In this paper, a novel disturbance-observer-based approximate dynamic inversion (ADI) approach is developed for pure-feedback nonaffine-in-control nonlinear systems (PFNNSs) in the presence of both high-order mismatched disturbances and actuator saturation. Finite-time disturbance observers (FTDOs) are utilized to estimate the disturbances and their derivatives. Then, we rebuild the system with the outputs of FTDOs. Thereafter, ADI is employed to derive the desired virtual and actual control of the nominal system, where no disturbances and saturation are presented. Furthermore, an augmented intermediate subsystem is constructed for the reduced slow subsystem to compensate for the difference between inputs with and without saturation by approximating its inversion. The stability of the closed-loop system is studied using Tikhonov's theorem. The proposed method is applied to a numerical example and a one-link robotic system with a brush DC motor. The simulation results demonstrate the validity of the presented approach. INDEX TERMS High-order mismatched disturbances, actuator saturation, finite-time disturbance observer, approximate dynamic inversion, singular perturbation theory.