2008 International Conference on Machine Learning and Cybernetics 2008
DOI: 10.1109/icmlc.2008.4620435
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Adaptive neighborhood selection for manifold learning

Abstract: How the organization of genes on a chromosome shapes adaptation is essential for understanding evolutionary paths. Here, we investigate how adaptation to rapidly increasing levels of antibiotic depends on the chromosomal neighborhood of a drug-resistance gene inserted at different positions of the Escherichia coli chromosome. Using a dual-fluorescence reporter that allows us to distinguish gene amplifications from other up-mutations, we track in real-time adaptive changes in expression of the drug-resistance g… Show more

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Cited by 6 publications
(2 citation statements)
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“…Thus, in order to give full play to the abilities of NPE, an adaptive neighborhood algorithm is taken. The algorithm can select the optimal neighbor parameter k only depending on the input data, which is based on estimates of intrinsic dimensionality and tangent orientation [43].…”
Section: ) Npe Convolutionmentioning
confidence: 99%
“…Thus, in order to give full play to the abilities of NPE, an adaptive neighborhood algorithm is taken. The algorithm can select the optimal neighbor parameter k only depending on the input data, which is based on estimates of intrinsic dimensionality and tangent orientation [43].…”
Section: ) Npe Convolutionmentioning
confidence: 99%
“…To address the above issues, we introduce a complementary spectrum as a supplement to the experimental spectrum, which has been proven useful in database search methods [8] . MS2 data can be represented as a set of peaks {(đť‘š !…”
mentioning
confidence: 99%