Adaptive IRE1 Signaling Elicits T Cell Metabolic Remodeling and Tumor Control
Brian P. Riesenberg,
Evelyn J. Gandy,
Andrew S. Kennedy
et al.
Abstract:SummaryThe efficacy of cancer immunotherapies is limited by the metabolic instability of the tumor microenvironment (TME) that disables T cell antitumor immunity. Metabolic imbalances within the TME are sensed and responded to by stress sensors of the endoplasmic reticulum (ER) unfolded protein response (UPR). The UPR comprises three integrated signaling pathways harboring both adaptive and deleterious phases based on the extent and duration of cell stress. Here, we elucidate the differential contributions of … Show more
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