New generation of medical treatment has been supported by computerized processes. Signals recorded from the human body provide valuable information about the biological activities of body organs. The organs' characteristic topologies with temporal and spectral, properties, can be correlated with a normal or pathological function. In response to dynamic changes in the behavior of those organs, the signals exhibit timevarying, non-stationary responses. The signals are always contaminated by a drift and interference caused by several bioelectric phenomena, or by various types of noise, such as intrinsic noise from the recorder and noise from electrode-skin contact. In this paper we utilize Adaptive Filters for noise cancellation and analysis ECG signals.