ADAMTS4 and Oxidative/Antioxidative Status in Preterm Premature Rupture of Membranes

Özler, Sibel; Öztaş, Efser; Guler, Basak Gumus; Ergin, Merve; Uygur, Dilek; Yücel, Aykan; Erel, Özcan; Danışman, Nuri

doi:10.1080/15513815.2016.1175529

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…Researchers found TOS to be higher in the maternal blood (Clerici et al, 2012; Ilhan et al, 2015; Soydinç et al, 2012, 2013) and vaginal washing fluid (Soydinc et al, 2013) in PTB compared to TB. TOS levels were significantly higher in amniotic tissue obtained at birth for women with pPROM compared to the term control group (Ozler et al, 2016). Findings collectively suggest that a local and systemic dysregulated redox environment may be associated with PTB.…”

Section: Resultsmentioning

confidence: 77%

“…Pressman et al (2011) found no differences in TAS in amniotic fluid between PTB and TB specimens. Ozler et al (2016), however, found that TAS trended lower in amniotic tissue obtained at birth for women with pPROM compared to the term control group. Together these inconclusive findings suggest that a dysregulated redox environment may be associated with PTB and is location specific.…”

mentioning

confidence: 76%

“…Proteomic approach using 2DE MALDI-TOF MS (Chang et al, 2013) Proteomic approach using MB-WCX and a time-jet tandem MALDI-mass spectrometer Ultraflex II (Gunko et al, (Cinkaya et al, 2010;Ozler et al, 2016;Pressman et al, 2011;Sandal et al, 2013;Soydinc et al, 2013;Soydinç et al, 2012) Spectrophotometry (Clerici et al, 2012;Ilhan et al, 2015;Minghetti et al, 2011) FRAP method (Lázár et al, 2015;Mustafa et al, 2010;Pathak et al, 2010) TOS Spectrophotometry (Clerici et al, 2012;Ilhan et al, 2015;Ozler et al, 2016;Sandal et al, 2013;Soydinc et al, 2013; damage from lipid peroxidation. The termination phase only occurs when two radicals conjugate and/or LOO reacts with a chain-breaking antioxidant (e.g., vitamin E; Ayala, Muñoz, & Argüelles, 2014;Chamulitrat & Mason, 1989).…”

Section: ) Peroxiredoxinsmentioning

confidence: 99%

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Oxidative Stress and Preterm Birth: An Integrative Review

Moore

Ahmad

Zimmerman

2018

Biological Research For Nursing

107

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Section: Resultsmentioning

confidence: 77%

mentioning

confidence: 76%

Section: ) Peroxiredoxinsmentioning

confidence: 99%

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Oxidative Stress and Preterm Birth: An Integrative Review

Moore

Ahmad

Zimmerman

2018

Biological Research For Nursing

107

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Oxidative stress biomarkers in pregnancy: a systematic review

Ibrahim,

Khoo,

Ismail

et al. 2024

Reprod Biol Endocrinol

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Background This systematic review explores the level of oxidative stress (OS) markers during pregnancy and their correlation with complications. Unlike previous studies, it refrains from directly investigating the role of OS but instead synthesises data on the levels of these markers and their implications for various pregnancy-related complications such as preeclampsia, intrauterine growth restrictions, preterm premature rupture of membranes, preterm labour, gestational diabetes mellitus and miscarriages. Method Study Design Utilizing a systematic review approach, we conducted a comprehensive search across databases, including MEDLINE, CINAHL (EBSCOhost), ScienceDirect, Web of Science, and SCOPUS. Our search encompassed all publication years in English. Results After evaluating 54,173 records, 45 studies with a low risk of bias were selected for inclusion. This systematic review has underscored the importance of these markers in both physiological and pathological pregnancy states such as preeclampsia, intrauterine growth restrictions, preterm premature rupture of membranes, preterm labour, gestational diabetes mellitus and miscarriages. Conclusion This systematic review provides valuable insights into the role of OS in pregnancy and their connection to complications. These selected studies delved deeply into OS markers during pregnancy and their implications for associated complications. The comprehensive findings highlighted the significance of OS markers in both normal and pathological pregnancy conditions, paving the way for further research in this field.

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Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-α and spontaneous preterm delivery in singleton pregnancies

Melekoğlu

Yılmaz

Çiftçi

et al. 2019

Journal of Perinatal Medicine

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Background We investigated the roles of inflammatory cytokines and the A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family in the etiopathogenesis of spontaneous preterm delivery by comparing the ADAMTS4, ADAMTS5, interleukin (IL)-6, and tumor necrosis factor-α (TNF-α) levels in second-trimester amniotic fluid between pregnant women with preterm birth and term controls. Methods All pregnant women who underwent second-trimester amniocentesis for genetic analysis between January 1, 2016, and January 1, 2018, were enrolled in this study. From this cohort, 22 patients who subsequently experienced spontaneous preterm delivery before 34 weeks of pregnancy formed the study group, and 22 age- and body mass index (BMI)-matched patients without preterm birth constituted the control group. Results No significant differences were observed between the preterm birth and control groups in terms of age, BMI, obstetric history of preterm delivery, gestational age at amniocentesis, or indication for amniocentesis. The mean amniotic fluid levels of ADAMTS4 and ADAMTS5 were significantly increased in the preterm birth group compared to the control group (248.3±22.6 and 182.4±19.8 pg/mL, P=0.012; and 198.6±21.6 and 159.1±21.7 pg/mL, P=0.035, respectively). Significantly increased IL-6 and TNF-α levels were also detected in the amniotic fluid of women who experienced spontaneous preterm delivery, relative to controls (142.1±16.2 and 95.8±16.4 pg/mL, P<0.001; and 139.4±12.5 and 89.6±11.2 pg/mL, P<0.001, respectively). Conclusion The results of this study imply that increased mid-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-α play an important role in the pathophysiology of spontaneous preterm delivery.

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ADAMTS4 and Oxidative/Antioxidative Status in Preterm Premature Rupture of Membranes

Cited by 3 publications

References 31 publications

Oxidative Stress and Preterm Birth: An Integrative Review

Oxidative Stress and Preterm Birth: An Integrative Review

Oxidative stress biomarkers in pregnancy: a systematic review

Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-α and spontaneous preterm delivery in singleton pregnancies

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