Adaptation of the cortical somatosensory evoked potential following pulsed pneumatic stimulation of the lower face in adults

Custead, Rebecca; Oh, Hyuntaek; Rosner, Austin Oder

doi:10.1016/j.brainres.2015.06.025

Cited by 13 publications

(10 citation statements)

References 64 publications

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“…The PC laptop computer, Galileo SomatosensoryTM pneumatic controller, and integrated dual-cylinder pump motor are all located outside the shielded MRI scanner suite room. As shown in Fig 1 , the TAC-Cell is essentially a small capsule with a sealing flange (6 mm ID, 15 mm OD), which can be adhered rapidly to virtually any skin surface, including the glabrous hand and face [ 6 , 43 , 44 ].…”

Section: Methodsmentioning

confidence: 99%

“…Among the many functions of the somatosensory system, processing information about the location, velocity and traverse length of tactile stimuli on the body surface is presumed essential for the development and maintenance of fine motor control of the hand [ 3 – 5 ]. Improving our knowledge of velocity and directional encoding in this sensory domain will help formulate innovative neurotherapeutic strategies for the rehabilitation of brain-damaged patients to regain motor skills in the limb (hand, foot) and orofacial (speech, gesture, swallowing) systems [ 6 ]. Limited data exist on the cortical representation of moving touch stimulation on the glabrous skin of the digits in humans [ 7 , 8 ], and many studies involving sensorimotor tasks have been limited to neurotypical adults using electrical and/or transcranial magnetic stimulation (TMS) [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Neural encoding of saltatory pneumotactile velocity in human glabrous hand

Custead

Wang

2017

PLoS ONE

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Neurons in the somatosensory cortex are exquisitely sensitive to mechanical stimulation of the skin surface. The location, velocity, direction, and adaptation of tactile stimuli on the skin’s surface are discriminable features of somatosensory processing, however the representation and processing of dynamic tactile arrays in the human somatosensory cortex are poorly understood. The principal aim of this study was to map the relation between dynamic saltatory pneumatic stimuli at discrete traverse velocities on the glabrous hand and the resultant pattern of evoked BOLD response in the human brain. Moreover, we hypothesized that the hand representation in contralateral Brodmann Area (BA) 3b would show a significant dependence on stimulus velocity. Saltatory pneumatic pulses (60 ms duration, 9.5 ms rise/fall) were repetitively sequenced through a 7-channel TAC-Cell array at traverse velocities of 5, 25, and 65 cm/s on the glabrous hand initiated at the tips of D2 (index finger) and D3 (middle finger) and sequenced towards the D1 (thumb). The resulting hemodynamic response was sampled during 3 functional MRI scans (BOLD) in 20 neurotypical right-handed adults at 3T. Results from each subject were inserted to the one-way ANOVA within-subjects and one sample t-test to evaluate the group main effect of all three velocities stimuli and each of three different velocities, respectively. The stimulus evoked BOLD response revealed a dynamic representation of saltatory pneumotactile stimulus velocity in a network consisting of the contralateral primary hand somatosensory cortex (BA3b), associated primary motor cortex (BA4), posterior insula, and ipsilateral deep cerebellum. The spatial extent of this network was greatest at the 5 and 25 cm/s pneumotactile stimulus velocities.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neural encoding of saltatory pneumotactile velocity in human glabrous hand

Custead

Wang

2017

PLoS ONE

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“…Furthermore, neuroimaging studies also indicated that there are different cortical representations for different tactile stimuli in humans (e.g., location, type of motion, direction, velocity, etc.) (Reed et al, 2004;Miyamoto et al, 2006;Backlund Wasling et al, 2008;Eickhoff et al, 2008;Bjornsdotter et al, 2009;Moulton et al, 2009;Avivi-Arber et al, 2011;Grabski et al, 2012;Huang et al, 2012;Khoshnejad et al, 2014;Yang et al, 2014;Custead et al, 2015Custead et al, , 2017Hwang et al, 2017;Oh et al, 2017;Yeon et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Functional Connectivity Evoked by Orofacial Tactile Perception of Velocity

et al. 2020

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The cortical representations of orofacial pneumotactile stimulation involve complex neuronal networks, which are still unknown. This study aims to identify the characteristics of functional connectivity (FC) evoked by three different saltatory velocities over the perioral and buccal surface of the lower face using functional magnetic resonance imaging in twenty neurotypical adults. Our results showed a velocity of 25 cm/s evoked stronger connection strength between the right dorsolateral prefrontal cortex and the right thalamus than a velocity of 5 cm/s. The decreased FC between the right secondary somatosensory cortex and right posterior parietal cortex for 5-cm/s velocity versus all three velocities delivered simultaneously ("All ON") and the increased FC between the right thalamus and bilateral secondary somatosensory cortex for 65 cm/s vs "All ON" indicated that the right secondary somatosensory cortex might play a role in the orofacial tactile perception of velocity. Our results have also shown different patterns of FC for each seed (bilateral primary and secondary somatosensory cortex) at various velocity contrasts (5 vs 25 cm/s, 5 vs 65 cm/s, and 25 vs 65 cm/s). The similarities and differences of FC among three velocities shed light on the neuronal networks encoding the orofacial tactile perception of velocity.

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“…The pneumotactile stimulator in the present study (GALILEO Somatosensory TM ) uses a chambered tactile cell (TAC-Cell) which can be applied quickly to the skin of any population using double adhesive tape collars, with scalable and programmable control to create saltatory tactile arrays unique to study designs. Recent studies utilizing pulse trains of pneumotactile stimulation at different stimulus rates (2-6 Hz) with just a single TAC-Cell placed on either the glabrous hand or lower face have shown significant and unique short-and long-term adaptation patterns in S1, S2, and posterior parietal cortex (PPC) using magnetoencephalography source localization methods (Popescu et al, , 2013Venkatesan et al, 2010Venkatesan et al, , 2014, and electroencephalography (Custead et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Brain encoding of saltatory velocity through a pulsed pneumotactile array in the lower face

Custead

Wang

2017

Brain Research

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Processing dynamic tactile inputs is a primary function of the somatosensory system. Spatial velocity encoding mechanisms by the nervous system are important for skilled movement production and may play a role in recovery of sensorimotor function following neurological insult. Little is known about tactile velocity encoding in mechanosensory trigeminal networks required for speech, suck, mastication, and facial gesture. High resolution functional magnetic resonance imaging (fMRI) was used to investigate the neural substrates of velocity encoding in the human orofacial somatosensory system during unilateral saltatory pneumotactile stimulation of perioral and buccal hairy skin in 20 neurotypical adults. A custom multichannel, scalable pneumotactile array consisting of 7 TAC-Cells was used to present 5 stimulus conditions: 5cm/s, 25cm/s, 65cm/s, ALL-ON synchronous activation, and ALL-OFF. The spatiotemporal organization of whole-brain blood oxygen level-dependent (BOLD) response was analyzed with general linear modeling (GLM) and fitted response estimates of percent signal change to compare activations associated with each velocity, and the main effect of velocity alone. Sequential saltatory inputs to the right lower face produced localized BOLD responses in 6 key regions of interest (ROI) including; contralateral precentral and postcentral gyri, and ipsilateral precentral, superior temporal (STG), supramarginal gyri (SMG), and cerebellum. The spatiotemporal organization of the evoked BOLD response was highly dependent on velocity, with the greatest amplitude of BOLD signal change recorded during the 5cm/s presentation in the contralateral hemisphere. Temporal analysis of BOLD response by velocity indicated rapid adaptation via a scalability of networks processing changing pneumotactile velocity cues.

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Adaptation of the cortical somatosensory evoked potential following pulsed pneumatic stimulation of the lower face in adults

Cited by 13 publications

References 64 publications

Neural encoding of saltatory pneumotactile velocity in human glabrous hand

Neural encoding of saltatory pneumotactile velocity in human glabrous hand

Functional Connectivity Evoked by Orofacial Tactile Perception of Velocity

Brain encoding of saltatory velocity through a pulsed pneumotactile array in the lower face

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