Adaptive strategies of aquatic mammals: Exploring the role of the HIF pathway and hypoxia tolerance
Yuri Yépez,
Mariana Marcano-Ruiz,
Maria Cátira Bortolini
Abstract:Aquatic mammals (marine and freshwater species) share significant and similar adaptations, enabling them to tolerate hypoxia during regular breath-hold diving. Despite the established importance of
HIF1A
, a master regulator in the molecular mechanism of hypoxia response, and other associated genes, their role in the evolutionary adaptation of aquatic mammals is not fully understood. In this study, we investigated this topic by employing a candidate gene approach to analyze 11 critical g… Show more
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