2024
DOI: 10.1101/2024.03.06.583766
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Adaptive admixture atACKR1(the Duffy locus) may have shapedPlasmodium vivaxprevalence in Oman

Paige E. Haffener,
Arwa Z. Al-Riyami,
Shoaib Al-Zadjali
et al.

Abstract: Malaria in humans is largely caused by two divergent species of Plasmodium parasites, P. vivax and P. falciparum, both of which have driven the spread of protective alleles in human populations. Notably, an erythrocyte-specific Duffy null allele (FyES) confers resistance to P. vivax malaria and has been identified as a target of strong, recent positive selection in multiple African admixed populations. Here, we evaluate evidence for selection via adaptive admixture in Oman, where compared to neighboring countr… Show more

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“…For instance, the RHD*𝜓 indel, erythrocyte-specific null allele in the Duffy blood group, and GYP.He(P2) alleles are most common to African populations. These alleles were found in multiple Omani blood donors from this dataset and their prevalence in the population is consistent with what is known about the shared genetic ancestry of the Omanis with East African populations 19,59,60 . Overall, this study emphasizes the necessity to increase population representation in genotype databases and indicates that whole genome sequencing paired with serology is a valuable approach for doing so in transfusion practice.…”
Section: Discussionsupporting
confidence: 88%
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“…For instance, the RHD*𝜓 indel, erythrocyte-specific null allele in the Duffy blood group, and GYP.He(P2) alleles are most common to African populations. These alleles were found in multiple Omani blood donors from this dataset and their prevalence in the population is consistent with what is known about the shared genetic ancestry of the Omanis with East African populations 19,59,60 . Overall, this study emphasizes the necessity to increase population representation in genotype databases and indicates that whole genome sequencing paired with serology is a valuable approach for doing so in transfusion practice.…”
Section: Discussionsupporting
confidence: 88%
“…The allele frequency (AF) of RHD *ψ in the Omanis is similar to the AF in African/African American population in gnomADv4.0 29 (Figure 1), with AFs of 0.0376 and 0.0389, respectively. This is higher than the gnomADv4.0 Middle Eastern population (AF=0.0022), indicating heterogeneity across the Middle East, likely due to variation in African ancestry 19 .…”
Section: Resultsmentioning
confidence: 70%
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