Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: Results of a multicenter, randomized double-blind, controlled study

Thiboutot, Diane; Weiss, Jonathan S.; Bucko, A; Eichenfield, Lawrence F.; Jones, Terry M.; Clark, Scott D; Liu, Yin; Graeber, Michael; Kang, Sewon

doi:10.1016/j.jaad.2007.06.006

Cited by 149 publications

(171 citation statements)

References 27 publications

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“…Overall, the results of this study are limited due to being underpowered. However, they highlight trends that support previous literature (4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Discussionsupporting

confidence: 85%

Treatment failure of patients using topical acne treatments: an observational retrospective cohort study

Carstensen

Huang

Feldman

2013

Journal of Dermatological Treatment

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Background: While limited data from clinical trials show differences in efficacy between topical acne combination products and monotherapies, the impact in clinical practice is not explored. Purpose: To evaluate the effectiveness in clinical practice of prescribing topical acne combination treatments compared to monotherapy product(s) in minimizing treatment failures. Methods: Patients diagnosed with acne (ICD-9: 706.1) by a dermatologist between January 2009 and September 2011 and initially prescribed a topical acne treatment were identified. Multivariate Cox proportional hazards models were employed to compare the hazards of treatment failure for patients initially prescribed a combination product versus one monotherapy or multiple monotherapies. Subgroup analyses were also performed. Results: Three hundred and thirty-five patients were initially prescribed topical product(s) exclusively. The hazards of treatment failure for those prescribed a combination product compared to those prescribed one monotherapy product was HR = 0.91 (p = 0.65) and compared to those prescribed multiple monotherapy products was HR = 0.73 (p = 0.17). Limitations: Disease severity and treatments prescribed outside of the hospital system were not available. Conclusions: Treatment failures were consistent for patients prescribed combination product(s) or monotherapies.

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“…Overall, the results of this study are limited due to being underpowered. However, they highlight trends that support previous literature (4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Discussionsupporting

confidence: 85%

Treatment failure of patients using topical acne treatments: an observational retrospective cohort study

Carstensen

Huang

Feldman

2013

Journal of Dermatological Treatment

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“…Mean tolerability scores, based on erythema, scaling, dryness, and stinging / burning, peaked at the first week and declined thereafter. They concluded that fixed-dose combination of adapalene and BPO provides significantly greater safety for the treatment of acne vulgaris as early as week 1 relative to monotherapies, with a comparable safety profile to adapalene 15 . Earlier studies have shown that adapalene can be added to other therapies without significantly increasing skin irritation 12,15 .…”

Section: Discussionmentioning

confidence: 99%

Comparative side-effects of adapalene and benzoyl peroxide combination gel with Adapalene monotherapy and Benzoylperoxide monotherapy in the treatment of Acne vulgaris

et al. 2013

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A controlled clinical trial was conducted in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh to compare the side-effects of adapalene and benzoyl peroxide combination gel with adapalene monotherapy and benzoyl peroxide monotherapy in the treatment of acne vulgaris. The study conducted in sixty patients. Group A (case) 20 patients were treated with adapalene and benzoyl peroxide combination gel, group B (control) 20 patients were treated with topical adapalene and group C (control) 20 patients were treated with topical benzoyl peroxide. The side effects experienced by patients of different groups in their first follow up were noticed. In group A -erythema, scaling, dryness, burning and pruritus were present in 45%, 10%, 35%, 40% and 10% of patients and in group B, 35%, 25%, 30%, 35% and 15% respectively. However in group C dryness and pruritus were absent in all the patients and the erythema, scaling and burning were 30%, 25% and 25% respectively. In 5 th follow-up visit, in group A-erythema, scaling, dryness and pruritus were present in 15%, 5%, 15%, and 5% of patients respectively and burning was absent in group A. In group B erythema, scaling, dryness, and pruritus were 15%, 5%, 5% and 5% and burning was absent in group B. However in group C scaling, burning, dryness and pruritus were absent in all the patients. Erythema was present in 10% cases in 5 th follow-up visit. It was evidenced in the present study that the overall adverse effect is slightly higher with the adapalene-benzoyl peroxide combination therapy in relation to the adapalene and benzoyl peroxide (BPO) monotherapies in the treatment of acne vulgaris.

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“…67,68 The most common treatment-related adverse events reported in 12-week and 15-week clinical trials were burning/ stinging/tingling (29%), pruritus (11%), scaling/dry skin/xerosis (8%), and erythema/irritation (4%). 69 Another topical medication approved by the FDA and recommended by the AARS for the treatment of rosacea is sodium sulfacetamide 10%-sulfur 5%. 51 Sulfur has keratolytic, antifungal, and antibacterial activities.…”

Section: 49mentioning

confidence: 99%

Current Drug Therapies for Rosacea: A Chronic Vascular and Inflammatory Skin Disease

Feldman¹,

Huang²,

Huynh³

2014

JMCP

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Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: Results of a multicenter, randomized double-blind, controlled study

Cited by 149 publications

References 27 publications

Treatment failure of patients using topical acne treatments: an observational retrospective cohort study

Treatment failure of patients using topical acne treatments: an observational retrospective cohort study

Comparative side-effects of adapalene and benzoyl peroxide combination gel with Adapalene monotherapy and Benzoylperoxide monotherapy in the treatment of Acne vulgaris

Current Drug Therapies for Rosacea: A Chronic Vascular and Inflammatory Skin Disease

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