Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis

Ko, Jae-Ki; Cho, Chi-Hin; Lam, Shiu‐Kum

doi:10.3748/wjg.v10.i17.2503

Cited by 28 publications

(20 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This protective mechanism, evoked by mild irritants, such as low doses of ethanol, seems to involve increased production of nitric oxide primarily from the constitutive isoforms of NOS and a resultant increase in blood flow [32,33]. Therefore, we may conclude that the ulcerogenic activity of NSAIDs could be attenuated in stomach, despite an inhibition of PGE 2 , by the development of cytoprotective events.…”

Section: Controlmentioning

confidence: 95%

Effect of Different Cyclooxygenase Inhibitors on Gastric Adaptive Cytoprotection Induced by 20% Ethanol

et al. 2007

View full text Add to dashboard Cite

In this study, we evaluated the effect of two different dosages of therapeutically prescribed nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen, diclofenac, nimesulide, meloxicam, and celecoxib (ED80 for COX-1 and COX-2) on normal gastric mucosa and mucosa, previously exposed to 20% ethanol. At COX-2-inhibiting dosages, the NSAIDs tested were nonulcerogenic, and the same response profile was observed in "adapted" stomachs. Interestingly, low doses of nimesulide and celecoxib increase the levels of Prostaglandin E(2) and COX-2, and protect against subsequent 100% ethanol exposition, suggesting that these drugs may act as "mild irritants" to gastric mucosa. The ulcerogenic response to NSAIDs was prevented by the previous 20% ethanol exposition, probably the result of nitric oxide synthesis, because PGE(2) levels in gastric mucosa were reduced by these agents and a concomitant nitric oxide blockade reversed this protection.

show abstract

Section: Controlmentioning

confidence: 95%

Effect of Different Cyclooxygenase Inhibitors on Gastric Adaptive Cytoprotection Induced by 20% Ethanol

et al. 2007

View full text Add to dashboard Cite

show abstract

“…This phenomenon has been termed "adaptive cytoprotection," and it is thought to be mediated by increased production of endogenous gastric PGs by a mild irritant [5,28]. In order to study the protective mechanism of rice extract, we evaluated the effect of rice extract on gastroprotective factors including PGE 2 .…”

Section: Discussionmentioning

confidence: 99%

“…These factors include systemic stresses and the application of local irritants [1][2][3]. Alcohol consumption, for example, can produce acute hemorrhagic gastric erosions, and excessive ingestion can result in gastritis characterized by mucosal edema, subepitherial hemorrhages, cellular exfoliation, and inflammatory cell infiltration [4,5]. Ethanol reduces levels of nonprotein sulfhydryl groups, such as glutathione, thereby increasing reactive oxygen species (ROS) that have ulcerogenic activity.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of a Novel Rice Extract Against Ethanol-Induced Gastric Mucosal Injury in Rat

et al. 2007

View full text Add to dashboard Cite

The aim of this study was to investigate the protective action of rice extract on ethanol-induced mucosal damage in vivo and wound healing of epithelial cells in vitro. Also, the effect of rice extract on gastric mucosal prostaglandin E(2) level, HSP72 expression, gastric acid secretion, and contribution of vanilloid receptor-mediated action was studied. In addition, using cultured gastric mucosal cells (RGM-1), the effect of rice extract on cytoprotection and wound healing of epithelial cells was evaluated. Rice extract significantly reduced gastric mucosal damage produced by ethanol in vivo, and heat treatment (80 degrees C, 3 min) of this agent did not alter its protective effect. Rice extract also protected RGM-1 from ethanol-induced damage in a dose-dependent manner. Rice extract accelerated wound healing of gastric epithelial cells. Our results demonstrate that rice extract could be an alternative ulcer treatment that provides cytoprotection and enhancement of wound healing not dependent on acid secretion, prostaglandin E(2) level, HSP72 expression, or vanilloid receptors.

show abstract

“…12,13 Absolute ethanol is highly corrosive to the gastric mucosa and its mechanism of action on rat gastric mucosa involves superficial necrosis of gastric mucosa and release of histamine and leukotriene C4 as tissuederived mediators. Ethanol-induced gastric ulcers have been widely used for the experimental evaluation of antiulcer activities; this method of inducing gastric lesions is a rapid and convenient way of screening cytoprotective drug as anti-ulcer potency.…”

Section: Discussionmentioning

confidence: 99%

Preliminary study on antiulcer effect of agomelatine and its potentiation with pyridoxine

Shukla

Porwal

Roy³

et al. 2017

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Background: Agomelatine is a synthetic analogue of melatonin and a potent agonist of melatonin receptors. Agomelatine has Hepatoprotective as well as antioxidant activity. The aim of study was to evaluate the antiulcer activity of Agomelatine and its potentiation through the pyridoxine on ethanol induced gastric ulcer in rats.Methods: Thirty number of rats were divided in to five groups contro, standard, Agomelatine low dose, Agomelatine high dose and Agomelatine with Pyridoxine groups. Ethanol was used to induced gastric ulcer in rats. ulcer index and also the other biochemical parameters like free Acidity, total Acidity, gastric pH, volume of gastric juice was determined. Statistically analysis was done by ANOVA P value less than 0.05 was considered Statistically significant.Results: In the present study, an attempt has been made to investigate the gastric antisecretory, antiulcer and cytoprotective properties of agomelatine. The results are statistically significant by ANOVA test. Ranitidine showed a statistically significant decrease in the volume of gastric juice by free acidity and total acidity. when compared to control. Agomelatine shows a showed similar response to the volume of gastric juice. A significant difference in pH was observed between the agomelatine-treated, agomelatine with pyridoxine treated group and the control groups.Conclusions: Pretreated rats with Agomelatine (40mg/kg) showed protective effect against ethanol induce gastric ulcer. Agomelatine (40mg/kg) showed the ameliorative effect with Pyridoxine (0.3mg/kg), on gastric ulcer.

show abstract

Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis

Cited by 28 publications

References 35 publications

Effect of Different Cyclooxygenase Inhibitors on Gastric Adaptive Cytoprotection Induced by 20% Ethanol

Effect of Different Cyclooxygenase Inhibitors on Gastric Adaptive Cytoprotection Induced by 20% Ethanol

Protective Effect of a Novel Rice Extract Against Ethanol-Induced Gastric Mucosal Injury in Rat

Preliminary study on antiulcer effect of agomelatine and its potentiation with pyridoxine

Contact Info

Product

Resources

About