Adaptative processes, control measures, genetic background, and resilience of malaria vectors and environmental changes in the Amazon region

Tadei, Wanderli Pedro; Rodrigues, Iléa Brandão; Rafael, Míriam Silva; Sampaio, Raquel T M; Mesquita, Hugo; Pinheiro, Valéria Cristina Soares; Zequi, João Antonio Cyrino; Roque, Rosemary Aparecida; Santos, Joselita Maria Mendes dos

doi:10.1007/s10750-016-2960-y

Cited by 28 publications

(33 citation statements)

References 66 publications

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“…is an alternative to conventional control measures against Anopheles larvae 96,97 . Bti is a bacterium that produces proteins, such as δ-endotoxins, which are toxic to larvae of several insects 98,99 .…”

Section: /10mentioning

confidence: 99%

Current vector control challenges in the fight against malaria in Brazil

Baía-da-Silva

Brito-Sousa

Rodovalho

et al. 2019

Rev. Soc. Bras. Med. Trop.

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In Brazil, malaria is an important public health problem first reported in 1560. Historically, fluctuations in malaria cases in Brazil are attributed to waves of economic development; construction of railroads, highways, and hydroelectric dams; and population displacement and land occupation policies. Vector control measures have been widely used with an important role in reducing malaria cases. In this review article, we reviewed the vector control measures established in the Brazilian territory and aspects associated with such measures for malaria. Although some vector control measures are routinely used in Brazil, many entomological and effectiveness information still need better evidence in endemic areas where Plasmodium vivax predominates. Herein, we outlined some of the needs and priorities for future research: a) update of the cartography of malaria vectors in Brazil, adding molecular techniques for the correct identification of species and complexes of species; b) evaluation of vector competence of anophelines in Brazil; c) strengthening of local entomology teams to perform vector control measures and interpret results; d) evaluation of vector control measures, especially use of insecticide-treated nets and long-lasting insecticidal nets, estimating their effectiveness, cost-benefit, and population acceptance; e) establishment of colonies of malaria vectors in Brazil, i.e., Anopheles darlingi, to understand parasite-vector interactions better; f) study of new vector control strategies with impacts on non-endophilic vectors; g) estimation of the impact of insecticide resistance in different geographical areas; and h) identification of the relative contribution of natural and artificial breeding sites in different epidemiological contexts for transmission.

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Section: /10mentioning

confidence: 99%

Current vector control challenges in the fight against malaria in Brazil

Baía-da-Silva

Brito-Sousa

Rodovalho

et al. 2019

Rev. Soc. Bras. Med. Trop.

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“…On one hand, the species is characterized by a high level of anthropophily and endophagy in relation to other mosquito species of the Amazon region. On the other hand, A. darlingi is the malaria transmitting species the most favored by environmental changes resulting from human activities such as occupation of urban and peri-urban spaces in an uncontrolled manner; the construction of hydroelectric power plants, irrigation projects, and fishponds; the exploitation of fossil fuels, minerals, and natural gas; forest fires; deforestation; and road construction [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, molecular docking studies, and larvicidal activity evaluation of new fluorinated neonicotinoids against Anopheles darlingi larvae

et al. 2020

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Anopheles darlingi is the main vector of malaria in Brazil, characterized by a high level of anthropophilia and endophagy. Imidacloprid, thiacloprid, and acetamiprid are the most widespread insecticides of the neonicotinoid group. However, they produce adverse effects on the non-target insects. Flupyradifurone has been marketed as an alternative to non-fluorinated neonicotinoids. Neonicotinoids containing trifluoroacethyl substituent reveal increased insecticidal activity due to higher hydrophobicity and metabolic stability. We synthesized novel neonicotinoid insecticides containing fluorinated acceptor groups and their interactions were estimated with the nicotinic acetylcholine receptor (nAChR) binding site by molecular docking studies, to evaluate their larvicidal activity against A. darlingi, and to assess their outdoor photodegradation behavior. New neonicotinoid analogues were prepared and characterized by NMR and mass-spectrometry. The synthesized molecules were modelled by time-dependent density functional theory and analyzed, their interaction with nAChR was investigated by molecular docking. Their insecticide activity was tested on Anopheles larvae collected in suburban area of Manaus, Brazil. Four new fluorinated neonicotinoid analogs were prepared and tested against 3 rd instars larvae of A. darlingi showing high larvicidal activity. Docking studies reveal binding modes of the synthesized compounds and suggest that their insecticidal potency is governed by specific interactions with the receptor binding site and enhanced lipophilicity. 2-Chloro-5-(2-trifluoromethyl-pyrrolidin-1ylmethyl)pyridine 5 showed fast degradation in water maintaining high larvicidal activity. All obtained substances possessed high larvicidal activity in low concentrations in 48 hours of exposure, compared to commercial flupyradifurone. Such activity is connected to a unique binding pattern of the synthesized compounds to insect's nAChR and to their enhanced bioavailability owing to introduction of fluorinated amino-moieties. Therefore, the compounds in question have a high potential for application as control agents for insects transmitting tropical diseases, and they will be less persistent in the environment.

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“…These changes contribute to increased mosquito populations, especially of An. darlingi in settled areas near forest edges in the Amazon (Barros and Honório , Tadei et al ). Moreover, a high density of An.…”

Section: Introductionmentioning

confidence: 99%

Effect of acute and chronic exposure to ammonia on different larval instars of Anopheles darlingi (Diptera: Culicidae)

Dias

Rodrigues

Silva

2019

Journal of Vector Ecology

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Anopheles darlingi (Diptera: Culicidae) is the most important vector of malaria in South America and has already been found in peri‐urban areas that commonly contain toxic nitrogenous compounds, such as ammonia. The adaptation of mosquitoes to polluted breeding sites can increase their distribution and affect the dynamics of vector‐borne diseases such as malaria. Therefore, the present study investigated the tolerance of larval instars of An. darlingi to ammonia under acute and chronic exposure conditions. Anopheles darlingi larval mortality, development time, and pupal and adult production using larvae of the 1st (L1) and 3rd (L3) instar were assessed as both acute and chronic effects of exposure to different concentrations of ammonia. Lethal concentrations (LCs) for L1 larvae were lower than LCs for L3 larvae. In general, higher ammonia concentrations caused an increase in larval mortality, especially in chronically exposed L1 larvae. The larval development time in L1 and L3 was longer with chronic treatment and decreased with increasing concentrations of ammonia. The number of pupae was very low for acutely exposed L1 and L3 larvae. Likewise, the probability of adult production decreased with increasing ammonia concentrations. This is the first report on the tolerance of An. darlingi to pollutants.

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Adaptative processes, control measures, genetic background, and resilience of malaria vectors and environmental changes in the Amazon region

Cited by 28 publications

References 66 publications

Current vector control challenges in the fight against malaria in Brazil

Current vector control challenges in the fight against malaria in Brazil

Synthesis, molecular docking studies, and larvicidal activity evaluation of new fluorinated neonicotinoids against Anopheles darlingi larvae

Effect of acute and chronic exposure to ammonia on different larval instars of Anopheles darlingi (Diptera: Culicidae)

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