ADAPTED EVIDENCE-BASED CLINICAL GUIDELINES: BRONCHIAL ASTHMA(Part 1)

Feshchenko, Y. I.; Iashyna, L. O.; Бойко, Дмитро Миколайович; Gavrysiuk, V. K.; Krakhmalova, Olena; Матюха, Л. Ф.; Mostovoy, Yu. M.; Перцева, Т. О.; Polianska, М. О.; Rekalova, О. M.; Ostrovsky, M. M.; Зайков, С. В.; Konopkina, Lyudmyla; Константинович, Т. В.

doi:10.31655/2307-3373-2020-2-5-26

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Conflict situations during pregnancy, the threat of termination, acute and chronic diseases accompanied by fetal hypoxia are observed in 70-85% of mothers with BA. Hypoxia leads to dysmetabolic processes in the central nervous system (CNS) and dysregulatory disorders of the cortical-subcortical and spinal structures of the brain that regulate the respiratory complex, disrupting neurogenic regulation of bronchial smooth muscle tone and damaging the ciliated epithelium [1,3,4,10].…”

Section: Introductionmentioning

confidence: 99%

Autoimune component in the development of celebrovascular insufficiency in children with bronchial asthma

2021

Actual Problems of Modern Medicine

View full text Add to dashboard Cite

Bronchial asthma (BA) remains one of the most serious diseases of our time. A number of studies have shown that this disease in a number of cases, especially with the threat of termination of pregnancy, acute and chronic diseases of mothers, accompanied by fetal hypoxia, originates in the ante- and postnatal period. In general, taking into account the peculiarities of the cellular tissue organization of the brain and cerebrovascular blood supply, prolonged hypoxic lesions increase the activity of the hypothalamic-diencephalic structures and the cerebral cortex. The existing respiratory disorders lead to hemodynamic and metabolic disorders of cerebral structures, emotional sphere and autonomic regulation. However, this issue in childhood requires further study. The aim is to study autoimmune processes in the pathogenesis of cerebrovascular insufficiency in children with BA. Materials and methods. We examined 121 patients with asthma aged 5 to 15 years in the period of exacerbation. To study the role of the autoimmune component in the development of cerebrovascular insufficiency and its relationship with the autoimmune process in the bronchopulmonary system in AD in children, we used a method for the quantitative determination of autoantibodies to lipopolysaccharide antigens (LA) of cerebral vessels and topographic structures of the brain, as well as to homologous LA bronchi and lung tissue. The results of the studies have shown that the first signs of cerebral hemodynamic disturbance are recorded already in patients with mild disease and are aggravated depending on the severity of BA. Conclusions. The most characteristic changes are an increase in the tone of small and medium vessels and impaired cerebral venous circulation. It was also found that the levels of autoantibodies to lipopolysaccharide antigens of cerebral vessels and cellular tissue structures of the brain correlate with an increase in the level of autoantibodies to lipopolysaccharide antigens of the trachea, bronchi and lung tissue and reflect the severity of AD in children.

show abstract

Section: Introductionmentioning

confidence: 99%

Autoimune component in the development of celebrovascular insufficiency in children with bronchial asthma

2021

Actual Problems of Modern Medicine

View full text Add to dashboard Cite

show abstract

“…Бронхіальна астма (БА) є розповсюдженим захворюванням органів дихання, але має досить значний діапазон поширеності в різних країнах світу, коливаючись від 0,2% у Китаї до 21% у Австралії, що зумовлено генетичними, етнічними особливостями, станом навколишнього середовища, доступністю, якістю надання медичної допомоги та іншими чинниками [1,2,3].…”

unclassified

“…За даними офіційної статистики в Україні поширеність діагностованої лікарем БА знаходиться на рівні 1,25 %. За даними міжнародного епідеміологічного опитування CORE щодо симптомів БА, таких як свистяче, утруднене дихання, стиснення у грудях, кашель, що виникають епізодично поширеність захворювання складає 7,4 %, тобто майже у шість разів більше [2,3].…”

unclassified

Asthma From the Point of View of General Ractitioner and Patient

Demchuk¹

2021

UPJ

View full text Add to dashboard Cite

The significance of the distribution of the indicators of humoral and cell immunity and their role in the pathogenesis of bronchial asthma in children with the position of system analysis

Chernuskyi

Попов

Letiaho

et al. 2021

The Journal of v. N. Karazin Kharkiv National University, Series "Medicine"

View full text Add to dashboard Cite

Bronchial asthma is one of the common diseases in children of different ages. In recent years, around the world, including in Ukraine, there is a trend towards its sustainable growth. To date, there are no methods of systemic immunodiagnostics that would allow with high diagnostic accuracy to identify clinical forms and severity of asthma, which would allow more fully reveal the pathogenetic mechanisms and individualize approaches to the treatment of asthma in children. The aim of this work was to study the hierarchy of immunological parameters in the pathogenetic matrix, which will determine the features of clinical forms and severity of asthma in children on the basis of systematic analysis. A comprehensive clinical and immunological examination of 176 children with asthma aged 6 to 15 years. To detect the autoimmune component used lipopolysaccharide antigens obtained from homologous cell-tissue structures of the trachea, bronchi and lung tissue from sectional samples of the bronchopulmonary system from accidentally killed children with group I (0) blood 2–4 hours after death. The level of autoantibodies to lipopolysaccharide antigens of the bronchopulmonary system was determined by quantifying the autoantibody index – Qφ. As a result of the study for the first time to improve the diagnosis and differentiation of clinical forms and severity of asthma from the standpoint of system analysis was developed immunodiagnostic complex, which took into account the degree of deviation from the norm values (Student's t-test, t = 1.96) and their distribution in pathogenetic matrix. This approach to ranking the positions of immunological parameters allowed to determine the features of humoral and cellular immunity, the process of apoptosis of cell-tissue structures of the bronchopulmonary system and the autoimmune component in the pathogenesis of asthma in children, which opens approaches to individualization of pathogenetic therapy.

show abstract

ADAPTED EVIDENCE-BASED CLINICAL GUIDELINES: BRONCHIAL ASTHMA(Part 1)

Cited by 3 publications

References 0 publications

Autoimune component in the development of celebrovascular insufficiency in children with bronchial asthma

Autoimune component in the development of celebrovascular insufficiency in children with bronchial asthma

Asthma From the Point of View of General Ractitioner and Patient

The significance of the distribution of the indicators of humoral and cell immunity and their role in the pathogenesis of bronchial asthma in children with the position of system analysis

Contact Info

Product

Resources

About