Adapting dose–response methodology to improve clinical trial design for psychotherapies
Robyn Sysko,
Katherine Holland,
Tom Hildebrandt
Abstract:ObjectiveConventional randomized controlled trials (RCTs) have long served as the foundation of research in clinical psychology; however, most treatments for eating disorders show only modest effects on reduction of symptoms and maintenance of long‐term remission. New options for psychotherapy treatment development research, beyond continuing to pursue additive or subpopulation approaches, are needed.MethodsOne option is to apply dose–response designs, which are commonplace in studies of pharmacology, toxicolo… Show more
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