Adaptive Response of Humans to Changes in Dietary Calcium: Relationship Between Vitamin D Regulated Intestinal Function and Serum 1,25-Dihydroxyvitamin D Levels

Bikle, Daniel D.; Herman, Robert H.; Hull, Sam; Hagler, Louis; Harris, Dale B.; Halloran, Bernard P.

doi:10.1016/s0016-5085(83)80129-2

Cited by 9 publications

(3 citation statements)

References 20 publications

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“…3. 1991 reliable indicator of vitamin D action in the small intestine and therefore possibly involved in intestinal calcium absorption (15). However, in a previous study we did not find any close relationship between plasma 1,25-dihydroxyvitamin D or calbindin-D 9K and intestinal alkaline phosphatase activity (7).…”

Section: Discussionmentioning

confidence: 94%

Measurement of Calbindin‐D_9K in Small Intestinal Biopsy Specimens of Children

Staun,

Pærregaard,

Krasilnikoff

1991

J. pediatr. gastroenterol. nutr.

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SummaryThe vitamin D dependent intestinal calcium‐binding protein (calbindin‐D9K) was measured by an enzyme‐linked immunoadsorbent assay in small intestinal biopsy specimens from 10 children (aged 15–126 months). The aim was to study the relationship between calcium‐binding protein and age, bone age, and height. The patients were examined due to complaints of chronic diarrhea, but no evidence of malabsorption was found. The amount of calbindin‐D9K per mg of soluble protein in the small intestinal biopsy specimens was higher than previously studied in normal adults. Calbindin‐D9K correlated inversely with chronological age, bone age, and height of the children (p = −0.87, p = −0.66, and p = – 0.66; p < 0.05). A direct correlation was found between calbindin‐D9K and intestinal alkaline phosphatase activity (p = 0.60; p < 0.05). The decline in calbindin‐D9K may indicate that the active vitamin D dependent intestinal calcium absorption decreases during childhood.

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Section: Discussionmentioning

confidence: 94%

Measurement of Calbindin‐D_9K in Small Intestinal Biopsy Specimens of Children

Staun,

Pærregaard,

Krasilnikoff

1991

J. pediatr. gastroenterol. nutr.

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“…Previous studies have shown variable effects of increased calcium intake on serum PTH levels 16 , 17 , 18 . Recently, Orwoll et al 19 studied a group of men whose diets were supplemented with calcium and vitamin D. They observed a slight decline in serum PTH levels without evidence of a decline in bone loss measured at peripheral and axial sites.…”

Section: Discussionmentioning

confidence: 99%

“…8-1 through No. [8][9][10][11][12][13][14][15][16]. Questionnaires relating to gastrointestinal symptoms (nausea, constipation, diarrhea) were completed by subjects at baseline and at the end of the 6-month study period.…”

Section: Methodsmentioning

confidence: 99%

The Metabolic Effects of Calcium Supplementation in the Elderly

Kochersberger¹,

Westlund²,

Lyles³

1991

J American Geriatrics Society

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Because the value of calcium supplementation in age-related bone loss is controversial, we conducted a study to examine the effects of six months of calcium supplementation on parathyroid hormone (PTH) and other indices of bone metabolism. Calcium carbonate (1.2 grams elemental calcium/day) or placebo was administered for 6 months to a group of 42 healthy, ambulatory men and women with a mean age of 71. Fasting blood samples and 2-hour urine collections were performed at baseline and at 1 and 6 months. The decline in serum PTH levels from baseline in the calcium-supplemented group was significant in comparison with the placebo group changes (for the calcium group: 40.9 pg/mL at baseline to 34.0 pg/mL at 1 month and 33.2 at 6 months). This drop in PTH was associated with a decline in 1,25 OH-Vitamin D levels from a mean of 38.3 pg/mL to 30.4 pg/mL at 1 month and 31.9 at 6 months. During calcium supplementation, no changes were observed in serum bone Gla protein values. A decline in urinary hydroxyproline excretion was observed at 6 months, but this did not reach significant levels. The present study demonstrates suppression of PTH levels with calcium supplementation, an effect which lasts at least 6 months. This change was accompanied by a decrease in serum 1,25 OH-Vitamin D. The lack of significant changes in either serum bone gla protein or urine hydroxyproline excretion fails to support any significant change in bone turnover occurring with this decrease in PTH.

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Calcium-binding protein in human duodenal biopsies

et al. 1988

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Intestinal calcium-binding protein (CaBP) (molecular weight 10,000) was measured by a specific enzyme-linked immunoadsorbent assay in duodenal biopsies of 94 patients (aged 20-89 years). The patients were examined for complaints of upper abdominal dyspepsia, but no significant pathology was found by gastroduodenoscopy. The median amount of CaBP in duodenal biopsies was 6.0 micrograms/mg of cytosolic protein with a coefficient of variation of 0.6. No change in the amount of CaBP per mg of cytosolic protein was observed with age. A significant correlation (P less than 0.001) was found between the concentration of CaBP and s-1,25-dihydroxyvitamin D (1,25(OH)2D). The amount of CaBP per mg of cytosolic protein did not correlate with immunoreactive parathyroid hormone in serum, and no relation between CaBP and the specific activity of alkaline phosphatase of the mucosal biopsies was found. The results of the present study show a wide variation in the amount of the 10 kDa CaBP in duodenal biopsies of humans and no change with age. Further, a correlation between s-1,25(OH)2D and CaBP was found.

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Adaptive Response of Humans to Changes in Dietary Calcium: Relationship Between Vitamin D Regulated Intestinal Function and Serum 1,25-Dihydroxyvitamin D Levels

Cited by 9 publications

References 20 publications

Measurement of Calbindin‐D_9K in Small Intestinal Biopsy Specimens of Children

Measurement of Calbindin‐D_9K in Small Intestinal Biopsy Specimens of Children

The Metabolic Effects of Calcium Supplementation in the Elderly

Calcium-binding protein in human duodenal biopsies

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Adaptive Response of Humans to Changes in Dietary Calcium: Relationship Between Vitamin D Regulated Intestinal Function and Serum 1,25-Dihydroxyvitamin D Levels

Cited by 9 publications

References 20 publications

Measurement of Calbindin‐D9K in Small Intestinal Biopsy Specimens of Children

Measurement of Calbindin‐D9K in Small Intestinal Biopsy Specimens of Children

The Metabolic Effects of Calcium Supplementation in the Elderly

Calcium-binding protein in human duodenal biopsies

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Product

Resources

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Measurement of Calbindin‐D_9K in Small Intestinal Biopsy Specimens of Children

Measurement of Calbindin‐D_9K in Small Intestinal Biopsy Specimens of Children