Adaptive fuzzy control of drug delivery in cancer treatment using combination of chemotherapy and antiangiogenic therapy

Abstract

This paper introduces the adaptive fuzzy control scheme as a promising control technique for cancer treatment from a theoretical point of view. A mathematical model describing the dynamics of tumor growth under the drug interventions of chemotherapy and antiangiogenic therapy is considered. The model incorporates the effects of normal cells, cancer cells, and endothelial cells. Then, the control goals in cancer treatment are discussed and the desired trajectory for a typical patient is derived using the optimal control theory. Since the dynamic model of tumor growth is not accurate and also varies from patient to patient, an adaptive fuzzy controller is designed to make the outputs of the dynamic model track the desired trajectory. The proposed control system is model–independent and identifies the dynamic model of tumor growth over time. The performance of the designed controller is assessed by several numerical simulations. Finally, a hardware–in–the–loop simulation is conducted to validate the results.