Adamts18 modulates the development of the aortic arch and common carotid artery

Ye, Shuai; Yang, Ning; Lu, Tong; Wu, Taojing; Wang, Liya; Pan, Yi-Hsuan; Cao, Xiaohua; Yuan, Xiao-bing; Wısnıewskı, Thomas; Dang, Song; Zhang, Wei

doi:10.1016/j.isci.2021.102672

Cited by 10 publications

(16 citation statements)

References 46 publications

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“…The hemodynamics of the AAAV could differ from that of a type-I aortic, arch as postulated in the paragraph above, according to adult studies [25]. We did not evaluate the velocities in the different segments of the fetal circulation as Clerici did in his study.…”

Section: Discussionmentioning

confidence: 96%

“…Recent studies suggest that multiple factors are involved in remodeling the aortic arch: growth factors, metalloproteinase and receptor signaling pathways. Among those, ADAMTS, a group of 19 secreted metalloproteinases, are involved in growth, branching, differentiation and valvular formation and play a decisive role in the development of the aortic arch and common carotid arteries [25]. Those factors are responsible not only for cardiovascular development but also for diseases such as atherosclerosis, pulmonary arterial hypertension and aneurysm.…”

Section: Discussionmentioning

confidence: 99%

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Prenatal Diagnosis of Bovine Aortic Arch Anatomic Variant

et al. 2022

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Fetal aortic arch development is an early and complex process that depends on many genetic and environmental factors. The final aortic arch varies greatly; it may take the form of a normal arch, anatomic variant (AAAV) with a common origin to that of the innominate artery and left common carotid artery (formerly known as “bovine aortic arch” (with an incidence of up to 27%)) or one of multiple pathological conditions. The present study aimed to establish the feasibility and impact of prenatal anatomic arch variants’ diagnosis. A retrospective study of 271 fetal second- and third-trimester anomaly scans was performed in our tertiary center. Examinations that evaluated the sagittal aortic arch were included and the branching pattern was assessed. Additionally, a literature data search based on the terms “common origin of innominate artery and left common carotid artery”, “bovine arch”, “bovine aortic” and “aortic arch anomalies” was performed. Results that referred to prenatal AAAV were retained and the papers evaluated. In our study, the AAA incidence was 1.93%, with 4 out of 5 cases being arch type B. All cases had minor associated conditions but a good postnatal outcome. An anatomic aortic variant with a common IA and LCCa prenatal diagnosis was found in a small number of studies; most of the cases described in pediatric and adult series were related to cardiac surgery for stenting, aneurysm or thoracic-associated diseases. The incidence of AAAV varied from 6 to 27% depending on the population studied (highest incidence in African individuals). The variant was highly associated with aortic dissection, pulmonary and cerebral embolism and increased risks of incidents during surgery. Diagnosing AAAV during a routine anatomic scan is feasible and diagnoses can be made when anomaly scans are performed. Awareness of the condition is important for postnatal surgery when other cardiac anomalies are found; this can prevent accidents with simple changes to the patient’s lifestyle, and, in the case of surgery, means we can adopt the correct surgical approach.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of Bovine Aortic Arch Anatomic Variant

et al. 2022

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“…The role of ADAMTS18 in vascular development was researched by using an Adamts18 knockout mouse model [ 88 ]. During the development of the mice, Adamts18 mRNA was observed in cells surrounding the ascending aorta and carotid artery.…”

Section: Adamts18 Involved In Aorta Developmentmentioning

confidence: 99%

“…These phenomena would, thus, activate the Notch3 signaling pathway. This activation ends up affecting the differentiation of cranial neural crest cells into VSMC [ 88 ]. The repertoire of ADAMTS18 substrates needs to be further investigated to better understand the role of this enzyme in the aortic arch and carotid artery.…”

Section: Adamts18 Involved In Aorta Developmentmentioning

confidence: 99%

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ADAMTS Proteins and Vascular Remodeling in Aortic Aneurysms

et al. 2021

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Extracellular matrix (ECM) in the vascular wall is a highly dynamic structure composed of a set of different molecules such as elastins, collagens, fibronectin (Fn), laminins, proteoglycans, and polysaccharides. ECM undergoes remodeling processes to regulate vascular smooth muscle and endothelial cells’ proliferation, differentiation, and adhesion. Abnormalities affecting the ECM can lead to alteration in cellular behavior and from this, this can conduce to the development of pathologies. Metalloproteases play a key role in maintaining the homeostasis of ECM by mediating the cleavage of different ECM components. There are different types of metalloproteases: matrix metalloproteinases (MMPs), disintegrin and metalloproteinases (ADAMs), and ADAMs with thrombospondin motifs (ADAMTSs). ADAMTSs have been found to participate in cardiovascular physiology and diseases and specifically in aortic aneurysms. This review aims to decipher the potential role of ADAMTS proteins in the physiopathologic development of Thoracic Aortic Aneurysms (TAA) and Abdominal Aortic Aneurysms (AAA). This review will focus on what is known on the ADAMTS family involved in human aneurysms from human tissues to mouse models. The recent findings on THSD4 (encoding ADAMTSL6) mutations in TAA give a new insight on the involvement of the ADAMTS family in TAA.

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Early development of the breathing network

Isik

Hernández-Miranda²

2022

Respiratory Neurobiology - Physiology and Clinical Disorders, Part I

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Adamts18 modulates the development of the aortic arch and common carotid artery

Cited by 10 publications

References 46 publications

Prenatal Diagnosis of Bovine Aortic Arch Anatomic Variant

Prenatal Diagnosis of Bovine Aortic Arch Anatomic Variant

ADAMTS Proteins and Vascular Remodeling in Aortic Aneurysms

Early development of the breathing network

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