Adaptation to Dosed Hypoxia-Hyperoxia as a Factor in the Improvement of Quality of Life for Elderly Patients with Cardiac Pathology

Глазачев, О. С.; Дудник, Е. Н.; Запара, М. А.; Samarceva, V G; Kofler, Walter

doi:10.1134/s2079057019040052

Cited by 3 publications

(27 citation statements)

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“…The inter-session density of the IHHE intervention (i.e. distribution of IHHE sessions across a distinct time interval with regard to recovery time in-between the IHHE sessions) was reported in the study from Glazachev et al [ 110 ] and Bestavashvili et al [ 112 ] (5 weekly IHHE sessions and 2 days of rest per week). In seven studies, [ 66 , 106 – 110 , 112 ] the patients’ individual reaction to a hypoxic stimulus was determined with a hypoxia test that was conducted prior to the IHHE intervention.…”

Section: Resultsmentioning

confidence: 99%

“…All reviewed studies [ 66 , 106 – 112 ] used IHHE. IHHE was performed in different populations, including geriatric patients [ 106 ], older patients with coronary arterial disease [ 107 , 110 ], young track and field athletes with overtraining syndrome [ 108 ], older cardiology outpatients [ 109 ], older patients with prediabetes [ 66 ], older patients with mild cognitive impairment [ 111 ], and patients with metabolic syndrome [ 112 ]. Detailed information about the number of participants, sex distribution, and participants’ characteristics (e.g.…”

Section: Resultsmentioning

confidence: 99%

“…(6) 12–13 at Borg scale and/or 64–75% of maximal heart rate (1) 0.11–0.12/0.30–0.33 (2) 5–7 cycles (3) 4–6 min/3 min (4) N.R. (5) Glazachev et al [ 110 ] (1) Randomized controlled trial (2) 2 groups [1] IHHE (normobaric IHHE) [2] Sham IHHE (simulated IHHE (normobaric normoxic air)) (1) Patients with chronic coronary artery disease and angina pectoris of functional class II–III (2) Overall: 36 (26/10) IHHE: 17 (N.R.) Sham IHHE: 19 (N.R.)…”

Section: Resultsmentioning

confidence: 99%

“…Five studies [ 66 , 106 , 109 , 110 , 112 ] were classified as randomized controlled trials, one study [ 107 ] as a non-randomized controlled trial, and two studies [ 108 , 111 ] were described as pilot studies. In seven studies [ 66 , 106 , 107 , 109 – 112 ], the IHHE intervention group was compared to at least one control group performing a sham IHHE.…”

Section: Resultsmentioning

confidence: 99%

“…The cycle duration for the hypoxia and hyperoxia periods ranged from 2 to 7 min and 1 to 6 min, respectively. Four studies [ 106 , 108 , 110 , 112 ] reported the total time taken for a single IHHE procedure with a minimum of 35 and a maximum of 50 min. Based on the number of cycles and the duration of the hypoxic and hyperoxic periods, it can be assumed that the entire training session lasted approximately 35–63 min [ 107 , 109 ] and 32 min [ 66 , 111 ] in the studies not reporting the total duration.…”

Section: Resultsmentioning

confidence: 99%

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Effects of Intermittent Hypoxia–Hyperoxia on Performance- and Health-Related Outcomes in Humans: A Systematic Review

et al. 2022

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Background Intermittent hypoxia applied at rest or in combination with exercise promotes multiple beneficial adaptations with regard to performance and health in humans. It was hypothesized that replacing normoxia by moderate hyperoxia can increase the adaptive response to the intermittent hypoxic stimulus. Objective Our objective was to systematically review the current state of the literature on the effects of chronic intermittent hypoxia–hyperoxia (IHH) on performance- and health-related outcomes in humans. Methods PubMed, Web of Science™, Scopus, and Cochrane Library databases were searched in accordance with PRISMA guidelines (January 2000 to September 2021) using the following inclusion criteria: (1) original research articles involving humans, (2) investigation of the chronic effect of IHH, (3) inclusion of a control group being not exposed to IHH, and (4) articles published in peer-reviewed journals written in English. Results Of 1085 articles initially found, eight studies were included. IHH was solely performed at rest in different populations including geriatric patients (n = 1), older patients with cardiovascular (n = 3) and metabolic disease (n = 2) or cognitive impairment (n = 1), and young athletes with overtraining syndrome (n = 1). The included studies confirmed the beneficial effects of chronic exposure to IHH, showing improvements in exercise tolerance, peak oxygen uptake, and global cognitive functions, as well as lowered blood glucose levels. A trend was discernible that chronic exposure to IHH can trigger a reduction in systolic and diastolic blood pressure. The evidence of whether IHH exerts beneficial effects on blood lipid levels and haematological parameters is currently inconclusive. A meta-analysis was not possible because the reviewed studies had a considerable heterogeneity concerning the investigated populations and outcome parameters. Conclusion Based on the published literature, it can be suggested that chronic exposure to IHH might be a promising non-pharmacological intervention strategy for improving peak oxygen consumption, exercise tolerance, and cognitive performance as well as reducing blood glucose levels, and systolic and diastolic blood pressure in older patients with cardiovascular and metabolic diseases or cognitive impairment. However, further randomized controlled trials with adequate sample sizes are needed to confirm and extend the evidence. This systematic review was registered on the international prospective register of systematic reviews (PROSPERO-ID: CRD42021281248) (https://www.crd.york.ac.uk/prospero/).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Intermittent Hypoxia–Hyperoxia on Performance- and Health-Related Outcomes in Humans: A Systematic Review

et al. 2022

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Effects of Intermittent Hypoxia-Hyperoxia Exposure Prior to Aerobic Cycling Exercise on Physical and Cognitive Performance in Geriatric Patients—A Randomized Controlled Trial

et al. 2022

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Background: It was recently shown that intermittent hypoxic-hyperoxic exposure (IHHE) applied prior to a multimodal training program promoted additional improvements in cognitive and physical performance in geriatric patients compared to physical training only. However, there is a gap in the literature to which extent the addition of IHHE can enhance the effects of an aerobic training. Therefore, the aim of this study was to investigate the efficacy of IHHE applied prior to aerobic cycling exercise on cognitive and physical performance in geriatric patients.Methods: In a randomized, two-armed, controlled, and single-blinded trial, 25 geriatric patients (77–94 years) were assigned to two groups: intervention group (IG) and sham control group (CG). Both groups completed 6 weeks of aerobic training using a motorized cycle ergometer, three times a week for 20 min per day. The IG was additionally exposed to intermittent hypoxic and hyperoxic periods for 30 min prior to exercise. The CG followed the similar procedure breathing sham hypoxia and hyperoxia (i.e., normoxia). Within 1 week before and after the interventions, cognitive performance was assessed with the Dementia-Detection Test (DemTect) and the Clock Drawing Test (CDT), while physical performance was measured using the Timed “Up and Go” Test (TUG) and the Short-Physical-Performance-Battery (SPPB).Results: No interaction effect was found with respect to the DemTect (ηp2 = 0.02). An interaction effect with medium effect size (ηp2 = 0.08) was found for CDT performance with a higher change over time for IG (d = 0.57) compared to CG (d = 0.05). The ANCOVA with baseline-adjustment indicated between-group differences with a large and medium effect size at post-test for the TUG (ηp2 = 0.29) and SPPB (ηp2 = 0.06) performance, respectively, in favour of the IG. Within-group post-hoc analysis showed that the TUG performance was worsened in the CG (d = 0.65) and remained unchanged in the IG (d = 0.19). Furthermore, SPPB performance was increased (d = 0.58) in IG, but no relevant change over time was found for CG (d = 0.00).Conclusion: The current study suggests that an additional IHHE prior to aerobic cycling exercise seems to be more effective to increase global cognitive functions as well as physical performance and to preserve functional mobility in geriatric patients in comparison to aerobic exercise alone after a 6-week intervention period.

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Relationship between Hypoxia and Hypercapnia Tolerance and Life Expectancy

Tregub,

Komleva,

Kulikov

et al. 2024

IJMS

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The review discusses the potential relationship between hypoxia resistance and longevity, the influence of carbon dioxide on the mechanisms of aging of the mammalian organism, and intermittent hypercapnic–hypoxic effects on the signaling pathways of aging mechanisms. In the article, we focused on the potential mechanisms of the gero-protective efficacy of carbon dioxide when combined with hypoxia. The review summarizes the possible influence of intermittent hypoxia and hypercapnia on aging processes in the nervous system. We considered the perspective variants of the application of hypercapnic–hypoxic influences for achieving active longevity and the prospects for the possibilities of developing hypercapnic–hypoxic training methods.

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Adaptation to Dosed Hypoxia-Hyperoxia as a Factor in the Improvement of Quality of Life for Elderly Patients with Cardiac Pathology

Cited by 3 publications

References 10 publications

Effects of Intermittent Hypoxia–Hyperoxia on Performance- and Health-Related Outcomes in Humans: A Systematic Review

Effects of Intermittent Hypoxia–Hyperoxia on Performance- and Health-Related Outcomes in Humans: A Systematic Review

Effects of Intermittent Hypoxia-Hyperoxia Exposure Prior to Aerobic Cycling Exercise on Physical and Cognitive Performance in Geriatric Patients—A Randomized Controlled Trial

Relationship between Hypoxia and Hypercapnia Tolerance and Life Expectancy

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