Adaptation of rat gastric tissue against indomethacin toxicity

Polat, Beyzagül; Süleyman, Halis; Hakan, Hamit

doi:10.1016/j.cbi.2010.03.041

Cited by 47 publications

(35 citation statements)

References 52 publications

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“…In the experimental induction of gastric ulcers by a NSAID, the AHQ (200 mg/kg) presented gastroprotection. Given that the ulcerogenic properties of NSAIDs are due to the fact that they diminish the protective factors of the mucosa such as prostaglandins and mucus (Konturek et al, 2005;Polat et al, 2010), it can be affirmed that the antiulcerogenic activity of AHQ observed in this model must augment these mucosal protective factors. In this sense, aiming this hypothesis, we evaluated the AHQ action on mucus secretion in the gastric mucosa.…”

Section: Discusssionmentioning

confidence: 83%

Antiulcerogenic activity of the aqueous fraction of Anacardium humile St. Hil (Anacardiaceae)

Luiz-Ferreira¹,

Cola²,

Barbastefano³

et al. 2012

J. Med. Plants Res.

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Anacardium humile St. Hil. is being used in traditional medicine to treat ulcer. The present work evaluated the mechanisms of action involved in the anti-ulcer properties of the aqueous fraction from leaves of A. humile (AHQ). Gastroprotection of A. humile was evaluated in ethanol and piroxicam models. Mechanisms of action such as mucus production, nitric oxide (NO), sulfhydryl compounds (SH) and the anti-secretory action were evaluated. The acetic acid-induced gastric ulcer model was used to evaluate the A. humile healing properties. Results obtained in the ethanol model showed that AHQ provided significant gastroprotection at all the tested doses (50, 100, and 200 mg/kg). Thereby, the following protocols were performed using the dose capable of producing the most effective gastroprotection, which was the AHQ 200 mg/kg (P < 0.001). Moreover, AHQ (200 mg/kg) protected the mucosa from piroxicam-induced damage. Mucus, NO, and SH did not participate on this gastroprotection. AHQ interfere in H + secretion in gastric mucosa, thus exerting an anti-secretory activity. Our results suggest that the gastroprotection and cicatrisation process executed by AHQ occurred due to its anti-secretory activity. This study reinforces its traditional medicinal use. Considering that the current therapies are based on the use of anti-secretory agents, the A. humile arises as a promising alternative antiulcer therapy.

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Section: Discusssionmentioning

confidence: 83%

Antiulcerogenic activity of the aqueous fraction of Anacardium humile St. Hil (Anacardiaceae)

Luiz-Ferreira¹,

Cola²,

Barbastefano³

et al. 2012

J. Med. Plants Res.

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“…One of the limitations of this study was that we were not able to give high dose of INDO to the rats due to gastrointestinal bleeding (Polat et al 2010). To make a better comparison in this experimental setup, we could not show another NSAID, INDOs' possible harmful effect on vascular relaxation.…”

Section: Discussionmentioning

confidence: 94%

Antioxidative effect of aspirin on vascular function of aged ovariectomized rats

Demirci

Demir

Dost

et al. 2013

AGE

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This study investigated the vascular effects of nonsteroidal anti-inflammatory drugs (NSAIDs) in the very late stage of postmenopausal vascular aging and looked for a better choice of anti-inflammatory drug for women in reducing the cardiovascular risk by decreasing the oxidant status in this term. The rat aorta isolated from young and old rats that were treated with either aspirin (10 mg/kg/day) or indomethacin (INDO, 1 mg/kg/day) within last 10 weeks after 16-month overiectomy (OVX) follow-up. Endothelium-dependant acetylcholine (Ach, 0.001-30 μM) and independent sodium nitroprusside (SNP, 0.0001-3 μM) relaxant; α-receptor phenylephrine (PE, 0.001-30 μM) and voltage-dependant high potassium (KCl; 40 mM) contractile responses were assessed. Total oxidant and antioxidant status were measured from the serum samples. Aged OVX rat's both aortic endothelium and smooth muscle relaxation were significantly less than of younger ones, whereas their contractile functions tended to decrease. INDO did not treat the Ach, SNP responses, whereas it increased the PE and KCl contractility. Aspirin improved the relaxation function and antioxidant capacity and decreased the oxidant status. These data demonstrate that even if they are in the very late stage of life and menopause, the analgesic choices could restore the well established endothelial dysfunction, vascular stiffness, and oxidant status.

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“…It was stated that the amount of 8-OHGua in I/R and other tissue damage models rose in parallel to the increase of the oxidant parameters. 30,31 In the renal tissue of the RIR group, in which the MDA, MPO, and 8-OHGua levels proved to be high, a decrease in the COX-1 activity and a rise in the COX-2 activity were recorded. COX-1 is responsible for the synthesis of cytoprotective prostaglandins.…”

Section: Discussionmentioning

confidence: 95%

The effect of nimesulide on oxidative damage inflicted by ischemia–reperfusion on the rat renal tissue

et al. 2014

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The objective of our study is to research biochemically and histopathologically the effect of nimesulide on oxidative damage inflicted by ischemia-reperfusion (I/R) on the rat renal tissue. Twenty-four albino Wistar type of male rats were used for the experiment. The animals were divided into groups as: renal ischemia-reperfusion control (RIR), nimesulide + renal ischemiareperfusion of 50 mg/kg (NRIR-50), nimesulide + renal ischemia-reperfusion of 100 mg/kg (NRIR-100), and sham groups (SG). In NRIR-50 and NRIR-100 groups were given nimesulide, and RIR and SG groups were given distilled water, an hour after anesthesia. Groups, except for the SG group, 1-h-ischemia and then 6-h-reperfusion were performed. In the renal tissue of the RIR group in which the malondialdehyde (MDA), myeloperoxidase (MPO), and 8-hydroxyguanine (8-OHGua) levels were measured, the COX-1 and COX-2 activities were recorded. Nimesulide at 100 mg/kg doses reduced the oxidant parameters more significantly than 50 mg/kg doses; on the other hand, it raised the antioxidant parameters. It has been shown that 100 mg/kg doses of nimesulide prevented the renal I/R damage more significantly than a dose of 50 mg/kg, which shows that nimesulide, in clinics, could be used in the prevention of I/R damage.

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Adaptation of rat gastric tissue against indomethacin toxicity

Cited by 47 publications

References 52 publications

Antiulcerogenic activity of the aqueous fraction of Anacardium humile St. Hil (Anacardiaceae)

Antiulcerogenic activity of the aqueous fraction of Anacardium humile St. Hil (Anacardiaceae)

Antioxidative effect of aspirin on vascular function of aged ovariectomized rats

The effect of nimesulide on oxidative damage inflicted by ischemia–reperfusion on the rat renal tissue

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