2006
DOI: 10.1001/archderm.142.5.597
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Abstract: Objective: To assess the maintenance effect of adapalene gel, 0.1%, relative to gel vehicle in subjects successfully treated in a previous 12-week study of adapalenedoxycycline, 100 mg, combination therapy.

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Cited by 76 publications
(14 citation statements)
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“…Thiboutot et al [32] and Alirezai et al [33] assessed the maintenance effect of adapalene gel 0.1% relative to gel vehicle in patients previously treated in 12-week tetracycline-adapalene combination therapy studies. The main efficacy parameters included maintenance rate, which corresponds to the percentage of patients maintaining at least 50% improvement in lesion counts from previous induction therapy, and lesion counts.…”
Section: Discussionmentioning
confidence: 99%
“…Thiboutot et al [32] and Alirezai et al [33] assessed the maintenance effect of adapalene gel 0.1% relative to gel vehicle in patients previously treated in 12-week tetracycline-adapalene combination therapy studies. The main efficacy parameters included maintenance rate, which corresponds to the percentage of patients maintaining at least 50% improvement in lesion counts from previous induction therapy, and lesion counts.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast to the lack of statistical significance with respect to the grading used in the studies by Thiboutout et al [8] and Alirezei et al [7], the pooled effect of adapalene versus vehicle on the ‘number of patients maintaining at least 50% improvement achieved in the initial study' was statistically significant based on inflammatory (IL) and non-inflammatory lesion (NIL) count [7,8] (fig. 3).…”
Section: Resultsmentioning
confidence: 97%
“…The skin type/ethnic background, if stated, was: 100% Mongoloid [6], 87.5% Caucasian and 8.8% black [7], 75% white and 15.5% black [8], 45% white and 36% black [9]. Each of the included maintenance RCTs was a follow-up of an initial RCT on induction therapy.…”
Section: Resultsmentioning
confidence: 99%
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