This paper reviews research that studies the principle of self-support (PSS) in some control systems and proposes a fractional-order generalized PSS framework for the first time. The existing PSS approach focuses on practical tracking problem of integer-order systems including robotic dynamics, high precision linear motor system, multi-axis high precision positioning system with unmeasurable variables, imprecise sensor information, uncertain parameters and external disturbances. More generally, by formulating the fractional PSS concept as a new generalized framework, we will focus in the possible fields on the fractional-order control problems such as practical tracking, λ-tracking, etc. of robot systems, multiple mobile agents, discrete dynamical systems, time delay systems and other uncertain nonlinear systems. Finally, the practical tracking of a first-order uncertain model of automobile is considered as a simple example to demonstrate the efficiency of the fractional-order generalized principle of self-support (FOGPSS) control strategy.