Adaptation to Myocardial Ischemia During Repeated Ventricular Pacing in Patients with Coronary Artery Disease

Ylitalo, Kari; Peuhkurinen, Keijo

doi:10.1080/14017430050142134

Scandinavian Cardiovascular Journal

2000

DOI: 10.1080/14017430050142134

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Adaptation to Myocardial Ischemia During Repeated Ventricular Pacing in Patients with Coronary Artery Disease

Kari Ylitalo

Keijo Peuhkurinen²

Abstract: Rapid ventricular pacing is able to induce adaptation to myocardial ischemia, but the exact mechanisms in this process remain to be elucidated.

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Cited by 2 publications

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Clinical Relevance of Ischemic Preconditioning

Ylitalo¹,

Peuhkurinen²

2001

Scandinavian Cardiovascular Journal

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The mechanisms of ischemic cell death and reperfusion injury in the myocardium and the ways to limit these have been under extensive research for decades. The discovery of the phenomenon of ischemic preconditioning, i.e. endogenous protection against ischemia-reperfusion injury obtained by one or more brief preceding episodes of ischemia, really boosted this research 15 years ago. Even though extensive research in experimental animals has provided data on the cellular mechanisms of ischemic preconditioning, such as adenosine receptor activation, opening of mitochondrial adenosine triphosphate (ATP)-sensitive potassium channels and production of endogenous protective stress proteins, direct clinical applications are still missing. The purpose of this study is to summarize the latest progress in solving the cellular and molecular mechanisms of the phenomenon, as well as the evidence for the existence of this phenomenon in humans and its clinical relevance.

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Clinical Relevance of Ischemic Preconditioning

Ylitalo¹,

Peuhkurinen²

2001

Scandinavian Cardiovascular Journal

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Role of caveolin-eNOS platform and mitochondrial ATP-sensitive potassium channel in abrogated cardioprotective effect of ischemic preconditioning in postmenopausal women

Goyal

Agrawal

Jain

et al. 2022

Braz. J. Pharm. Sci.

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Adaptation to Myocardial Ischemia During Repeated Ventricular Pacing in Patients with Coronary Artery Disease

Abstract: Rapid ventricular pacing is able to induce adaptation to myocardial ischemia, but the exact mechanisms in this process remain to be elucidated.

Cited by 2 publications

References 20 publications

Clinical Relevance of Ischemic Preconditioning

Clinical Relevance of Ischemic Preconditioning

Role of caveolin-eNOS platform and mitochondrial ATP-sensitive potassium channel in abrogated cardioprotective effect of ischemic preconditioning in postmenopausal women

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