Adaptable DNA interactions regulate surface triggered self assembly

Lanfranco, Roberta; Jana, Pritam Kumar; Bruylants, Gilles; Cicuta, Pietro; Mognetti, Bortolo Matteo; Michele, Lorenzo Di

doi:10.1039/d0nr04461j

Cited by 9 publications

(15 citation statements)

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“…Besides temporal control, multivalent DNA-mediated interactions can also be harnessed to program spatially heterogeneous self-assembly phenomena, as demonstrated by Lanfranco et. al 109 . Here, the authors exploited a toehold-mediated exchange interaction scheme similar to the one discussed above 81 , and combined it with rationally-designed bond-competition to demonstrate self-limiting colloidal self-assembly triggered by a functional interface.…”

Section: Chemcomm Accepted Manuscriptmentioning

confidence: 98%

“…streptavidin, antibodies) and metabolites. These membrane-bound DNA nanostructures display lateral diffusivity at rates similar to the surrounding lipids [107][108][109] , which thus enables their lateral re-distribution as driven by free-energy minimisation 88 . In what follows, we will refer to these DNA constructs either using the bio-inspired term "receptors", or simply as "linkers".…”

Section: Dna Receptors To Regulate Membrane Adhesion and Tissue Formationmentioning

confidence: 99%

“…Adapted with permission from ref. 109 Copyright 2020, The Royal Society of Chemistry. g. Histograms conveying the average number of particles per adhesion layer at increasing fractions of receptors f .…”

Section: Chemcomm Accepted Manuscriptmentioning

confidence: 99%

“…(Right) Bright-field micrograph of a representative substrate bead and surrounding particles featuring a fraction of receptors f = 0.2. Adapted with permission from ref 109. Copyright 2020, The Royal Society of Chemistry.…”

mentioning

confidence: 99%

“…g. Histograms conveying the average number of particles per adhesion layer at increasing fractions of receptors f . Adapted with permission from ref 109. Copyright 2020, The Royal Society of Chemistry.…”

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confidence: 99%

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Amphiphilic DNA nanostructures for bottom-up synthetic biology

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Section: Chemcomm Accepted Manuscriptmentioning

confidence: 98%

Section: Dna Receptors To Regulate Membrane Adhesion and Tissue Formationmentioning

confidence: 99%

Section: Chemcomm Accepted Manuscriptmentioning

confidence: 99%

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Amphiphilic DNA nanostructures for bottom-up synthetic biology

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Engineering DNA‐Grafted Quatsomes as Stable Nucleic Acid‐Responsive Fluorescent Nanovesicles

Rossetti

Stella

Morlà-Folch

et al. 2021

Adv Funct Materials

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The development of artificial vesicles into responsive architectures capable of sensing the biological environment and simultaneously signaling the presence of a specific target molecule is a key challenge in a range of biomedical applications from drug delivery to diagnostic tools. Herein, the rational design of biomimetic DNA-grafted quatsome (QS) nanovesicles capable of translating the binding of a target molecule to amphiphilic DNA probes into an optical output is presented. QSs are synthetic lipid-based nanovesicles able to confine multiple organic dyes at the nanoscale, resulting in ultra-bright soft materials with attractiveness for sensing applications. Dye-loaded QS nanovesicles of different composition and surface charge are grafted with fluorescent amphiphilic nucleic acid-based probes to produce programmable FRET-active nanovesicles that operate as highly sensitive signal transducers. The photophysical properties of the DNA-grafted nanovesicles are characterized and the highly selective, ratiometric detection of clinically relevant microRNAs with sensitivity in the low nanomolar range are demonstrated. The potential applications of responsive QS nanovesicles for biosensing applications but also as functional nanodevices for targeted biomedical applications is envisaged.

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Differential dynamic microscopy for the characterization of polymer systems

Cerbino

Giavazzi

Helgeson

2021

Journal of Polymer Science

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This review summarizes recent progress in investigating polymer systems by using Differential dynamic microscopy (DDM), a rapidly emerging approach that transforms a commercial microscope by combining real-space information with the powerful capabilities of conventional light scattering analysis. DDM analysis of a single microscope movie gives access to the sample dynamics in a wide range of scattering wave-vectors, enabling contemporary polymer science experiments that would be difficult or impossible with standard light scattering techniques. Examples of application include the characterization of polymer solutions and networks, of polymer based colloidal systems, of biopolymers, and of cellular motility in polymeric fluids. Further applications of DDM to a variety of polymer systems are suggested to be just behind the corner and it is thus likely that DDM will become a tool of choice of the modern experimental polymer scientists.

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Adaptable DNA interactions regulate surface triggered self assembly

Abstract: DNA-mediated multivalent interactions between colloidal particles have been extensively applied for their ability to program bulk phase behaviour and dynamic processes. Exploiting the competition between different types of DNA-DNA bonds,...

Cited by 9 publications

References 35 publications

Amphiphilic DNA nanostructures for bottom-up synthetic biology

Amphiphilic DNA nanostructures for bottom-up synthetic biology

Engineering DNA‐Grafted Quatsomes as Stable Nucleic Acid‐Responsive Fluorescent Nanovesicles

Differential dynamic microscopy for the characterization of polymer systems

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