothesis suggests that the antibacterial activity of glycodendrimer loaded with metal nanoparticles results from the release of corresponding ions via the oxidation dissolution process. Metal ions oxidized from corresponding metal-loaded materials mainly interact with thiol groups of various enzymes and proteins, thereby interfering with the respiratory chain and disrupting the bacterial cell wall [46]. In addition, it is known that silver ions are involved in the generation of reactive oxygen species (ROS), which are considered the main cause of most cell deaths via the inactivation of DNA replication and ATP production [47].…”