Adaptive Planning and Delivery to Account for Anatomical Changes Induced by Radiation Therapy of Head and Neck Cancer

Cone-Beam CT Assessment of Interfraction and Intrafraction Setup Error of Two Head-and-Neck Cancer Thermoplastic Masks

“…Some authors have suggested that thermoplastic head-andneck immobilization can perform as well as that used for stereotactic radiotherapy when combined with CBCT image guidance (15). Provided intrafraction motion is managed, interfraction reproducibility may become less important as online adaptive radiotherapy becomes available in the clinic for head-and-neck cancer patients (37,38).…”

Deformable Image Registration for Radiation Therapy Planning: Algorithms and Applications

“…Sharpe et al investigated the benefit of ART for head and neck cancer using linear elastic body deformable registration, based on surface mesh propagation and weekly MR images registered to a planning kVCT image. 30 The study investigated the benefits of an offline adaptive planning technique, which generated a new treatment plan each week over the course of radiotherapy, in the limit of reducing PTV margins. The study showed that setup uncertainties and anatomic changes produced significant dose variation over the course of treatment when the original treatment plan was delivered over the entire course of radiotherapy.…”

Image‐guided radiotherapy is being overvalued as a clinical tool in radiation oncology

“…I compliment the authors for exploring this relationship and bringing their observations to the forefront. Daily image-guidance data about the day-to-day positioning of the patient will elucidate the role that important factors such as bowel filling, 7,8 respiratory-induced motion, 9 lung target deformation, 10 and radiation-induced changes in the geometry of normal and target tissues 11,12 have in limiting the precision of radiation delivery.…”