Adamantinoma of the tibia: a clinicoradiologic study of four cases

Bouaziz, Mouna Chelli; Meherzi, M.H.; Jlassi, Helmi; Nouri, H.; Chaabane, Skander; Daghfous, Mohamed Samir; Karray, S.; Ladeb, Mohamed Fethi

doi:10.1007/s00590-009-0448-4

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…However, location in the diaphysis, extension towards the bone marrow, single or multiple nodular lesions in one or more foci, and intense and homogeneous enhancement are familiar signs of adamantinoma, while dysplasias are characterized by cortical involvement without canal extension (16). Computed tomography (Figure 2) more accurately shows the osteolytic formation, the involvement of the cortex and tumor extension to the nearby soft tissues, while if can also reveal pulmonary metastases, without detecting intraosseous tumor extension (38). Magnetic resonance imaging (MRI), as it is specialized for revealing lesions of soft tissues, seems to be the most appropriate examination for the differential diagnosis between adamantinoma and other skeletal tumors, such as fibrous or osteofibrous dysplasia, osteosarcoma, Ewing's sarcoma and metastatic carcinoma (39,40).…”

Section: Radiological Featuresmentioning

confidence: 99%

Adamantinoma: An Updated Review

Varvarousis

Skandalakis

Barbouti

et al. 2021

In Vivo

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Adamantinoma is a biphasic tumor, with a low potential for malignancy, characterized by clusters of epithelial cells surrounded by a relatively bland spindle-cell osteofibrous component. The aim of the present study was to review the updated data regarding epidemiology; pathogenesis; clinical presentation; radiological, histopathological and ultrastructural findings; and treatment options of adamantinoma. In X-ray, it is usually seen as an eccentric and sometimes central, lobular, lytic lesion with sclerotic margins of overlapping radiolucency, and a characteristic 'soap-bubble' appearance. Magnetic resonance imaging seems to be the most appropriate examination for differential diagnosis between adamantinoma and other skeletal tumors. Histologically, adamantinoma is identified as classic adamantinoma or osteofibrous-like adamantinoma. Classic adamantinoma is classified into four patterns of growth: Basaloid, tubular, spindle cell, and squamous. The preferable treatment of this tumor type is en bloc resection within wide operative margins, which may include suspicious regional lymph nodes, with limb reconstruction and limb salvage.According to the definition of the World Health Organization, adamantinoma is a miscellaneous malignant biphasic tumor and its characteristics are clusters of epithelial cells surrounded by a relatively bland spindle-cell osteofibrous component (1, 2). It is a tumor with low frequency (as it occurs in less than 0.5% of all primary skeletal tumors), in terms of age most often developing between the age of 20 and 50 years, and it is more common in men. It may be located in several bones; however, the mid shaft of the tibia, with or without fibula involvement, is its most common location (3-5). The main symptom reported by patients is pain (6). Treatment of adamantinoma includes extensive resection and reconstruction of bone defect with the use of autograft, allograft, bone transport, and endoprosthesis (7).In our previous article, we presented the epidemiological, clinical, radiological and pathological features as well as treatment options of adamantinoma (4). The aim of the present study was to review the updated data regarding history, incidence, epidemiology, origin and pathogenesis, clinical features, as well as radiological, histopathological and ultrastructural findings, new treatment strategies and prognosis of adamantinoma. The History of AdamantinomaAlthough adamantinoma is an unusual bone tumor, its origin has been debated for almost a century. The term adamantinoma comes from the ancient Greek word adamantinos, which means very hard, as the root word adamas means diamond. The first reported case of a primary skeletal tumor with epithelial characteristics, observed in the ulna, was by Maier (8) in 1900, while in 1913, a physician from Germany, called this tumor 'adamantinoma' as he observed that during embryonic development adamantine 3045 This article is freely accessible online.

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Section: Radiological Featuresmentioning

confidence: 99%

Adamantinoma: An Updated Review

Varvarousis

Skandalakis

Barbouti

et al. 2021

In Vivo

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Adamantinoma filling the medullary space of the tibia: A case report

Chen

Zhang

2019

Radiology Case Reports

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Adamantinoma of the bone is a rare low-grade bony tumor that accounts for less than 1% of all primary bone tumors. On imaging, adamantinoma may be similar to other tumors such as osteofibrous dysplasia, for which the treatment protocol is completely different. Therefore, correct diagnosis and staging of adamantinoma ensures that the patient will undergo appropriate surgery. We present a case of atypical adamantinoma to highlight the fact that adamantinoma should be considered in the differential diagnosis of tibial tumors.

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Adamantinoma of the tibia: a clinicoradiologic study of four cases

Cited by 2 publications

References 10 publications

Adamantinoma: An Updated Review

Adamantinoma: An Updated Review

Adamantinoma filling the medullary space of the tibia: A case report

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