2011
DOI: 10.1007/s00421-011-1968-2
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Adaptation of the respiratory controller contributes to the attenuation of exercise hyperpnea in endurance-trained athletes

Abstract: We have reported that minute ventilation [[Formula: see text]] and end-tidal CO(2) tension [[Formula: see text]] are determined by the interaction between central controller and peripheral plant properties. During exercise, the controller curve shifts upward with unchanged central chemoreflex threshold to compensate for the plant curve shift accompanying increased metabolism. This effectively stabilizes [Formula: see text] within the normal range at the expense of exercise hyperpnea. In the present study, we i… Show more

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Cited by 15 publications
(23 citation statements)
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“…47 Rather, reduced CO 2 sensitivity has been reported only in endurancetrained athletes. 46,48 In addition, even if the subjects in this study had low CO 2 sensitivity to begin with, inactivity eliminates the depressed CO 2 sensitivity acquired during active training 27,47,49 and our subjects with PCS were inactive for an average of 9 weeks prior to exercise intervention. Therefore, even if they had experienced some level of a training effect to lower CO 2 sensitivity, it would likely have been lost during their prolonged period of inactivity.…”
Section: Discussionmentioning
confidence: 96%
“…47 Rather, reduced CO 2 sensitivity has been reported only in endurancetrained athletes. 46,48 In addition, even if the subjects in this study had low CO 2 sensitivity to begin with, inactivity eliminates the depressed CO 2 sensitivity acquired during active training 27,47,49 and our subjects with PCS were inactive for an average of 9 weeks prior to exercise intervention. Therefore, even if they had experienced some level of a training effect to lower CO 2 sensitivity, it would likely have been lost during their prolonged period of inactivity.…”
Section: Discussionmentioning
confidence: 96%
“…1B), quantitative analysis of both subsystems can determine how changes in both the controller and plant elements affect V E or Pa CO 2 (5,6,17,18,41,45,46,48); however, to what extent changes in central blood volume (CBV) influence these variables and thus, by consequence, the operating point (V E or Pa CO 2 response) of the respiratory control system remain unclear.…”
mentioning
confidence: 99%
“…It can be divided into two subsystems (Fig. 1A): a controller (controlling element) and a plant (controlled element) (5,17,18,21,35,41,45,46).Recently, we have characterized these subsystem elements in an open-loop condition and constructed a respiratory equilibrium diagram to illustrate the mechanisms of respiratory control at rest and during exercise in endurance-trained and untrained subjects (46,48,52). Briefly, the controller element approximates a straight line where minute ventilation (V E) increases as a function of Pa CO 2 .…”
mentioning
confidence: 99%
“…[18]) whole respiratory control system will greatly advance the elucidation of pathological conditions manifesting breathing disorders and respiratory regulation during exercise. In the future, studies that combine analytical techniques for dynamic control functions of the respiratory control system are anticipated to provide an approach from a hitherto unexplored perspective for basic and applied research in exercise physiology.…”
Section: Resultsmentioning
confidence: 99%