Standard MRI cine exams for the study of cardiac function are segmented over several heartbeats and thus require a breathhold to minimize breathing motion artifacts, which is a current limitation of this approach. The purpose of this study was to develop a method for the measurement and correction of respiratory motion that is compatible with cine imaging. Realtime images were used to measure the respiratory motion of heart, to allow translations, rotations, and shears to be measured and corrected in the k-space domain prior to a final gated-segmented reconstruction, using the same data for both purposes. A method for data rejection to address the effects of through-plane motion and complex deformations is described (respiratory gating). A radial k-space trajectory was used in this study to allow direct reconstruction of undersampled real-time images, although the techniques presented are applicable with Cartesian k-space trajectories. Corrected and uncorrected free-breathing gated-segmented images acquired over 18 sec were compared to the current standard breath-hold Cartesian images using both quantitative sharpness profiles (mm ؊1 )
Key words: cardiac MRI; free breathing; respiratory gating; cine MRIThe requirement for a patient breath-hold in studies of cardiac function is a current limitation of cardiovascular MRI. Standard cine exams are segmented over several heartbeats so a breath-hold is required to minimize breathing motion artifacts. The breath-hold constraint reduces patient comfort, can yield poor image quality due to inconsistent breath-holding, and limits the patient population to those able to sustain repeated breath-holds. Pediatric patients in particular cannot hold their breath on demand and/or may be anesthetized for imaging studies. Also, breath-holding will always reduce the acquisition duty cycle due to the need for recovery between breathholds. While conventional navigator approaches use the diaphragm or the heart itself for respiratory gating of enddiastolic images, a standard approach for coronary artery imaging (1-5), these methods in general are not appropriate for cine imaging experiments, which require full coverage of the cardiac cycle. Specifically, the time required to excite the navigator tissue and then establish steady-state conditions for the primary cine imaging experiment precludes full cycle imaging. Also, both respiratory position and cardiac phase vary continuously over time, so continuous monitoring of respiratory motion is desirable.The goal of this study was to develop respiratory motion monitoring and correction for cine imaging without interfering with the primary gated-segmented acquisition. In order to combine these secondary monitoring and primary imaging features, this study expands on the common theme of using MRI data for dual purposes. This selfnavigation approach has been used extensively in MRI, targeting the brain and most often the coronary arteries (6 -11). As mentioned above, these approaches offer only single-cardiac-phase images and the methods develo...