Adapting a Combination of Intrinsic and Extrinsic Cellular Factors to Generate an Improved Model of Tumor Exposure and Sensitivity to Chloroquine Derivatives
Abstract:In cancer clinical trials hydroxychloroquine (HCQ) is the only approved autophagy inhibitor for use in treatment. Pharmacokinetic data from clinical trials comparing tumor vs. blood concentrations of HCQ suggest that there is a significant disconnect between drug levels within these compartments [Barnard RA, Wittenburg LA, Amaravadi RK, Gustafson DL, Thorburn A, Thamm DH (2014) “Phase I Clinical Trial and Pharmacodynamic Evaluation of Combination Hydroxychloroquine and Doxorubicin Treatment in Pet Dogs Treated… Show more
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