ADAMs family in kidney physiology and pathology

Zhu, Huanhuan; Nie, Wanyun; Armando, Inés; Han, Fei

doi:10.1016/j.ebiom.2021.103628

Cited by 5 publications

(2 citation statements)

References 83 publications

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“…The primary keywords included within cluster 0 were associated with the etiology, diagnosis, and blood/urinary biomarkers of DN. The etiological basis for DN has been an area of extensive research interest in recent years, revealing this condition to be associated with inflammatory response, glomerulosclerosis, renal tubular fibrosis, podocyte damage and loss, oxidative stress, autophagy, and apoptotic cell death [ 14 – 17 ]. There is also evidence that mitochondrial dysfunction and endoplasmic reticulum stress can contribute to the development of this condition [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Bibliometric Study of Trends in the Diabetic Nephropathy Research Space from 2016 to 2020

Shao

2022

Oxidative Medicine and Cellular Longevity

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Background. Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus (DM), but no bibliometric studies pertaining to DN have been published within the last 5 years. Objectives. Most prior studies have focused on specific problems in the DN field. This study attempts to sort out and visualize the knowledge framework in this research space from a holistic and highly generalized perspective. Readers can quickly understand and master the knowledge regarding DN research conducted from 2016 to 2020, in addition to predicting future research hotspots and possible directions for development in this field in a comprehensive and scientifically valid manner. Methods. Literature information, discourse matrices, and co-occurrence matrices were generated using BICOMB. gCLUTO was used for biclustering analyses and visualization. Strategic diagrams were generated using GraphPad Prism 5. The social network analysis (SNA) was analyzed and plotted using Ucinet 6.0 and Netdraw. Results. In total, 55 high-frequency MeSH terms/MeSH subheadings were selected and grouped into 5 clusters in a biclustering analysis. These analyses revealed that extensive studies of the etiology, diagnosis, and treatment of DN have been conducted over the last 5 years, while further research regarding DN-related single nucleotide polymorphisms, miRNAs, and signal transduction are warranted as these research areas remain relatively immature. Conclusion. Together, these results outline a robust knowledge structure pertaining to the field of DN-related research over the last 5 years, providing a valuable resource for readers by enabling the easy comprehension of relevant information. In addition, this analysis highlights predicted DN-related research directions and hotspots.

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Section: Discussionmentioning

confidence: 99%

Bibliometric Study of Trends in the Diabetic Nephropathy Research Space from 2016 to 2020

Shao

2022

Oxidative Medicine and Cellular Longevity

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“…There are nearly half of the approximately 34 ADAM family members identified so far in mice and 22 in humans (Zhu et al, 2021) (Table 1) that are specifically or predominantly expressed in a tissue-specific manner, such as in testis or epididymis, suggesting an integral involvement of these ADAMs in reproduction and fertilization in mammals (Weber and Saftig, 2012). However, other ADAMs are expressed in a ubiquitous manner, as they can be found in a broad range of cells and tissues and are implicated in several biological processes, among them development, inflammation, and cancer (Mullooly et al, 2016).…”

Section: Adam Family Members and Adam8mentioning

confidence: 99%

The versatile roles of ADAM8 in cancer cell migration, mechanics, and extracellular matrix remodeling

Mierke

2023

Front. Cell Dev. Biol.

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The posttranslational proteolytic cleavage is a unique and irreversible process that governs the function and half-life of numerous proteins. Thereby the role of the family of A disintegrin and metalloproteases (ADAMs) plays a leading part. A member of this family, ADAM8, has gained attention in regulating disorders, such as neurogenerative diseases, immune function and cancer, by attenuating the function of proteins nearby the extracellular membrane leaflet. This process of “ectodomain shedding” can alter the turnover rate of a number of transmembrane proteins that function in cell adhesion and receptor signal transduction. In the past, the major focus of research about ADAMs have been on neurogenerative diseases, such as Alzheimer, however, there seems to be evidence for a connection between ADAM8 and cancer. The role of ADAMs in the field of cancer research has gained recent attention, but it has been not yet been extensively addressed. Thus, this review article highlights the various roles of ADAM8 with particular emphasis on pathological conditions, such as cancer and malignant cancer progression. Here, the shedding function, direct and indirect matrix degradation, effects on cancer cell mobility and transmigration, and the interplay of ADAM8 with matrix-embedded neighboring cells are presented and discussed. Moreover, the most probable mechanical impact of ADAM8 on cancer cells and their matrix environment is addressed and debated. In summary, this review presents recent advances in substrates/ligands and functions of ADAM8 in its new role in cancer and its potential link to cell mechanical properties and discusses matrix mechanics modifying properties. A deeper comprehension of the regulatory mechanisms governing the expression, subcellular localization, and activity of ADAM8 is expected to reveal appropriate drug targets that will permit a more tailored and fine-tuned modification of its proteolytic activity in cancer development and metastasis.

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Sirt1 activation prevents high glucose-induced angiotensin converting enzyme 2 downregulation in renal tubular cells by regulating the TIMP3/ADAM17 pathway

Guo,

Niu,

et al. 2024

Mol Biol Rep

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ADAMs family in kidney physiology and pathology

Cited by 5 publications

References 83 publications

Bibliometric Study of Trends in the Diabetic Nephropathy Research Space from 2016 to 2020

Bibliometric Study of Trends in the Diabetic Nephropathy Research Space from 2016 to 2020

The versatile roles of ADAM8 in cancer cell migration, mechanics, and extracellular matrix remodeling

Sirt1 activation prevents high glucose-induced angiotensin converting enzyme 2 downregulation in renal tubular cells by regulating the TIMP3/ADAM17 pathway

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