Adapted Moderate Training Exercise Decreases the Expression of Ngal in the Rat Kidney: An Immunohistochemical Study

Rosa, Michelino Di; Castrogiovanni, Paola; Trovato, Francesca M.; Malatino, Lorenzo; Ravalli, Silvia; Imbesi, Rosa; Szychlinska, Marta Anna; Musumeci, Giuseppe

doi:10.3390/app9061041

Cited by 3 publications

(1 citation statement)

References 57 publications

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“…Twenty-four healthy 3-month-old male Wistar Outbred Rats were randomly divided into two groups, with 12 rats per group: sedentary rats (Group 1, sedentary) and rats undergoing moderate exercise on the treadmill (Group 2, PA). The programming of moderate PA follows the moderate physical training protocol for rats previously described by Di Rosa et al [52]. In particular, Group 2 performed 12-week running training.…”

Section: Experimental Designmentioning

confidence: 99%

Moderate Physical Activity Increases the Expression of ADNP in Rat Brain

Maugeri,

D’Amico,

Federico

et al. 2024

IJMS

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Activity-dependent neuroprotective protein (ADNP) is a neuroprotective protein essential for embryonic development, proper brain development, and neuronal plasticity. Its mutation causes the autism-like ADNP syndrome (also called the Helsmoortel-Van der Aa syndrome), characterized by neural developmental disorders and motor dysfunctions. Similar to the ADNP syndrome, the ADNP haploinsufficient mouse shows low synapse density, leading to motor and cognitive ability delays. Moderate physical activity (PA) has several neuroprotective and cognitive benefits, promoting neuronal survival, differentiation, neurogenesis, and plasticity. Until now, no study has investigated the effect of moderate exercise on ADNP expression and distribution in the rat brain. The aim of the current investigation was to study the effects of moderate exercise on the ADNP expression and neuronal activation measured by the microtubule protein β-Tubulin III. In pursuit of this objective, twenty-four rats were selected and evenly distributed into two categories: sedentary control rats and rats exposed to moderate physical activity on a treadmill over a span of 12 weeks. Our results showed that moderate PA increases the expression of ADNP and β-Tubulin III in the dentate gyrus (DG) hippocampal region and cerebellum. Moreover, we found a co-localization of ADNP and β-Tubulin III in both DG and cerebellum, suggesting a direct association of ADNP with adult neuronal activation induced by moderate PA.

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Section: Experimental Designmentioning

confidence: 99%

Moderate Physical Activity Increases the Expression of ADNP in Rat Brain

Maugeri,

D’Amico,

Federico

et al. 2024

IJMS

Self Cite

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Assessment of acute aerobic exercise in the morning versus evening on asprosin, spexin, lipocalin-2, and insulin level in overweight/obese versus normal weight adult men

Saygın

Turkcu

2020

Chronobiology International

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Studies of High Molybdenum-Induced Copper Deprivation in P. przewalskii on the Qinghai Lake Pasture in China

et al. 2021

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The Przewalski’s Gazelles (P. przewalskii) are affected by disorders that are characterized by deprived appetites, pica, emaciation and dyskinesia. The purpose of this study was to investigate the possibility of high molybdenum (Mo) in forage leading to copper (Cu) deprivation. The mineral contents in forage, soil, and samples of hair and blood from affected ranges were compared to healthy pasture. Blood parameters were also determined. Our results showed that the mean content of Mo in forage and soil in studied pasture was 5.17 and 4.17 μg/g, respectively. The Cu to Mo ratio in forage from affected and healthy areas was 1.26 and 5.89 μg/g, respectively. The Cu concentrations in hair and blood from gazelles in affected pasture were extremely lower (p < 0.01) than those in unaffected animals. The Mo contents in hair were higher (p < 0.01) than those in unaffected gazelles. The levels of Hb, RBC, PCV, MCV, and MCH in unaffected gazelles were significantly lower (p < 0.01) than those in unaffected gazelles. The levels of TP, ALB and GLB in blood were significantly lower (p < 0.01) than those in unaffected gazelles, while the levels of AST, LDH, CPK and ALP in serum were significantly higher (p < 0.01) than those in unaffected gazelles. The activities in serum T-AOC, SOD, GSH-Px, and CAT in affected gazelles were extremely lower (p < 0.01) than those in unaffected gazelles, while MDA was significantly higher (p < 0.01) than that in unaffected gazelles. Supplementation in copper sulphate (CuSO4) has prevented and cured this disorder. In summary, high molybdenum in feed and soil may lead to secondary Cu deficiency in gazelles, which can be alleviated by supplement of copper sulfate.

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Adapted Moderate Training Exercise Decreases the Expression of Ngal in the Rat Kidney: An Immunohistochemical Study

Cited by 3 publications

References 57 publications

Moderate Physical Activity Increases the Expression of ADNP in Rat Brain

Moderate Physical Activity Increases the Expression of ADNP in Rat Brain

Assessment of acute aerobic exercise in the morning versus evening on asprosin, spexin, lipocalin-2, and insulin level in overweight/obese versus normal weight adult men

Studies of High Molybdenum-Induced Copper Deprivation in P. przewalskii on the Qinghai Lake Pasture in China

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