2018
DOI: 10.1186/s12864-018-4696-8
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Adaptations in energy metabolism and gene family expansions revealed by comparative transcriptomics of three Chagas disease triatomine vectors

Abstract: BackgroundChagas disease is a parasitic infection caused by Trypanosoma cruzi. It is an important public health problem affecting around seven to eight million people in the Americas. A large number of hematophagous triatomine insect species, occupying diverse natural and human-modified ecological niches transmit this disease. Triatomines are long-living hemipterans that have evolved to explode different habitats to associate with their vertebrate hosts. Understanding the molecular basis of the extreme physiol… Show more

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Cited by 13 publications
(30 citation statements)
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“…To estimate the proportion of the generated database that is homologous to R. prolixus (httpd://www.vectorbase.org/organisms/rhodnius-prolixus/cdc/rproc3;26), H. halys ( https://i5k.nal.usda.gov/Halyomorpha_halys ), and O. fasciatus ( https://data.nal.usda.gov/dataset/oncopeltus-fasciatus-genome-assembly-10 ) predicted proteomes, we used NCBI-BLASTX (–e 1.0E-05). Putative 1:1 orthologue identification among these datasets was done using the BLAST RBH strategy as described 80 . The orthologues shared by three or more species were calculated using a bash script to simplify this operation (bash script is provided in Supp.…”
Section: Methodsmentioning
confidence: 99%
“…To estimate the proportion of the generated database that is homologous to R. prolixus (httpd://www.vectorbase.org/organisms/rhodnius-prolixus/cdc/rproc3;26), H. halys ( https://i5k.nal.usda.gov/Halyomorpha_halys ), and O. fasciatus ( https://data.nal.usda.gov/dataset/oncopeltus-fasciatus-genome-assembly-10 ) predicted proteomes, we used NCBI-BLASTX (–e 1.0E-05). Putative 1:1 orthologue identification among these datasets was done using the BLAST RBH strategy as described 80 . The orthologues shared by three or more species were calculated using a bash script to simplify this operation (bash script is provided in Supp.…”
Section: Methodsmentioning
confidence: 99%
“…Previously, several works explored the relationship between gene families expansions and hematophagy [10,20,37,40], but they usually focused only in one species/ group or few gene families and they did not employ a statistical approach to model the evolution of gene families. Two exceptions are the works of Neafsey et al (2015) [9] and Thomas et al (2020) [41].…”
Section: Discussionmentioning
confidence: 99%
“…Although several strategies to infer convergent molecular evolution are being developed and used [17], few works aimed to study the convergence of gain and loss in gene copies number across distinct lineages [16]. For example, in insects, the expansion of some gene families has been linked to blood-feeding behavior, since the expression of extra copies of genes would help in blood digestion [18][19][20][21].…”
Section: Introductionmentioning
confidence: 99%
“…Driven by hunger, R. neglectus needs to search for a host to feed, which may explain the increased expression of the transcript for Csp-like (Figure 9A), a protein related to the ability to perceive chemical substances that are important for the insect, in feeding, reproduction, and survival, and has already been identified in several triatomine tissues (Ribeiro et al, 2014;Marchant et al, 2016;Martinez-Barnetche et al, 2018).…”
Section: Compensatory Mechanisms In Prolonged Fasting To Blood Availability: Base Expression In R Neglectus Sgs and Intmentioning
confidence: 99%