Adaptations in Skeletal Muscle Disuse or Decreased-Use Atrophy

Edgerton, V. Reggie; Roy, Roland R.; Allen, David L.; Monti, Ryan J.

doi:10.1097/00002060-200211001-00014

Cited by 96 publications

(81 citation statements)

References 146 publications

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“…In experimental models of hindlimb immobilisation and unloading the effects of muscle disuse atrophy on muscle morphology and muscle mechanics are variable and depend upon muscle type and fibre type (Ariano et al, 1973;Booth and Kelso, 1973;Edgerton et al, 2002;Peter et al, 1972;Trappe et al, 2004;Witzmann et al, 1982). Most muscles are composed of a heterogenous mixture of fibre types, although there are exceptions.…”

Section: Introductionmentioning

confidence: 99%

Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivatingCyclorana alboguttata(Günther 1867)

Symonds

James

Franklin

2007

Journal of Experimental Biology

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SUMMARY Prolonged immobilisation or unloading of skeletal muscle causes muscle disuse atrophy, which is characterised by a reduction in muscle cross-sectional area and compromised locomotory function. Animals that enter seasonal dormancy, such as hibernators and aestivators, provide an interesting model for investigating atrophy associated with disuse. Previous research on the amphibian aestivator Cyclorana alboguttata (Günther 1867)demonstrated an absence of muscle disuse atrophy after 3 months of aestivation, as measured by gastrocnemius muscle contractile properties and locomotor performance. In this study, we aimed to investigate the effect of aestivation on iliofibularis and sartorius muscle morphology and contractile function of C. alboguttata over a longer, more ecologically relevant time-frame of 9 months. We found that whole muscle mass, muscle cross-sectional area, fibre number and proportions of fibre types remained unchanged after prolonged disuse. There was a significant reduction in iliofibularis fibre cross-sectional area (declined by 36% for oxidative fibre area and 39% for glycolytic fibre area) and sartorius fibre density (declined by 44%). Prolonged aestivation had little effect on the isometric properties of the skeletal muscle of C. alboguttata. There was a significant reduction in the isometric contraction times of the relatively slow-twitch iliofibularis muscle, suggesting that the muscle was becoming slower after 9 months of aestivation (time to peak twitch increased by 25%, time from peak twitch to half relaxation increased by 34% and time from last stimulus to half tetanus relation increased by 20%). However, the results of the work-loop analysis clearly demonstrate that, despite changes to muscle morphology and isometric kinetics, the overall contractile performance and power output levels of muscles from 9-month aestivating C. alboguttata are maintained at control levels.

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Section: Introductionmentioning

confidence: 99%

Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivatingCyclorana alboguttata(Günther 1867)

Symonds

James

Franklin

2007

Journal of Experimental Biology

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“…It contracts eccentrically during walking down a slope. Decreased levels of physical activity [54][55][56], weightbearing status [56][57][58], and immobilization [59][60][61] can lead to progressive atrophy. Several factors including decreased protein synthesis [62][63][64], increased levels of plasma cortisol [65], arthrogenic inhibition [66,67], and altered afferent inflow [66] may be responsible for atrophy after trauma or in periods of prolonged muscular disuse.…”

Section: Causes Of Quadriceps Weaknessmentioning

confidence: 99%

Prehabilitation: The Void in the Management of Anterior Cruciate Ligament Injuries—A Clinical Review

Shaarani

Moyna

Moran

et al. 2012

ISRN Rehabilitation

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The rehabilitation of patients undergoing anterior cruciate ligament (ACL) reconstruction requires symmetry in bilateral quadriceps strength and adequate proprioception capabilities prior to return to preoperative level of activity or sport. This is the limiting factor and can delay the time that patients can return to play. There is little literature on pre-operative physiotherapy or prehabilitation of patient with ACL injury. This paper discusses the anatomy, biomechanics, surgical decision making, and the current knowledge of preoperative training or "prehabilitation" in patients awaiting ACL reconstruction.

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“…Skeletal muscle atrophy is induced by various factors, such as joint immobilization, hindlimb unloading, spaceflight, denervation, tenotomy, and ageing (Ohira, 2000;Edgerton et al, 2002). Therefore, there might be some differences among these factors in the mechanism of muscle atrophy; when the mechanism of the muscle atrophy is different, the manner of recovery might also differ.…”

Section: Experimental Designmentioning

confidence: 99%

Influence of fixed muscle length and contractile properties on atrophy and subsequent recovery in the rat soleus and plantaris muscles

Fujita

Arakawa

Matsubara

et al. 2009

Archives of Histology and Cytology

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Adaptations in Skeletal Muscle Disuse or Decreased-Use Atrophy

Cited by 96 publications

References 146 publications

Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivatingCyclorana alboguttata(Günther 1867)

Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivatingCyclorana alboguttata(Günther 1867)

Prehabilitation: The Void in the Management of Anterior Cruciate Ligament Injuries—A Clinical Review

Influence of fixed muscle length and contractile properties on atrophy and subsequent recovery in the rat soleus and plantaris muscles

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