Adapalene Gel, 0.1%, as Maintenance Therapy for Acne Vulgaris

Thiboutot, Diane; Shalita, Alan R.; Yamauchi, Paul S.; Dawson, Catherine; Kerrouche, Nabil; Arsonnaud, Stéphanie; Kang, Sewon

doi:10.1001/archderm.142.5.597

Cited by 79 publications

(20 citation statements)

References 15 publications

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“…Thiboutot et al [32] and Alirezai et al [33] assessed the maintenance effect of adapalene gel 0.1% relative to gel vehicle in patients previously treated in 12-week tetracycline-adapalene combination therapy studies. The main efficacy parameters included maintenance rate, which corresponds to the percentage of patients maintaining at least 50% improvement in lesion counts from previous induction therapy, and lesion counts.…”

Section: Discussionmentioning

confidence: 99%

Maintenance Therapy for Acne Vulgaris: Efficacy of a 12-Month Treatment with Adapalene-Benzoyl Peroxide after Oral Isotretinoin and a Review of the Literature

et al. 2013

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Background: The correct therapeutic management of acne should include a maintenance therapy with topical retinoids to prevent recurrences after discontinuing a successful treatment. Objective: To investigate the efficacy of a 12-month maintenance treatment with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% fixed combination gel to control acne relapse after treatment with oral isotretinoin (OI). Methods: The study consisted of 2 phases, namely an active treatment phase (AP) and a maintenance phase (MP). In the AP, 70 consecutive patients with moderate to severe acne were treated with OI until acne remission. Then, patients entered the MP and were treated with adapalene-BPO fixed combination once daily for 12 months. The primary efficacy parameter was the relapse rate during MP. Results: Sixty-eight patients completed the study. Relapse occurred in 2 patients (2.94%). Conclusions: Comparing our findings with published data, the association of a topical retinoid and BPO seems to provide favorable evidence for this combination as maintenance therapy.

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Section: Discussionmentioning

confidence: 99%

Maintenance Therapy for Acne Vulgaris: Efficacy of a 12-Month Treatment with Adapalene-Benzoyl Peroxide after Oral Isotretinoin and a Review of the Literature

et al. 2013

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“…In contrast to the lack of statistical significance with respect to the grading used in the studies by Thiboutout et al [8] and Alirezei et al [7], the pooled effect of adapalene versus vehicle on the ‘number of patients maintaining at least 50% improvement achieved in the initial study' was statistically significant based on inflammatory (IL) and non-inflammatory lesion (NIL) count [7,8] (fig. 3).…”

Section: Resultsmentioning

confidence: 97%

“…The skin type/ethnic background, if stated, was: 100% Mongoloid [6], 87.5% Caucasian and 8.8% black [7], 75% white and 15.5% black [8], 45% white and 36% black [9]. Each of the included maintenance RCTs was a follow-up of an initial RCT on induction therapy.…”

Section: Resultsmentioning

confidence: 99%

“…Three placebo-controlled RCTs [6,7,8] evaluated adapalene 0.1% gel applied once daily (table 2). The RCTs included responders who had achieved ‘at least moderate improvement' during the induction therapy phase (assessed using different scales in each study, see below).…”

Section: Resultsmentioning

confidence: 99%

“…In 2006, Thiboutot et al [8] had conducted a 12-week induction RCT comparing adapalene 0.1% gel plus doxycycline 100 mg compared to doxycycline 100 mg alone. Responders, those who achieved at least moderate improvement, were then re-randomized to receive adapalene gel 0.1% q.d.…”

Section: Resultsmentioning

confidence: 99%

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How Much Do We Know about Maintaining Treatment Response after Successful Acne Therapy? Systematic Review on the Efficacy and Safety of Acne Maintenance Therapy

Dressler

Rosumeck²,

Nast

2016

Dermatology

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After cessation of successful initial acne therapy, patients often experience flares. Consecutive maintenance treatment after successful induction therapy is promoted by guidelines; however, little is known about the efficacy/safety of different maintenance regimens. A systematic review on acne maintenance treatments was conducted. We identified 5 randomized controlled trials [RCTs; adapalene vs. vehicle or vs. no treatment (3 RCTs), adapalene/benzoyl peroxide (BPO) vs. vehicle, combination/monotherapy of minocycline (systemic)/tazarotene/placebo] and 3 non-RCTs on systemic isotretinoin, adapalene/BPO and azelaic acid. The results of adapalene versus vehicle/no treatment varied depending on the reported outcome. The ‘number of patients maintaining at least 50% improvement' counting inflammatory lesions/non-inflammatory lesions with adapalene was superior to vehicle (risk ratio, RR 1.24, 95% confidence interval, CI 1.08-1.43/RR 1.34, 95% CI 1.18-1.59). However, no significant differences were found in 2 of 3 RCTs for maintaining ‘clear/almost clear' or ‘mild acne' or on the global grading score. For the combination regimens of minocycline/tazarotene/placebo, no significant differences were found. Adapalene/BPO was superior to vehicle counting inflammatory lesions/non-inflammatory lesions (RR 1.61, 95% CI 1.31-1.99; RR 1.80, 95% CI 1.44-2.26). Due to the scarcity of studies, few conclusions can be drawn. More homogeneous outcome measures and specific maintenance study designs may lead to more robust findings.

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Acne Maintenance Therapy

Zane¹

2006

Arch Dermatol

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Adapalene Gel, 0.1%, as Maintenance Therapy for Acne Vulgaris

Abstract: Objective: To assess the maintenance effect of adapalene gel, 0.1%, relative to gel vehicle in subjects successfully treated in a previous 12-week study of adapalenedoxycycline, 100 mg, combination therapy.

Cited by 79 publications

References 15 publications

Maintenance Therapy for Acne Vulgaris: Efficacy of a 12-Month Treatment with Adapalene-Benzoyl Peroxide after Oral Isotretinoin and a Review of the Literature

Maintenance Therapy for Acne Vulgaris: Efficacy of a 12-Month Treatment with Adapalene-Benzoyl Peroxide after Oral Isotretinoin and a Review of the Literature

How Much Do We Know about Maintaining Treatment Response after Successful Acne Therapy? Systematic Review on the Efficacy and Safety of Acne Maintenance Therapy

Acne Maintenance Therapy

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