Adaptation of enteroendocrine cells in response to jejunal-lleal transposition in the rat

The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat

“…The findings were coupled with changes in hormonal gene expression patterns as well as hormonal plasma levels in rodents [1,21,[42][43][44][45][46][47][48][49][50]. Collectively, these data confirmed that IT surgery leads to considerable changes in the gut.…”

Nutritional effects of the serial transverse enteroplasty procedure in experimental short bowel syndrome

“…Increased meal stimulated GLP-2 production after resection has been shown to be a fundamental regulator of intestinal adaptation, likely because of increased direct stimulation of the L-cell by partially absorbed nutrients [15,31,32]. The number of L-cells remains remarkably constant after resection, and the present study documents well that there is no alteration in nutrient transit rates [33]; thus, it is seems most likely that the STEP procedure is altering the enteroendocrine response by affecting enteric neuronal signaling to the L-cell, most likely in the colon [29,30]. It has been shown that the vagus and descending enteric neuronal input play a large role in the normal, physiologic postprandial release of GLP-2 [29,30].…”

Comparison of Ileal and Jejunal Transplantation after 50% Proximal Intestinal Resection

“…These parameters were greater in the proximal transplanted segment of both groups compared with the proximal jejunum of transection controls. Similarly, in transposition models, the ileum achieves a villus height similar to that of jejunum when interposed proximally, whereas the jejunum loses villus height when moved distally in the gastrointestinal tract [3][4][5][6]. Unlike previous transposition studies, however, the transplanted ileum in the present study was in continuity with an intact ileal remnant.…”

“…Certain regional properties do not appear to be influenced by transposition of intestinal segments. Aiken et al [4] found no change in the region-specific expression of enteroendocrine cell populations or their products.…”

“…Transposition studies suggest that this is, in part, related to an increased exposure of the ileum to nutrients and pancreaticobiliary secretions after proximal resection [3][4][5][6]. However, there may be certain features intrinsic to the ileum, e.g., hormonal content of enterocytes, that contribute to this response as well [4].…”