Abstract-In this paper, adaptive neural control is investigated for a class of unknown nonlinear systems in purefeedback form with the generalized Prandtl-Ishlinskii hysteresis input. The non-affine problem both in the pure-feedback form and in the generalized Prandtl-Ishlinskii hysteresis input function is solved by adopting the Mean Value Theorem. By utilizing Lyapunov synthesis, the closed-loop control system is proved to be semi-globally uniformly ultimately bounded (SGUUB), and the tracking error converges to a small neighborhood of zero. Simulation results are provided to illustrate the performance of the proposed approach.