This article presents technology that extends the concept of end-point control of a flexible-link robot arm to handle payloads with unknown internal dynamics. The approach is based on merging high-performance control with an innovative identification algorithm in a self-tuning regulator framework. Payload dynamics are identified in real time using recently developed subspace fitting techniques. Sufficient excitation issues are addressed. End-point feedback controllers are formulated using frequency-weighted linear quadratic gaussian design methods.Experimental results demonstrating precision control of a very flexible single-link robot arm with unknown dynamic payloads are presented.