Adaptive Responses of Secretory Cardiomyocytes of the Right Atrium during Simulation of Microgravity Effects by Long-Term and Repeated Antiorthostatic Tail Suspension of Rats

Погодина, Л.С.; Shornikova, M. V.; Chentsov, Yu. S.

doi:10.1023/b:bibu.0000014350.53367.b7

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…Martel et al recorded signs of transient tachycardia in rats after 24 h of TS, while Fagette et al did not find changes in blood pressure or heart rhythm in two separate occasions (rats subjected to 3 days of TS and rats subjected to 13 days of TS) (Fagette et al, 1994 , 1995 ; Martel et al, 1994 ). Nonetheless, two later studies showed impaired contractility in isolated CM from rats in TS for 7 and 14 days (Dunlap et al, 1996 ; Pogodina et al, 2004 ). Respress et al reported an increase in susceptibility of arrhythmia due to changes in Ca 2+ handling after 28 and 56 days of TS in mice (Respress et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

“…This partly confirms previous reports, although tail suspension‐induced cardiac phenotypes cover a wide spectrum. From the literature, it appears that four to 8 weeks of physical inactivity induced by tail suspension leads to cardiac malfunction, remodeling, and atrophy that is challenging recuperated after rest (Pogodina et al, 2004 ; Zhong et al, 2016 ). Our results show that even a short period of 2 weeks of physical inactivity induces cardiac alterations at the molecular level that can be cover both benign and hostile spectra linked with maladaptive hypertrophy.…”

Section: Discussionmentioning

confidence: 99%

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Physical inactivity by tail suspension alters markers of metabolism, structure, and autophagy of the mouse heart

Rojo‐García

Vanmunster

Pacolet

et al. 2023

Physiological Reports

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Sedentary behavior has become ingrained in our society and has been linked to cardiovascular diseases. Physical inactivity is the main characteristic of sedentary behavior. However, its impact on cardiovascular disease is not clear. Therefore, we investigated the effect of physical inactivity in an established mouse model on gene clusters associated with cardiac fibrosis, electrophysiology, cell regeneration, and tissue degradation/turnover. We investigated a sedentary group (CTR, n = 10) versus a tail suspension group (TS, n = 11) that caused hindlimb unloading and consequently physical inactivity. Through histological, protein content, and transcript analysis approaches, we found that cardiac fibrosis‐related genes partly change, with significant TS‐associated increases in Tgfb1, but without changes in Col1a1 and Fn1. These changes are not translated into fibrosis at tissue level. We further detected TS‐mediated increases in protein degradation‐ (Trim63, p < 0.001; Fbxo32, p = 0.0947 as well as in biosynthesis‐related [P70s6kb1, p < 0.01]). Corroborating these results, we found increased expression of autophagy markers such as Atg7 (p < 0.01) and ULK1 (p < 0.05). Two cardiomyocyte regeneration‐ and sarcomerogenesis‐related genes, Yap (p = 0.0535) and Srf (p < 0.001), increased upon TS compared to CTR conditions. Finally, we found significant upregulation of Gja1 (p < 0.05) and a significant downregulation of Aqp1 (p < 0.05). Our data demonstrate that merely 2 weeks of reduced physical activity induce changes in genes associated with cardiac structure and electrophysiology. Hence, these data should find the basis for novel research directed to evaluate the interplay of cardiac functioning and physical inactivity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Physical inactivity by tail suspension alters markers of metabolism, structure, and autophagy of the mouse heart

Rojo‐García

Vanmunster

Pacolet

et al. 2023

Physiological Reports

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“…Mitochondria are the most labile structures in CMC, one of the first to react to any changes. The number of intermitochondrial junctions between them is a dynamically changing criterion, reflecting the level of functional activity of CMC in general (Procenko et al, 1995;Shornikova, 2000, Pogodina et al, 2004. Therefore, study of the CMC mitochon driom is very interesting at any exposure, particularly at those that do not cause extremely pronounced changes in the ultrastructures of these cells or even for brief exposures.…”

mentioning

confidence: 99%

Electron microscope analysis of cardiomyocytes in the rat left ventricle under simulation of weightlessness effects and artificial gravitation

Вареник

Lipina

Shornikova

et al. 2012

Biol Bull Russ Acad Sci

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Electron microscopic study of left ventricle cardiomyocytes and quantitative analysis of their mitochondriom was performed in rats exposed to tail suspension, as a model of weightlessness effects, to arti ficial gravity produced by intermittent 2 G centrifugation and a combination of these effects. It was found that the cardiomyocytes ultrastructure changed slightly after tail suspension and after intermittent 2 G influence, as well as under a combination of these effects. However, the number of intermitochondrial junctions increased significantly in the interfibrillar zone of cardiomyocytes under a combination of tail suspension and intermittent 2 G influence, which agrees with the cell hypertrophy described earlier.

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Adaptive Responses of Secretory Cardiomyocytes of the Right Atrium during Simulation of Microgravity Effects by Long-Term and Repeated Antiorthostatic Tail Suspension of Rats

Cited by 2 publications

References 13 publications

Physical inactivity by tail suspension alters markers of metabolism, structure, and autophagy of the mouse heart

Physical inactivity by tail suspension alters markers of metabolism, structure, and autophagy of the mouse heart

Electron microscope analysis of cardiomyocytes in the rat left ventricle under simulation of weightlessness effects and artificial gravitation

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