Adaptation in the compound action potential response of the guinea pig VIIIth nerve to electric stimulation

Killian, Matthijs; Klis, Sjaak F.L.; Smoorenburg, Guido F.

doi:10.1016/0378-5955(94)90154-6

Cited by 35 publications

(34 citation statements)

References 71 publications

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“…They also reported occasional non-monotonic recovery functions that had a comparable time course to those presented in this manuscript. The recovery characteristics of the ECAP reported by Killian (1994) were very similar in cochleae with and without functional hair cells (cf. Fig.…”

Section: Comparison With Other Relevant Ecap and Single-fiber Studiesmentioning

confidence: 55%

“…The data of Abbas et al (2001) suggest that greater noise durations might cause a slower recovery of the ECAP. Killian (1994) and Killian et al (1994) addressed forward masking of the ECAP in guinea pigs using 100-300 ms sinusoidal electric maskers. Using 5 ms 15 kHz electric sinusoids and 20 μs/phase biphasic electric pulses, they reported trends similar to the findings of our study.…”

Section: Comparison With Other Relevant Ecap and Single-fiber Studiesmentioning

confidence: 99%

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Acoustic–electric interactions in the guinea pig auditory nerve: Simultaneous and forward masking of the electrically evoked compound action potential

et al. 2007

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The study investigated the time course of the effects of acoustic and electric stimulation on the electrically evoked compound action potential (ECAP). Adult guinea pigs were used in acute experimental sessions. Bursts of acoustic noise and high-rate (5000 pulses/s) electric pulse trains were used as maskers. Biphasic electric pulses were used as probes. ECAPs were recorded from the auditory nerve trunk.Simultaneous masking of the ECAP with acoustic noise featured an onset effect and a decrease in the amount of masking to a steady state. It was characterized by a two-component exponential function. The amount of masking increased with masker level and decreased with probe level. Poststimulatory ECAP recovery often featured a non-monotonic time course, described by a threecomponent exponent. Electric maskers produced similar post-stimulatory effects in hearing and acutely deafened subjects.Acoustic stimulation affects the ECAP in a level-and time-dependent manner. Simultaneous masking follows a time course comparable to that of adaptation to an acoustic stimulus. Refractoriness, spontaneous activity, and adaptation are suggested to play a role in ECAP recovery. Post-stimulatory changes in synchrony, possibly due to recovery of spontaneous activity and an additional hair-cell independent mechanism, are hypothesized to contribute to the observed non-monotonicity of recovery.

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Section: Comparison With Other Relevant Ecap and Single-fiber Studiesmentioning

confidence: 55%

Section: Comparison With Other Relevant Ecap and Single-fiber Studiesmentioning

confidence: 99%

Acoustic–electric interactions in the guinea pig auditory nerve: Simultaneous and forward masking of the electrically evoked compound action potential

et al. 2007

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“…In acoustic hearing, the origin of forward masking at the long probe delays was thought to be due to depletion of neurotransmitters in the hair-cell auditory-neuron synapse (Smith and Brachman, 1982;Westerman and Smith, 1984). However, electrically evoked compound action potentials (ECAPs) measured in animals with deafened cochleae without hair cells indicated that the origin of adaptation could well be at the level of the eighth nerve (Killian et al, 1994). There is also evidence to indicate that the origin of adaptation could be central to the auditory nerve.…”

Section: Discussionmentioning

confidence: 99%

Evaluating multipulse integration as a neural-health correlate in human cochlear-implant users: Relationship to forward-masking recovery

Zhou¹,

Pfingst²

2016

The Journal of the Acoustical Society of America

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The present study evaluated the slopes of threshold-versus-pulse-rate functions (multipulse integration, MPI) in humans with cochlear implants in relation to recovery from 300-ms forward maskers. MPI has been correlated with spiral ganglion cell density in animals. The present study showed that steeper MPI functions were correlated with faster recovery from forward masking. The findings suggested that the variations in the MPI slopes are explained not only by the quantity of neurons contributing to the integration process but also by the neurons' temporal response characteristics and possibly central inhibition.

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“…The electrically evoked compound action potential (ECAP) from the auditory nerve is characterised by a large negative peak (N1) with a very short latency (within a fraction of a millisecond), followed by a positive peak (P1) 1 as described by Killian et al [1994] and illustrated in figure 1. Neural response telemetry [NRT™, 1999] is a feature of the Nucleus ® 24 cochlear implant system combined with the Windows ® -based NRT software developed by Dillier and Lai. It enables measurements of the ECAP 1 As NRT is a near-field measurement, there is no positive peak prior to N1; thus, we have adopted the nomenclature of Killian et al in 1994, since this more accurately describes the ECAP as measured with NRT. via bidirectional telemetry using the electrodes of the implant without the need of external electrodes.…”

Section: Introductionmentioning

confidence: 99%

“…Neural response telemetry [NRT™, 1999] is a feature of the Nucleus ® 24 cochlear implant system combined with the Windows ® -based NRT software developed by Dillier and Lai. It enables measurements of the ECAP 1 As NRT is a near-field measurement, there is no positive peak prior to N1; thus, we have adopted the nomenclature of Killian et al in 1994, since this more accurately describes the ECAP as measured with NRT. via bidirectional telemetry using the electrodes of the implant without the need of external electrodes. Abbas et al [1999] and Dillier et al [2002] validated a simplified and reliable clinical procedure for ECAP measurements in adults.…”

Section: Introductionmentioning

confidence: 99%

Normative Findings of Electrically Evoked Compound Action Potential Measurements Using the Neural Response Telemetry of the Nucleus CI24M Cochlear Implant System

et al. 2005

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One hundred and forty-seven adult recipients of the Nucleus 24 cochlear implant system, from 13 different European countries, were tested using neural response telemetry to measure the electrically evoked compound action potential (ECAP), according to a standardised postoperative measurement procedure. Recordings were obtained in 96% of these subjects with this standardised procedure. The group results are presented in terms of peak amplitude and latency, slope of the amplitude growth function and ECAP threshold. The effects of aetiological factors and the duration of deafness on the ECAP were also studied. While large intersubject variability and intrasubject variability (across electrodes) were found, results fell within a consistent pattern and a normative range of peak amplitudes and latencies was established. The aetiological factors had little effect on the ECAP characteristics. However, age affected ECAP amplitude and slope of the amplitude growth function significantly; i.e., the amplitude is higher in the lowest age category (15-30 years). Principal component analysis of the ECAP thresholds shows that the thresholds across 5 electrodes can be described by two factors accounting for 92% of the total variance. The two factors represent the overall level of the threshold profiles ('shift') and their slopes across the electrode array ('tilt'). Correlation between these two factors and the same factors describing the T-and C-levels appeared to be moderate, in the range of 0.5-0.6. AbstractOne hundred and forty-seven adult recipients of the Nucleus ® 24 cochlear implant system, from 13 different European countries, were tested using neural response telemetry to measure the electrically evoked compound action potential (ECAP), according to a standardised postoperative measurement procedure. Recordings were obtained in 96% of these subjects with this standardised procedure. The group results are presented in terms of peak amplitude and latency, slope of the amplitude growth function and ECAP threshold. The effects of aetiological factors and the duration of deafness on the ECAP were also studied. While large intersubject variability and intrasubject variability (across electrodes) were found, results fell within a consistent pattern and a normative range of peak amplitudes and latencies was established. The aetiological factors had little effect on the ECAP characteristics. However, age affected ECAP amplitude and slope of the amplitude growth function significantly; i.e., the amplitude is higher in the lowest age category (15-30 years). Principal component analysis of the ECAP thresholds shows that the thresholds across 5 electrodes can be described by two factors accounting for 92% of the total variance. The two factors represent the overall level of the threshold profiles ('shift') and their slopes across the electrode array ('tilt'). Correlation between these two factors and the same factors describing the T-and C-levels appeared to be moderate, in the range of 0.5-0.6.

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Adaptation in the compound action potential response of the guinea pig VIIIth nerve to electric stimulation

Cited by 35 publications

References 71 publications

Acoustic–electric interactions in the guinea pig auditory nerve: Simultaneous and forward masking of the electrically evoked compound action potential

Acoustic–electric interactions in the guinea pig auditory nerve: Simultaneous and forward masking of the electrically evoked compound action potential

Evaluating multipulse integration as a neural-health correlate in human cochlear-implant users: Relationship to forward-masking recovery

Normative Findings of Electrically Evoked Compound Action Potential Measurements Using the Neural Response Telemetry of the Nucleus CI24M Cochlear Implant System

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